Clinical evaluation of the99mTc-diethyl-HIDA plasma clearance curve and observations on the third exponential term

1983 ◽  
Vol 13 (4) ◽  
pp. 487-490
Author(s):  
Evaristo Di Rocco ◽  
Mauro Liberatore ◽  
Francesco Scopinaro ◽  
Antonio Centi Colella
Keyword(s):  
Clinical Evaluation ◽  
Plasma Clearance ◽  
Clearance Curve ◽  
Exponential Term ◽  
The Third

scholarly journals A Recurrence of a Giant Odontogenic Keratocyst: Radiographic Follow-Up

2018 ◽  
Vol 1 (1) ◽  
pp. 42-46
Author(s):  
Luis Alberto Mendez ◽  
Ricardo Martinez ◽  
David Josue Echavarria ◽  
Raul Antonio Gonzalez
Keyword(s):  
Periodontal Disease ◽  
Clinical Evaluation ◽  
Surgical Excision ◽  
The Body ◽  
Dental School ◽  
Odontogenic Keratocyst ◽  
Imaging Studies ◽  
Central Lesion ◽  
The Third

Odontogenic keratocyst could be a very aggressive lesion which may be imperceptible for the patient, not giving any type of symptomatology. This is usually discovered as a finding during a clinical evaluation of the maxillofacial area. The diagnosis of this lesion is merely histological, although it has some radiographic features that presumptively indicate the diagnosis. During a dental school brigade a patient came referring dental mobility, periodontal disease was absent and oral examination revealed a large swelling identified in the body of the mandible. Imaging studies revealed a large central lesion diagnosed as OKC when biopsy was performed. After enucleation and curettage of the lesion radiographic follow-up was conducted every six months, at the third six month period recurrence of the lesion was present and surgical excision was performed with the recommendation of and strict radiographic follow-up in quarterly periods.

scholarly journals MON-101 Costa Rican National Primary Congenital Hypothyroidism Screening Program Evaluation. Retrospective Cohort Trial Between 2015 and 2017

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Alejandro Cob ◽  
Fred Cavallo Aita ◽  
Agnes Rodríguez
Keyword(s):  
Newborn Screening ◽  
Sensitivity And Specificity ◽  
Congenital Hypothyroidism ◽  
Clinical Evaluation ◽  
Screening Test ◽  
Screening Program ◽  
Costa Rican ◽  
International Standards ◽  
Newborn Screening Program ◽  
The Third

Abstract Congenital hypothyroidism (CH) is one of the leading causes of intellectual impairment worldwide in infancy. The newborn screening has been able to prevent this mental disability, by a prompt initiation of therapy. Over the last years the incidence of HC has been increasing, mainly by lowering the screening cut-off level that leads to detection of milder cases. There is conflicting evidence if children with mild CH without treatment may develop neurological impairment in the future. Costa Rican newborn screening program in divided in three stages, measuring serum TSH concentrations from a heel prick aliquot of capillary blood dried onto a filter paper. Each test has different TSH cut-off values to determine if the newborn needs a clinical evaluation by an endocrinologist, needs another screening test or rules out hypothyroidism. We developed an observational, descriptive, retrospective study, based on medical records, to evaluate our newborn screening program performance. The study included the total national population of screened newborns from 2015 to 2017. Descriptive analysis and analytical analysis of variables were done, and test’s sensitivity and specificity were determined. The study analyzed 204.241 screened newborns, and 145 children referred to the Endocrinology Department of the National Children Hospital. This population represents 97% of births in these 3 years. The recall rate for a first positive test was 0.3%. Congenital hypothyroidism was confirmed in 73% of children referred to the Endocrinology Department because of a positive screening. Incidence was 1/1926 births. Detection rate was independent of birth weight nor gestational age. 45.3% of children diagnosed with CH were detected after the first screening test, 52.8% after the second screening test and 1.9% after the third screening test. Screening test analysis showed high sensitivity and specificity, with diagnostic accuracy above 90%, except for the third screening test. Free thyroxine measurements alone weren’t useful to predict CH diagnosis. The coverage of the national neonatal screening program extends almost to the entire population. Our test specificity is within international standards. Incidence of CH in Costa Rica is similar to that reported in medical literature. With current detection cut-off level, there is no need of performing a second mandatory evaluation to preterm and low weight newborns. The third screening test has a low performance rate, does not improve detection of children with CH significantly, and delays clinical evaluation by the endocrinologist. Prognosis of treated children with CH is excellent, with no evidence of severe cognitive deficit.

