Effect of dietary copper and zinc levels on tissue copper, zinc, and iron in male rats

1985 ◽  
Vol 8 (2) ◽  
pp. 123-136 ◽  
Author(s):  
Carl L. Keen ◽  
Nancy H. Reinstein ◽  
Jo Goudey-Lefevre ◽  
Michael Lefevre ◽  
Bo Lönnerdal ◽  
...  
Keyword(s):  
Male Rats ◽  
Dietary Copper ◽  
Copper And Zinc ◽  
Copper Zinc ◽  
Zinc Levels

Serum copper and zinc levels and copper/zinc ratio in patients with breast cancer

1994 ◽  
Vol 40 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Idris Yücel ◽  
Fikret Arpaci ◽  
Ahmet Özet ◽  
Bülent Döner ◽  
Turan Karayilanoĝlu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Serum Copper ◽  
Copper And Zinc ◽  
Copper Zinc ◽  
Zinc Levels

scholarly journals Serum Copper and Zinc Levels and Risk of Hepatocellular Carcinoma: A 1:1 Matched Case-Control Study

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1397-1397
Author(s):  
Aiping Fang ◽  
Huilian Zhu
Keyword(s):  
Serum Zinc ◽  
Serum Levels ◽  
Case Control ◽  
Serum Copper ◽  
Copper And Zinc ◽  
Copper Zinc ◽  
Matched Case ◽  
Zinc Levels ◽  
Control Study ◽  
Serum Zinc Levels

Abstract Objectives Copper and zinc have been involved in the development of liver cancer in laboratory models, yet data from epidemiological studies are limited. We investigated the association of serum levels of copper and zinc and their ratio with the risk of hepatocellular carcinoma (HCC) in a Chinese population. Methods This is a 1:1 matched case-control study conducted between September 2013 and February 2017. Each case with newly diagnosed HCC from the Guangdong Liver Cancer Cohort (GLCC) was matched to one healthy control from the Guangzhou Nutrition and Health Study by age (±1 years) and sex. Serum copper and zinc levels were quantified using inductively coupled plasma mass spectrometry. Conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for age, sex, body mass index, hepatitis infection, smoking status, alcohol drinking status, diabetes, and chronic inflammation. Serum levels of copper and zinc and their ratio were included in models in tertiles with cutpoints based on the distribution of the control participants. Results A total of 556 case-control pairs were included in this study. Mean (SD) age was 60.3 (7.1) years and 83.8% of the participants were men. HCC cases had significantly higher copper and lower zinc levels, and thus higher copper/zinc, than controls. Higher serum zinc levels were associated with a lower risk of HCC (ORT3 vs T1 = 0.21; 95% CI: 0.07–0.64, P for trend = 0.005). However, there was no association between serum copper levels and HCC risk (ORT3 vs T1 = 1.53; 95% CI: 0.62–3.76, P for trend = 0.375). Higher copper/zinc ratio was associated with increased risk of HCC (ORT3 vs T1 = 3.06; 95% CI: 1.08–8.70, P for trend = 0.049). Conclusions Serum zinc levels were inversely associated with the risk of HCC, suggesting a protective role of zinc in preventing HCC development. Funding Sources This work was supported by the National Natural Science Foundation of China.

scholarly journals Association of Dietary Copper and Zinc Levels with Hepatic Copper and Zinc Concentration in Labrador Retrievers

2012 ◽  
Vol 26 (6) ◽  
pp. 1274-1280 ◽  
Author(s):  
H. Fieten ◽  
B.D. Hooijer-Nouwens ◽  
V.C. Biourge ◽  
P.A.J. Leegwater ◽  
A.L. Watson ◽  
...  
Keyword(s):  
Zinc Concentration ◽  
Dietary Copper ◽  
Hepatic Copper ◽  
Copper And Zinc ◽  
Zinc Levels ◽  
Labrador Retrievers

Bioavailability of dietary copper and zinc proteinates and sulphates in adult Texel sheep

2000 ◽  
Vol 2000 ◽  
pp. 84-84
Author(s):  
J.P. Ryan ◽  
P. Kearns ◽  
T. Quinn
Keyword(s):  
Zinc Sulphate ◽  
Inorganic Salts ◽  
Dietary Copper ◽  
Zinc Availability ◽  
Copper And Zinc ◽  
World Regions ◽  
Plasma Copper ◽  
Zinc Levels ◽  
Almost All

Mineral deficiencies for livestock are reported from almost all world regions. Deficiency can be caused by inadequate intake or by the presence of antagonists in the diet. Traditionally, inorganic salts, such as oxides and sulphates have been added to the diet to meet the requirements of the animal. More recently, there has been increasing interest in mineral chelates. Studies by Rojas et al. (1995) and Ward et al. (1996) have reported that the copper and zinc availability in copper and zinc chelates is greater than in the traditional inorganic salts. Other studies by Kegley et al. (1994) and Schell et al. (1996) reported contradictory results. In this study, two separate trials were carried out to compare the effects of Bioplex copper and Bioplex zinc with the effects of copper and zinc sulphate on plasma copper and zinc levels in adult Texel sheep.

Analyses of Serum Copper and Zinc Levels and Copper/Zinc Ratios in Skin Diseases

1993 ◽  
Vol 20 (1) ◽  
pp. 21-24 ◽  
Author(s):  
Michiko Tasaki ◽  
Katsumi Hanada ◽  
Isao Hashimoto
Keyword(s):  
Skin Diseases ◽  
Serum Copper ◽  
Copper And Zinc ◽  
Copper Zinc ◽  
Zinc Levels

scholarly journals Relationships between copper, zinc and iron in the plasma, soft tissues and skeleton of the rat during Cu deficiency

1973 ◽  
Vol 29 (1) ◽  
pp. 73-85 ◽  
Author(s):  
Begona Alfaro ◽  
F. W. Heaton
Keyword(s):  
Bone Marrow ◽  
Stainless Steel ◽  
Copper Deficiency ◽  
Soft Tissues ◽  
Male Rats ◽  
Dietary Copper ◽  
Cu Deficiency ◽  
Depletion Period ◽  
Copper Zinc ◽  
Hypertrophy Of The Heart

1. The effect of dietary copper deficiency on the distribution of Cu, zinc and iron between plasma, various soft tissues and bone was investigated in weanling male rats.2. The concentration of Cu decreased in plasma, liver, kidney and femur, and the concentration in plasma correlated with that in all three organs. The total amount of Cu in the liver was reduced over the whole depletion period and a net loss from kidney also occurred over a shorter period, indicating that liver and, to a lesser extent, kidney both provide a mobilizable reserve of Cu.3. Animals in galvanized cages developed Cu deficiency more rapidly than similar rats in stainless-steel cages owing to Zn aggravating the depletion. Zn accumulated in the liver and femur of Cu deficient rats, particularly when they were housed in galvanized cages.4. Cu-deficient animals accumulated Fe in the liver, but had reduced concentrations in plasma, kidney and spleen. The hypertrophy of the heart and bone-marrow observed in Cu-deficient rats appeared to be secondary to the anaemia resulting from this impaired mobilization of hepatic Fe.

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