Interaction of trace elements in a longitudinal study of human milk from full-term and preterm mothers

1994 ◽  
Vol 41 (3) ◽  
pp. 321-330 ◽  
Author(s):  
Laura Perrone ◽  
Liliana Di Palma ◽  
Rosario Di Toro ◽  
Giancarlo Gialanella ◽  
Renata Moro
Keyword(s):  
Trace Elements ◽  
Longitudinal Study ◽  
Human Milk ◽  
Full Term

scholarly journals Levels of Cytokines (IL-1β, IL-2, IL-6, IL-8, TNF-α) and Trace Elements (Zn, Cu) in Breast Milk From Mothers of Preterm and Term Infants

2005 ◽  
Vol 2005 (6) ◽  
pp. 331-336 ◽  
Author(s):  
Bilal Ustundag ◽  
Erdal Yilmaz ◽  
Yasar Dogan ◽  
Saadet Akarsu ◽  
Halit Canatan ◽  
...  
Keyword(s):  
Trace Elements ◽  
Immune System ◽  
Human Milk ◽  
Premature Infants ◽  
Full Term ◽  
Mature Milk ◽  
Term Infants ◽  
Necrosis Factor Alpha ◽  
Significant Difference ◽  
Cytokine Levels

It has been well documented that human milk contains several immunomodulator components which are important during infant period when the newborn's immune system is still under development. In this study, we aim at examining levels of cytokines, zinc (Zn), and copper (Cu) in milk from mothers of premature and mature infants, and comparing changes during lactation periods consequently. Milk was collected from total of 40 mothers (group M: mothers of mature infants,n=20; group PM: mothers of premature infants,n=20) from four lactation stages: colostrum (0–7 days), transitional (7–14 days), mature milk (21 days), and mature milk (2nd month). Levels of cytokines (interleukin [IL]-lβ, IL-2, IL-6, IL-8, tumor necrosis factor-alpha [TNF-α]) were determined by chemiluminesence method, whereas atomic absorption spectrophotometer was used for the determination of Zn and Cu levels. Cytokine levels were determined to be high in colostrum and transient milk from mothers of full-term infants, whereas their levels were reduced drastically in the 21st day and the 2nd month milk (P<.01,P<.001). Similar trends were observed in milk from mothers of premature infants, but cytokine levels were significantly lower in colostrum compared to colostrum from mothers of mature infants (P<.01). The differences in cytokine levels were continuous in transient milk (P<.05) and mature milk (21 days) (P<.05), whereas there was no statistically significant differences between milk from both groups of mothers in the 2nd month (P>.05). Zn levels in milk from mothers of premature infants were significantly lower compared to the ones from mothers of mature infants (P<.01) and these differences continued through the 2nd month. Although Cu levels were lower in milk from mothers of premature infants, there was no statistically significant difference except colostrum (P>.05). Our results clearly demonstrate that the level of immunomodulating agents such as cytokines and trace elements in milk from mothers of premature infants is less than the level of the same agents in milk from mothers of full-term infants. Although there are commercially available products for infant feeding, human milk is still the best natural nutrient for newborns. Therefore, when premature infants are breastfed, necessary precautions such as supplemantary diets must be considered for possible infections and risks related with immune system deficiency.

scholarly journals Human Milk Concentrations of Minerals, Essential and Toxic Trace Elements and Association with Selective Medical, Social, Demographic and Environmental Factors

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1885
Author(s):  
Natalia Mandiá ◽  
Pilar Bermejo-Barrera ◽  
Paloma Herbello ◽  
Olalla López-Suárez ◽  
Jose M. Fraga ◽  
...  
Keyword(s):  
Trace Elements ◽  
Human Milk ◽  
Case Series ◽  
Full Term ◽  
Nutritional Deficiencies ◽  
Cross Sectional ◽  
Toxic Trace Elements ◽  
Case Series Study ◽  
Increased Risk ◽  
First Time