Comparative Kinetics of Microvascular Inulin and 99mTc-Labelled Diethylenetriaminepenta-Acetic Acid Exchange

1997 ◽  
Vol 93 (5) ◽  
pp. 471-477 ◽  
Author(s):  
C. Cousins ◽  
R. D. Gunasekera ◽  
M. Mubashar ◽  
S. Mohammadtaghi ◽  
R. Strong ◽  
...  
Keyword(s):  
Intravenous Injection ◽  
Plasma Clearance ◽  
Interstitial Space ◽  
Second Phase ◽  
Time Activity ◽  
Deconvolution Analysis ◽  
Clearance Curve ◽  
Extraction Fraction ◽  
Time Courses ◽  
Arterial Plasma

1. After simultaneous intravenous injection as a mixture, 99mTc-labelled diethylenetriaminepentaacetic acid (99mTc-DTPA; molecular mass 492 Da) and inulin (∼6000 Da) gave arterial plasma clearance curves consisting of three exponentials, the time courses of which were not significantly different between the two solutes. 2. The ratio of 99mTc-DTPA to inuiin concentration in antecubital venous plasma (normalized to the ratio in arterial plasma at 30 s) was 0.6, significantly less than unity, within 2 min after intravenous injection, but increased to reach unity by 60 min. The minimun concentration ratio of 99mTc-DTPA to inulin in arterial plasma was 0.75 at 4 min, also rising to just above unity at 60 min. 3. The extraction fraction from plasma to interstitial space was higher for 99mTc-DTPA (∼0.5) than for inuiin (∼0.2). For both solutes, the net extraction fraction decreased with time, becoming negative at about 25 min after injection. Thereafter, the net extraction fractions remained negative, between −0.05 and −0.1, and not significantly different between the two solutes. 4. 99mTc-DTPA time—activity curves recorded over the limbs with scintillation probes were biphasic, with an initial phase corresponding closely in time with the first exponential of the arterial 99mTc-DTPA plasma clearance curve. The second phase corresponded in time to the intermediate exponential of the arterial 99mTc-DTPA plasma clearance curve. 5. The time course of net 99mTcm-DTPA extraction fraction across the forearm vascular bed was bi-exponential, with phases corresponding in time with the two phases of the limb uptake curves. 6. Deconvolution analysis of the limb time—activity curves, using the arterial time—concentration curve as the input function, gave bi-exponential 99mTc-DTPA impulse response curves in which the time courses of the exponentials corresponded with the first and intermediate exponentials of the arterial 99mTc-DTPA clearance curve. 7. The bi-exponential nature of the equilibrium of 99mTc-DTPA between vascular and interstitial compartments suggests the presence of two separate functional volumes within the interstitial space. Although 99mTc-DTPA and inuiin clearly diffuse at different rates across the endothelium, as would be expected from their disparate sizes, the similarity in the time courses of their initial exponentials and simultaneous equalization of transfer rates (i.e. when net extraction fraction was zero) is consistent with the hypothesis that inuiin moves initially into a smaller functional interstitial fluid volume than 99mTc-DTPA. The total distribution volumes, however, are not significantly different between the two solutes.

scholarly journals Clinical Evaluation of Post-Extraction Site Wound Healing

2006 ◽  
Vol 7 (3) ◽  
pp. 40-49 ◽  
Author(s):  
Wasiu Lanre Adeyemo ◽  
Akinola Ladipo Ladeinde ◽  
Mobolanle Olugbemiga Ogunlewe
Keyword(s):  
Wound Healing ◽  
Clinical Evaluation ◽  
Tooth Extraction ◽  
Assessment Data ◽  
Age And Gender ◽  
The Third ◽  
Extraction Site ◽  
Alveolar Osteitis ◽  
And Gender ◽  
Healing Assessment

Abstract Aim The aim of this prospective study was to evaluate the clinical pattern of post-extraction wound healing with a view to identify the types, incidence, and pattern of healing complications following non-surgical tooth extraction. Study Design A total of 311 patients, who were referred for non-surgical (intra-alveolar) extractions, were included in the study. The relevant pre-operative information recorded for each patient included age and gender of the patient, indications for extraction, and tooth/teeth removed. Extractions were performed under local anesthesia with dental forceps, elevators, or both. Patients were evaluated on the third and seventh postoperative days for alveolus healing assessment. Data recorded were: biodata, day of presentation for alveolus healing assessment, day of onset of any symptoms, body temperature (°C) in cases of alveolus infection, and presence or absence of pain. Results Two hundred eighty-two patients (282) with 318 extraction sites were evaluated for alveolus healing. Healing was uneventful in 283 alveoli (89%), while 35 alveoli (11%) developed healing complications. These complications were: localized osteitis 26 (8.2%); acutely infected alveolus 5 (1.6%); and an acutely inflamed alveolus 4 (1.2%). Females developed more complications than males (p=0.003). Most complications were found in molars (60%) and premolars (37.1%). Localized osteitis caused severe pain in all cases, while infected and inflamed alveolus caused mild or no pain. Thirty patients (12%) among those without healing complications experienced mild pain. Conclusions Most of the post-extraction alveoli healed uneventfully. Apart from alveolar osteitis (AO), post-extraction alveolus healing was also complicated by acutely infected alveoli and acutely inflamed alveoli. This study also demonstrated a painful alveolus is not necessarily a disturbance of post-extraction site wound healing; a thorough clinical examination must, therefore, be made to exclude any of the complications. Citation Adeyemo WL, Ladeinde AL, Ogunlewe MO. Clinical Evaluation of Post-extraction Site Wound Healing. J Contemp Dent Pract 2006 July;(7)3:040-049.

