Immunohistological studies on clinically silent pituitary adenomas

1990 ◽  
Vol 1 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Wolfgang Saeger ◽  
H. Günzl ◽  
Michaela Meyer ◽  
Cornelia Schulze ◽  
Dieter K. Lüdecke
Keyword(s):  
Pituitary Adenomas ◽  
Silent Pituitary Adenomas

scholarly journals Clinical and Pathological Aspects of Silent Pituitary Adenomas

2018 ◽  
Vol 104 (7) ◽  
pp. 2473-2489 ◽  
Author(s):  
Juliana Drummond ◽  
Federico Roncaroli ◽  
Ashley B Grossman ◽  
Márta Korbonits
Keyword(s):  
Pituitary Adenomas ◽  
Silent Pituitary Adenomas

Modification of hormonal secretion in clinically silent pituitary adenomas

Pituitary ◽  
2008 ◽  
Vol 12 (1) ◽  
pp. 80-86 ◽  
Author(s):  
Tania Daems ◽  
Johan Verhelst ◽  
Alex Michotte ◽  
Pascale Abrams ◽  
Dirk De Ridder ◽  
...  
Keyword(s):  
Pituitary Adenomas ◽  
Hormonal Secretion ◽  
Silent Pituitary Adenomas

Abundant hypermethylation of SOCS-1 in clinically silent pituitary adenomas

2006 ◽  
Vol 111 (3) ◽  
pp. 264-271 ◽  
Author(s):  
Rolf Buslei ◽  
Jürgen Kreutzer ◽  
Bernd Hofmann ◽  
Verena Schmidt ◽  
Florian Siebzehnrübl ◽  
...  
Keyword(s):  
Pituitary Adenomas ◽  
Silent Pituitary Adenomas

The immunocytochemical heterogeneity of silent pituitary adenomas

1988 ◽  
Vol 118 (4) ◽  
pp. 533-537 ◽  
Author(s):  
H. M. Heshmati ◽  
G. Turpin ◽  
M. Kujas ◽  
X. Lam ◽  
R. Van Effenterre ◽  
...  
Keyword(s):  
Pituitary Adenomas ◽  
Pituitary Tumour ◽  
Pituitary Hormones ◽  
Glycoprotein Hormones ◽  
Α Subunit ◽  
Melanocyte Stimulating Hormone ◽  
The One ◽  
Silent Pituitary Adenomas ◽  
Secretory Pattern ◽  
Tumour Cell Population

Abstract. An immunocytochemical study was performed by the indirect peroxidase method on the pituitary tumour of 37 patients with clinical and biological signs of silent adenoma. Antisera were used against human PRL, human GH, ACTH1-24, human ACTH17-39, α-melanocyte stimulating hormone (α-MSH), human β-endorphin, α-subunit of hCG (hCG-α), and β-subunits of human LH(LH-β), human FSH (FSH-β) and human TSH (TSH-β). Immunostaining in at least 5% of the tumour cell population, with one or more antisera, was present in 13 cases; hCG-α immunostaining was the one most frequently observed. Combined immunostaining was found in 7 cases. Exclusive immunostaining was present in 6 cases: 4 with hCG-α, 1 with ACTH1-24 and 1 with TSH-β It is concluded that a significant number of silent pituitary adenomas show a certain secretory pattern of pituitary hormones or subunits of glycoprotein hormones as revealed by the immunocytochemistry.