This study aims to quantify concentrations of minerals and trace elements in human milk (HM) and infant formula (IF) and evaluate associations with medical, social, environmental, and demographic variables. A prospective, case series study of 170 nursing mothers was made. HM samples were obtained from full-term (colostrum, intermediate and mature HM) and preterm (mature HM) mothers. Variables of interest were assessed by a questionnaire. For comparison, IF samples (n = 30) were analyzed in a cross-sectional study. Concentrations of 35 minerals, essential and toxic trace elements were quantified, 5 for the first time: thallium in HM and IF; strontium in preterm HM; and gallium, lithium and uranium in IF. In preterm and full-term HM, levels of selenium (p < 0.001) were significantly lower than recommended and were associated with low birth weight (p < 0.002). Cesium and strontium concentrations were significantly higher than recommended (p < 0.001). Associations were observed between arsenic and residence in an urban area (p = 0.013), and between lead and smoking (p = 0.024) and well-water consumption (p = 0.046). In IF, aluminum, vanadium, and uranium levels were higher than in HM (p < 0.001); uranium, quantified for the first time, was 100 times higher in all types of IF than in HM. Our results indicate that concentrations of most trace elements were within internationally accepted ranges for HM and IF. However, preterm infants are at increased risk of nutritional deficiencies and toxicity. IF manufacturers should reduce the content of toxic trace elements.

Medium- and long-chain triacylglycerols composition in preterm and full-term human milk across different lactation stages

LWT ◽  
2021 ◽  
Vol 142 ◽  
pp. 110907
Author(s):  
Tinglan Yuan ◽  
Wei Wei ◽  
Xinghe Zhang ◽  
Lei Wang ◽  
Xinyue Dai ◽  
...  
Keyword(s):  
Human Milk ◽  
Full Term ◽  
Long Chain

Interleukin-10 and -12 in human milk at 3 stages of lactation: A longitudinal study

2007 ◽  
Vol 24 (3) ◽  
pp. 603-610 ◽  
Author(s):  
H. Levent Yilmaz ◽  
Esra Selver Saygili-Yilmaz ◽  
Ramazan Gunesacar
Keyword(s):  
Longitudinal Study ◽  
Human Milk ◽  
Interleukin 10

WEIGHT GAINS IN THE FIRST FOUR WEEKS OF INFANCY: A COMPARISON OF THREE DIETS

PEDIATRICS ◽  
1956 ◽  
Vol 18 (3) ◽  
pp. 362-368
Author(s):  
Ruth T. Gross ◽  
Lincoln E. Moses
Keyword(s):  
Human Milk ◽  
Statistical Methods ◽  
Full Term ◽  
Clinical Judgement ◽  
Careful Selection ◽  
Term Infants ◽  
Weight Gains ◽  
The Many ◽  
Selection Of

Four hundred seven healthy, full-term infants were divided into three groups and fed, respectively, a formula of evaporated milk and water with 5% carbohydrate; human milk; and a special modified evaporated milk designed to simulate human milk. No other foods were added to the diet. A comparison of the three groups was made, based on weight gains from birth to the end of the first 4 weeks. The conclusions refer only to weight gains; no attempt was made to determine the superiority of any particular diet. The data show no significant differences in the 4-week weight gains among the three groups of infants, although sensitive statistical methods could be validly applied to the problem. These methods are explained. The authors wish to emphasize the many variables which must be taken into account in a study of this sort; the necessity for careful selection of valid statistical methods; the importance of critical clinical judgement in the evaluation of the results.

Trace Element Deficiency and Cot Deaths

1981 ◽  
Vol 21 (1) ◽  
pp. 41-46 ◽  
Author(s):  
R. M. Raie ◽  
H. Smith
Keyword(s):  
Trace Elements ◽  
Human Milk ◽  
Trace Element ◽  
Normal Adult ◽  
Toxic Trace Elements ◽  
Essential Trace Elements ◽  
Trace Element Deficiency

The level of 10 trace elements (As, Br, Co, Cu, Fe, Hg, Mg, Mn, Se, Zn) in infant tissues (5 cot deaths, 4 other causes) are presented. These levels are compared with the normal adult levels for the same area or with the levels presented in the literature. The concentrations of 5 trace elements (As, Cu, Hg, Mn, Se) in human milk and 4 brands of artificial milks are also given and the intake of these trace elements from human and artificial milk for infants up to the age of 6 months is calculated. It is concluded that some artificial milks contain less of some essential trace elements (e.g. Cu and Se) and are richer in toxic trace elements (e.g. Hg and As). The suggestion of deficiency of the reported trace elements as a cause of cot deaths is rejected.

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