Biological half time of deposited nickel oxide aerosol in rat lung by inhalation

1985 ◽  
Vol 8 (3) ◽  
pp. 203-210 ◽  
Author(s):  
Isamu Tanaka ◽  
Shigeko Ishimatsu ◽  
Koji Matsuno ◽  
Yasushi Kodama ◽  
Kenzaburo Tsuchiya
Keyword(s):  
Nickel Oxide ◽  
Half Time ◽  
Rat Lung ◽  
Biological Half Time

Pattern of Uptake of Americium-241 by the Rat Skeleton and its Subsequent Redistribution and Retention: Implications for Human Dosimetry and Toxicology

1983 ◽  
Vol 2 (1) ◽  
pp. 101-120 ◽  
Author(s):  
N.D. Priest ◽  
G. Howells ◽  
D. Green ◽  
J.W. Haines
Keyword(s):  
Bone Marrow ◽  
Bone Resorption ◽  
Cortical Bone ◽  
Female Rat ◽  
Half Time ◽  
Bone Surface ◽  
Similar Model ◽  
Phagocytic Cells ◽  
Biological Half Time

The distribution and retention of intravenously injected 241Am in the skeleton of the female rat has been investigated using autoradiographic and radiochemical techniques. The studies were designed to assess the dosimetric and toxicologic implications of an 241Am intake by man. They showed that in the rat approximately one third of the intravenously injected 241Am was deposited in the skeleton where it appeared to be retained with a long biological half-time. The studies also showed: 1241Am is initially deposited onto all types of bone surface including endosteal surfaces, periosteal surfaces and those of the vascular canals within cortical bone, but seems to be preferentially deposited onto those that are resorbing, 2 Bone accretion results in the burial of surface deposits of 241Am, 3 Bone resorption causes the removal of 241 Am from surfaces, 4 Resorbed 241Am is retained by phagocytic cells (probably macrophages) in the bone marrow, 5 The transfer of 241Am from the phagocytic cells in the marrow to adjacent bone surfaces seems to occur, (local recycling). 6 The possibility that some of the 241Am removed from the bone surfaces enters the blood and is redeposited in bone, (systemic recycling) cannot be dismissed These results show that 241Am deposition and redistribution in bone shares many characteristics with other 'bone surface-seeking radionuclides' typified by 239Pu. Consequently, it is suggested that a similar model to that used to calculate annual limits of intake for 239Pu in man would be suitable for the calculation of corresponding values for the 241Am isotopes.

scholarly journals Investigation of Gene Expression of MMP-2 and TIMP-2 mRNA in Rat Lung in Inhaled Nickel Oxide and Titanium Dioxide Nanoparticles

2011 ◽  
Vol 49 (3) ◽  
pp. 344-352 ◽  
Author(s):  
Yasuo MORIMOTO ◽  
Takako OYABU ◽  
Akira OGAMI ◽  
Toshihiko MYOJO ◽  
Etsushi KURODA ◽  
...  
Keyword(s):  
Gene Expression ◽  
Titanium Dioxide ◽  
Nickel Oxide ◽  
Titanium Dioxide Nanoparticles ◽  
Rat Lung

Alveolar clearance in dogs after inhalation of an iron 59 oxide aerosol

1962 ◽  
Vol 17 (3) ◽  
pp. 429-432 ◽  
Author(s):  
F. R. Gibb ◽  
P. E. Morrow
Keyword(s):  
Standard Deviation ◽  
Respiratory Tract ◽  
Clearance Rate ◽  
Geometric Standard Deviation ◽  
Probe Type ◽  
Half Time ◽  
Average Value ◽  
Biological Half Time ◽  
Median Diameter ◽  
Count Median Diameter

Six dogs each received two 60-min exposures, 6 months apart, to an aerosol of iron 59 oxide, having an average count median diameter of 0.09 μ and a geometric standard deviation of 1.8. The concentration of iron 59 in the inspired air ranged between 0.004–0.017 μc/liter. Lung measurements were made immediately after each exposure and up to 30 days postexposure. This procedure was followed in both initial and repeat exposures of each dog. A probe-type scintillation detector fitted with a focusing collimator was used to limit the measurements to specific respiratory tract positions on each dog. The biological half-time for alveolar clearance in the 12 studies ranged from 44 to 82 days with an average value of 62 days (sd 8.8 days). This consistency suggests the probability of a normal clearance rate and the possibility of its use as a functional test. Submitted on July 11, 1961

scholarly journals On the biological half-time of hexavalent chromium in rats.

1983 ◽  
Vol 21 (1) ◽  
pp. 25-34 ◽  
Author(s):  
Seiva YAMAGUCHI ◽  
Kenichi SANO ◽  
Nobuhiro SHIMOJO
Keyword(s):  
Hexavalent Chromium ◽  
Half Time ◽  
Biological Half Time

The Biological Half-time of Radioactive Cs in Poikilothermic and Homeothermic Animals

1989 ◽  
Vol 56 (4) ◽  
pp. 473-484 ◽  
Author(s):  
H. Mailhot ◽  
R. H. Peters ◽  
R. J. Cornett
Keyword(s):  
Half Time ◽  
Biological Half Time

Biopersistence of Inhaled Nickel Oxide Nanoparticles in Rat Lung

2007 ◽  
Vol 19 (sup1) ◽  
pp. 55-58 ◽  
Author(s):  
T. Oyabu ◽  
A. Ogami ◽  
Y. Morimoto ◽  
M. Shimada ◽  
W. Lenggoro ◽  
...  
Keyword(s):  
Nickel Oxide ◽  
Oxide Nanoparticles ◽  
Rat Lung ◽  
Nickel Oxide Nanoparticles
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