Immune complexes and IgG-Fc receptors on human platelets in essential mixed cryoglobulinemia

1986 ◽  
Vol 16 (2) ◽  
Author(s):  
Sebastiano Garelli ◽  
Pier Luigi Meroni ◽  
Giuseppina Musmanno ◽  
Wilma Barcellini ◽  
Fulvio Invernizzi
Keyword(s):  
Immune Complexes ◽  
Fc Receptors ◽  
Mixed Cryoglobulinemia ◽  
Human Platelets ◽  
Essential Mixed Cryoglobulinemia

Cryoglobulins and immune complexes in essential mixed cryoglobulinemia

1986 ◽  
Vol 16 (2) ◽  
Author(s):  
Stefano Bombardieri ◽  
Clodoveo Ferri ◽  
Paola Migliorini ◽  
Aldo Pontrandolfo ◽  
Antonio Puccetti ◽  
...  
Keyword(s):  
Immune Complexes ◽  
Mixed Cryoglobulinemia ◽  
Essential Mixed Cryoglobulinemia

Essential Mixed Cryoglobulinemia Possibly Due to Hepatitis Virus

1982 ◽  
Vol 75 (11) ◽  
pp. 1411-1413
Author(s):  
PREM KUMAR ◽  
PAUL CHAKOLA ◽  
ERNESTO HOFFMANN ◽  
STEPHEN LEECH
Keyword(s):  
Hepatitis Virus ◽  
Mixed Cryoglobulinemia ◽  
Essential Mixed Cryoglobulinemia

scholarly journals Differential signal transduction, membrane trafficking, and immune effector functions mediated by FcγRI versus FcγRIIa

Blood ◽  
2009 ◽  
Vol 114 (2) ◽  
pp. 318-327 ◽  
Author(s):  
Xilei Dai ◽  
Manikandan Jayapal ◽  
Hwee Kee Tay ◽  
Renji Reghunathan ◽  
Gen Lin ◽  
...  
Keyword(s):  
Antigen Presentation ◽  
Mhc Class Ii ◽  
Membrane Trafficking ◽  
Immune Complexes ◽  
Antigen Processing ◽  
Fc Receptors ◽  
Nicotinamide Adenine Dinucleotide Phosphate ◽  
Human Leukocyte ◽  
Differential Signal ◽  
Proinflammatory Mediators

Abstract Receptors for the fragment crystallizable region of immunoglobulin-G (FcγRs) play an important role in linking the humoral and cellular arms of the immune response. In this study, we present a comprehensive functional comparison of 2 human Fc-receptors, FcγRI and FcγRIIa. Activation of FcγRI results in a novel signaling cascade that links phospholipase D1 to sphingosine kinase-1 in U937 cells and primary human monocytes. This induces the expression of proinflammatory mediators and is associated with trafficking of immune complexes into human leukocyte antigen-DM positive antigen-processing compartments coupled with improved MHC class II–mediated antigen presentation to T lymphocytes. In contrast, activation of FcγRIIa elicits signaling through phospholipase Cγ1, resulting in increases in intracellular calcium, activation of nicotinamide adenine dinucleotide phosphate-oxidative burst, and differential membrane trafficking combined with impaired antigen presentation and proinflammatory cytokine expression. These data provide a mechanistic insight into the disparate activities associated with Fc receptors in immunity, namely, reinforcement of immune responses through stimulation of proinflammatory signaling and antigen presentation, versus the maintenance of immunologic homeostasis through the noninflammatory clearance of immune complexes.

scholarly journals Activation of human platelets by immune complexes prepared with cationized human IgG

Blood ◽  
1993 ◽  
Vol 82 (10) ◽  
pp. 3045-3051
Author(s):  
M Schattner ◽  
M Lazzari ◽  
AS Trevani ◽  
E Malchiodi ◽  
AC Kempfer ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Platelet Activation ◽  
Immune Complexes ◽  
Platelet Rich Plasma ◽  
Human Platelets ◽  
Human Igg ◽  
Experimental Conditions ◽  
Induce Platelet Aggregation ◽  
Soluble Immune Complexes ◽  
High Concentrations

The present study shows that the ability of soluble immune complexes (IC), prepared with human IgG and rabbit IgG antibodies against human IgG, to trigger platelet activation was markedly higher for IC prepared with cationized human IgG (catIC) compared with those prepared with untreated human IgG (cIC). CatIC induced platelet aggregation and adenosine triphosphate release in washed platelets (WP), gel-filtered platelets (GFP), or platelet-rich plasma (PRP) at physiologic concentrations of platelets (3 x 10(8)/mL) and at low concentrations of catIC (1 to 30 micrograms/mL). On the contrary, under similar experimental conditions, cIC did not induce aggregation in PRP, WP, or GFP. Low aggregation responses were only observed using high concentrations of both WP (9 x 10(8)/mL) and cIC (500 micrograms/mL). Interestingly, catIC were also able to induce platelet activation under nonaggregating conditions, as evidenced by P-selectin expression. Cationized human IgG alone did not induce platelet aggregation in PRP but triggered either WP or GFP aggregation. However, the concentration needed to induce these responses, was about eightfold higher than those required for catIC. The responses induced either by catIC or cationized human IgG were completely inhibited by treatment with heparin, dextran sulphate, EDTA, prostaglandin E1, or IV3, a monoclonal antibody against the receptor II for the Fc portion of IgG (Fc gamma RII). The data presented in this study suggest that IgG charge constitutes a critical property that conditions the ability of IC to trigger platelet activation.

Liver involvement in essential mixed cryoglobulinemia

1979 ◽  
Vol 9 (4) ◽  
Author(s):  
Stefano Bombardieri ◽  
Clodoveo Ferri ◽  
Ombretta Di Munno ◽  
Giampiero Pasero
Keyword(s):  
Mixed Cryoglobulinemia ◽  
Liver Involvement ◽  
Essential Mixed Cryoglobulinemia
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