Effects of substance P on human T cell function and the modulatory role of peptidase inhibitors

1997 ◽  
Vol 27 (2-4) ◽  
pp. 129-134 ◽  
Author(s):  
M. J. Covas ◽  
L. A. Pinto ◽  
R. M. M. Victorino
Keyword(s):  
T Cell ◽  
Substance P ◽  
Cell Function ◽  
Peptidase Inhibitors ◽  
T Cell Function ◽  
Human T Cell

Comparative effect of two pan-class I PI3K inhibitors used as anticancer drugs on human T cell function

2015 ◽  
Vol 28 (1) ◽  
pp. 675-685 ◽  
Author(s):  
Belén Blanco ◽  
Carmen Herrero-Sánchez ◽  
Concepción Rodríguez-Serrano ◽  
Mercedes Sánchez-Barba ◽  
María Consuelo del Cañizo
Keyword(s):  
T Cell ◽  
Anticancer Drugs ◽  
Cell Function ◽  
Class I ◽  
Comparative Effect ◽  
Pi3k Inhibitors ◽  
T Cell Function ◽  
Human T Cell

scholarly journals Role of Mechanotransduction and Tension in T Cell Function

2018 ◽  
Vol 9 ◽  
Author(s):  
Jérémie Rossy ◽  
Julia M. Laufer ◽  
Daniel F. Legler
Keyword(s):  
T Cell ◽  
Cell Function ◽  
T Cell Function

Abstract A070: The role of the centrosome in cytotoxic T cell function

2016 ◽  
Author(s):  
Fella Tamzalit ◽  
Ariella Kepecs ◽  
Hisham Bazzi ◽  
Kathryn Anderson ◽  
Morgan Huse
Keyword(s):  
T Cell ◽  
Cell Function ◽  
Cytotoxic T Cell ◽  
T Cell Function

scholarly journals Role of the EHD Family of Endocytic Recycling Regulators for TCR Recycling and T Cell Function

2017 ◽  
Vol 200 (2) ◽  
pp. 483-499 ◽  
Author(s):  
Fany M. Iseka ◽  
Benjamin T. Goetz ◽  
Insha Mushtaq ◽  
Wei An ◽  
Luke R. Cypher ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Function ◽  
Endocytic Recycling ◽  
T Cell Function

scholarly journals Combined Deficiency of p50 and cRel in CD4+ T Cells Reveals an Essential Requirement for Nuclear Factor κB in Regulating Mature T Cell Survival and In Vivo Function

2003 ◽  
Vol 197 (7) ◽  
pp. 861-874 ◽  
Author(s):  
Ye Zheng ◽  
Monika Vig ◽  
Jesse Lyons ◽  
Luk Van Parijs ◽  
Amer A. Beg
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Survival ◽  
Cd4 T Cells ◽  
Cell Function ◽  
Nuclear Factor ◽  
T Cell Function ◽  
T Cell Survival

Signaling pathways involved in regulating T cell proliferation and survival are not well understood. Here we have investigated a possible role of the nuclear factor (NF)-κB pathway in regulating mature T cell function by using CD4+ T cells from p50−/− cRel−/− mice, which exhibit virtually no inducible κB site binding activity. Studies with these mice indicate an essential role of T cell receptor (TCR)-induced NF-κB in regulating interleukin (IL)-2 expression, cell cycle entry, and survival of T cells. Our results further indicate that NF-κB regulates TCR-induced expression of antiapoptotic Bcl-2 family members. Strikingly, retroviral transduction of CD4+ T cells with the NF-κB–inducing IκB kinase β showed that NF-κB activation is not only necessary but also sufficient for T cell survival. In contrast, our results indicate a lack of involvement of NF-κB in both IL-2 and Akt-induced survival pathways. In vivo, p50−/− cRel−/− mice showed impaired superantigen-induced T cell responses as well as decreased numbers of effector/memory and regulatory CD4+ T cells. These findings provide the first demonstration of a role for NF-κB proteins in regulating T cell function in vivo and establish a critically important function of NF-κB in TCR-induced regulation of survival.

Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population

10.1038/72323 ◽  
2000 ◽  
Vol 6 (2) ◽  
pp. 211-214 ◽  
Author(s):  
David E. Anderson ◽  
Katarzyna D. Bieganowska ◽  
Amit Bar-Or ◽  
Enedina M.L. Oliveira ◽  
Beatriz Carreno ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Population ◽  
Cell Function ◽  
T Cell Function ◽  
Human T Cell

scholarly journals ALTERATION OF HUMAN T-CELL FUNCTION AFTER THYMIC IRRADIATION

1974 ◽  
Vol 8 (4) ◽  
pp. 418-418
Author(s):  
Christian H L Rieger ◽  
Simmer C Kraft ◽  
Richard M Rothberg
Keyword(s):  
T Cell ◽  
Cell Function ◽  
T Cell Function ◽  
Human T Cell
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