scholarly journals Maxillary mucocele – unusual localization

2020 ◽  
Vol 2 (7) ◽  
pp. 01-03
Author(s):  
Carlos Zappelini
Keyword(s):  
Maxillary Sinus ◽  
Clinical Evaluation ◽  
Paranasal Sinuses ◽  
Rare Case ◽  
Respiratory Epithelium ◽  
Diagnosis And Treatment ◽  
Definitive Treatment ◽  
Cystic Lesions ◽  
The Third

Mucoceles of the paranasal sinuses are benign expansive cystic lesions, originated from the obstruction of the nasal drainage, have mucous or mucopurulent secretions and are covered by respiratory epithelium. Its development is insidious, generally unilateral and has a higher incidence between the third and fourth decades of life, with no gender predilection. Objective: To present a rare case of mucocele in the maxillary sinus, addressing the methods used in diagnosis and treatment. Final comments: The clinical evaluation associated with imaging tests suggest the diagnosis of mucoceles and the definitive treatment must be surgical.

scholarly journals Application of the laser radiation in patients of pressure ulcers: clinical and histomorphometric analysis of the derm

2008 ◽  
Vol 51 (spe) ◽  
pp. 231-234 ◽  
Author(s):  
José Carlos Tatmatsu Rocha ◽  
Maria Tereza Jansem de Almeida Catanho ◽  
Diógenes Luís da Mota
Keyword(s):  
Quantitative Analysis ◽  
Laser Radiation ◽  
Laser Irradiation ◽  
Clinical Evaluation ◽  
Tissue Regeneration ◽  
Granulation Tissue ◽  
Pressure Ulcers ◽  
Histomorphometric Analysis ◽  
The Third

In this work, we analyze the clinical alterations and histological modifications in patients with not infect ulcers of pressure, submitted to the Laser irradiation GaAs (wavelength 904 nm, doses 3 J/cm², during 1 minute and prompt application) during 5 days consecutive and as a group radiated during 15 days alternating. In the clinical evaluation after the laser irradiation observed presence of exudation, granulation tissue and points of bleed after the third day of irradiation. The computerized morph quantitative analysis demonstrated that submitted to the laser irradiation during the 15 days busy area for the 4115,922 vases was of µm², and in the radiated ones during 5 4348,253 days of µm², both in a 0,25 area of cm² of derma. The gotten results suggest that this therapeutically one was efficient as to assist in the processes of tissue regeneration in the patients treated in the research.

The Kinetics of Organic Anion Excretion by the Liver in Acute Intermittent Porphyria

1970 ◽  
Vol 38 (6) ◽  
pp. 677-686 ◽  
Author(s):  
J. A. Stein ◽  
J. R. Bloomer ◽  
P. D. Berk ◽  
P. L. Corcoran ◽  
D. P. Tschudy
Keyword(s):  
Indocyanine Green ◽  
Liver Cell ◽  
Plasma Clearance ◽  
Organic Anion ◽  
Acute Intermittent Porphyria ◽  
Clearance Curve ◽  
Exponential Component ◽  
Asymptomatic Patients ◽  
Kinetics Of ◽  
Bsp Uptake

1. The kinetics of disappearance from the blood of three organic anions were studied in patients with acute intermittent porphyria. Indocyanine green (ICG) and [14C]bilirubin were cleared normally in this disease, whereas bromsulphthalein (BSP) was cleared at less than the normal rate. The first exponential component of the BSP clearance curve was normal in acute intermittent porphyria, but the second exponential component declined less rapidly than in normals. The abnormality was greater in symptomatic than in asymptomatic patients, but both groups were significantly different from normals. 2. The data are discussed in terms of a previously published model of BSP metabolism. The findings suggest normal BSP uptake initially by the liver with increased regurgitation of dye into the blood and decreased excretion of BSP from the liver cell into the bile. 3. In contrast to human acute intermittent porphyria, plasma clearance of BSP was greatly increased in experimental porphyria. This was associated with an increased level of BSP conjugating enzyme in the liver in experimental porphyria. 4. The BSP retention in acute intermittent porphyria, along with certain other findings, raises the question of the existence of an ‘oestrogen effect’ in this disease, but further studies will be required to determine whether the mechanism of BSP retention is identical to that produced by oestrogen.

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