Clinical Relevance and Immunohistochemical Patterns of Silent Pituitary Adenomas: 10 Years of Single-centre Experience

2020 ◽  
Vol 16 ◽  
Author(s):  
Gamze Akkus ◽  
Barış Karagun ◽  
Nuri Eralp Çetinalp ◽  
Arbil Açıkalın ◽  
Mehtap Evran ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Pituitary Adenomas ◽  
Clinical Relevance ◽  
Clinical Status ◽  
Signs And Symptoms ◽  
Pituitary Hormone ◽  
Hormone Production ◽  
Α Subunit ◽  
Mri Features ◽  
Silent Pituitary Adenomas

Background: Silent pituitary adenomas are clinically found to be non-functional (i.e., without clinically evident pituitary hormone production). Introduction: The aim of this study was to investigate subjects with silent pituitary adenomas for possible variations in their clinical status. Methods: A total of 102 patients who had undergone surgery for pituitary adenoma and had been diagnosed with silent pituitary adenoma was included in the study. The patients’ preoperative and postoperative hormonal parameters and magnetic resonance imaging (MRI) features were collected, and pathological specimens were re-evaluated. Results: Immunohistochemistry results of the 102 patients were as follows: hormone-negative adenomas (n=35) 35.5%; FSH+LH-positivity (n=32) 31.3%; ACTH-positivity (n=11) 10.7%; α-subunit-positivity (n= 9) 8.8%; prolactin-positivity (n=8) 7.8%; GH-positivity (n=6) 5.4%; and plurihormonal adenoma (n=1). The mean sizes of SGA, SGHA, and SCA were 28.0±12.7, 30.0±16.0, and 27.7±8.9mm (p>0.05), respectively. With the exception of silent gonadotroph adenomas (SGAs), female gender dominance was shown in patients with silent growth hormone adenoma (SGHA) and silent corticotroph adenoma (SCA). Although no clinical relevance was observed in relation to hormonal excess, preoperative GH (4.21±4.6,vs 0.27±0.36 p=0.00) was slightly more elevated in SGHA than in GH-negative adenomas. Additionally, preoperative basal ACTH values (47.3±28.7 vs 23.9±14.4, p=0.003) were also higher in SCA compared to the other types. Our findings revealed SCAs to be more aggressive behaviour than SGHAs and SGAs due to invasiveness in radiological imaging, their elevated re-operation and postoperative ACTH values. Conclusion: Silent pituitary adenomas represent a challenging diagnostic tumour group. Careful initial evaluation of patients with pituitary adenomas should consider any mild signs and symptoms of functionality, particularly in cases of GH- and ACTH-secreting adenomas.

Silent Pituitary Adenomas

2015 ◽  
Vol 44 (1) ◽  
pp. 79-87 ◽  
Author(s):  
Sarah E. Mayson ◽  
Peter J. Snyder
Keyword(s):  
Pituitary Adenomas ◽  
Silent Pituitary Adenomas

The effects of silent pituitary adenomas on pregnancy

2020 ◽  
Author(s):  
Aksu Özge Baș ◽  
Özgür Demir ◽  
Canpolat Asena Gökçay ◽  
Demet Çorapçıoğlu
Keyword(s):  
Pituitary Adenomas ◽  
Silent Pituitary Adenomas

Ultrastructural Investigation of Spontaneous Pituitary Adenomas in Aging Sprague-Dawley Rats

1982 ◽  
Vol 40 ◽  
pp. 216-217
Author(s):  
D. J. McComb ◽  
J. Beri ◽  
F. Zak ◽  
K. Kovacs
Keyword(s):  
Microscopic Study ◽  
Pituitary Adenomas ◽  
Wistar Rats ◽  
Microscopic Level ◽  
Sprague Dawley ◽  
Prolactin Cells ◽  
Light Microscopic Level ◽  
Ultrastructural Investigation ◽  
Sprague Dawley Rats ◽  
Long Evans

Investigation of the spontaneous pituitary adenomas in rat have been limited mainly to light microscopic study. Furth et al. (1973) described them as chromophobic, secreting prolactin. Kovacs et al. (1977) in an ul trastructural investigation of adenomas of old female Long-Evans rats, found that they were composed of prolactin cells. Berkvens et al. (1980) using immunocytochemistry at the light microscopic level, demonstrated that some spontaneous tumors of old Wistar rats could contain GH, TSH or ACTH as well as PRL.

Sign in / Sign up

Export Citation Format

Share Document