Class I major histocompatibility complex genes in vertebrate species: What is the common denominator?

1987 ◽  
Vol 6 (1-2) ◽  
pp. 57-66 ◽  
Author(s):  
Thomas J. Kindt ◽  
Dinah S. Singer
Keyword(s):  
Major Histocompatibility Complex ◽  
Class I ◽  
Common Denominator ◽  
Vertebrate Species ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
The Common

scholarly journals Different Evolutionary Histories in Two Subgenomic Regions of the Major Histocompatibility Complex

1999 ◽  
Vol 9 (6) ◽  
pp. 541-549 ◽  
Author(s):  
Silvana Gaudieri ◽  
Jerzy K. Kulski ◽  
Roger L. Dawkins ◽  
Takashi Gojobori
Keyword(s):  
Major Histocompatibility Complex ◽  
Homologous Recombination ◽  
Hla Class I ◽  
Gene Families ◽  
Class I ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Multicopy Gene ◽  
History Of ◽  
The Common

Two subgenomic regions within the major histocompatibility complex, the alpha and beta blocks, contain members of the multicopy gene families HLA class I, human endogenous retroviral sequence (HERV-16; previously known as P5 and PERB3), hemochromatosis candidate genes (HCG) (II, IV, VIII, IX), 3.8-1, and MIC (PERB11). In this study we show that the two blocks consist of imperfect duplicated segments, which contain linked members of the different gene families. The duplication and truncation sites of the segments are associated with retroelements. The retroelement sites appear to generate the imperfect duplications, insertions/deletions, and rearrangements, most likely via homologous recombination. Although the two blocks share several characteristics, they differ in the number and orientation of the duplicated segments. On the 62.1 haplotype, the alpha block consists of at least 10 duplicated segments that predominantly contain pseudogenes and gene fragments of the HLA class I and MIC (PERB11) gene families. In contrast, the beta block has two major duplications containing the genes HLA-B and HLA-C, and MICA(PERB11.1) and MICB(PERB11.2). Given the common origin between the blocks, we reconstructed the duplication history of the segments to understand the processes involved in producing the different organization in the two blocks. We then found that the beta block contains four distinct duplications from two separate events, whereas the alpha block is characterized by multisegment duplications. We will discuss these results in relation to the genetic content of the two blocks.

scholarly journals Expression of the Major Histocompatibility Complex Class I Molecule Mamu-A*01 Is Associated with Control of Simian Immunodeficiency Virus SIVmac239 Replication

2003 ◽  
Vol 77 (4) ◽  
pp. 2736-2740 ◽  
Author(s):  
Bianca R. Mothé ◽  
Jason Weinfurter ◽  
Chenxi Wang ◽  
William Rehrauer ◽  
Nancy Wilson ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Simian Immunodeficiency Virus ◽  
Mhc Class I ◽  
Virus Disease ◽  
Class I ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Immunodeficiency Virus ◽  
The Common ◽  
The Relationship

ABSTRACT Several HLA alleles are associated with attenuated human immunodeficiency virus disease progression. We explored the relationship between the expression of particular major histocompatibility complex (MHC) class I alleles and viremia in simian immunodeficiency virus SIVmac239-infected macaques. Of the common MHC class I alleles, animals that expressed Mamu-A*01 exhibited the best control of viral replication.

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