The expanding spectrum of clinical and laboratory features of IgE myeloma

1980 ◽  
Vol 10 (4) ◽  
Author(s):  
Franco Dammacco ◽  
Antonio Miglietta ◽  
Maurizio Tribalto ◽  
Franco Mandelli ◽  
Lorenzo Bonomo
Keyword(s):  
Laboratory Features ◽  
Ige Myeloma

Geoepidemiology, clinical and laboratory features of imported transmissible infections in Saint Petersburg

2019 ◽  
Vol 17 (8) ◽  
pp. 17-23
Author(s):  
K. E. Novak ◽  
◽  
E. V Esaulenko ◽  
A. G. Dyachkov ◽  
V. B. Musatov ◽  
...  
Keyword(s):  
Saint Petersburg ◽  
Laboratory Features

Rapid Aetiological Diagnosis of Pneumonia Based on Routine Laboratory Features

1990 ◽  
Vol 22 (5) ◽  
pp. 537-545 ◽  
Author(s):  
Hans Holmberg ◽  
Lennart Bodin ◽  
Ingegerd Jönsson ◽  
Aud Krook
Keyword(s):  
Routine Laboratory ◽  
Laboratory Features ◽  
Aetiological Diagnosis

scholarly journals Clinical and laboratory features of brucellosis in a university hospital in Tunisia

2021 ◽  
Author(s):  
H Battikh ◽  
A Berriche ◽  
R Zayoud ◽  
L Ammari ◽  
R Abdelmalek ◽  
...  
Keyword(s):  
University Hospital ◽  
Laboratory Features

scholarly journals REVIEW OF CLINICAL AND LABORATORY FEATURES OF HUMAN BRUCELLOSIS

2007 ◽  
Vol 25 (3) ◽  
pp. 188-202
Author(s):  
BG Mantur ◽  
SK Amarnath ◽  
RS Shinde
Keyword(s):  
Human Brucellosis ◽  
Laboratory Features

Characterization and outcome of 11 children with non-diabetic ketoacidosis

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Elsayed Abdelkreem ◽  
Rofaida M. Magdy ◽  
Abdelrahim A. Sadek
Keyword(s):  
Diabetic Ketoacidosis ◽  
Case Series ◽  
Inborn Errors ◽  
Laboratory Features ◽  
Level 3 ◽  
Conscious Level ◽  
Neurodevelopmental Impairment ◽  
Salicylate Intoxication ◽  
Prompt Diagnosis

AbstractObjectivesTo study the clinical and laboratory features, management, and outcome of pediatric non-diabetic ketoacidosis (NDKA).MethodsBetween May 2018 and April 2020, we prospectively collected children under 18 years who presented with ketoacidosis, defined as ketosis (urinary ketones ≥++ and/or serum β-hydroxybutyrate level ≥3 mmol/L) and metabolic acidosis (pH <7.3 and HCO3− <15 mmol/L). Children with HbA1c level ≥6.5% at initial presentation and those meeting the diagnostic criteria for DM during follow-up were excluded. Data were collected on demographics, clinical and laboratory features, management, and outcome.ResultsEleven children with 19 episodes of NDKA were identified. The median age was 12 months (range from 5 months to 5 years). They manifested dehydration and disturbed conscious level (all cases), convulsions (n=6), hypoglycemia (n=6), hyperglycemia (n=2) and significant hyperammonemia (n=4). Most cases required intensive care management. Death or neurodevelopmental impairment occurred in six cases. Seven cases had inborn errors of metabolism (IEMs). Other cases were attributed to starvation, sepsis, and salicylate intoxication.ConclusionsThis is the largest case series of pediatric NDKA. Ketoacidosis, even with hyperglycemia, is not always secondary to diabetes mellitus. IEMs may constitute a significant portion of pediatric NDKA. Increased awareness of this unfamiliar condition is important for prompt diagnosis, timely management, and better outcome.

scholarly journals FRI0480 SCHNITZLER’S SYNDROME: DESCRIPTION OF AN ITALIAN MULTICENTER COHORT

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 837.1-837
Author(s):  
F. Crisafulli ◽  
P. Airò ◽  
F. Franceschini ◽  
A. Tincani ◽  
M. Frassi
Keyword(s):  
Monoclonal Gammopathy ◽  
Interleukin 1 ◽  
Diagnostic Delay ◽  
Injection Site Reaction ◽  
Lymphoproliferative Disease ◽  
Severe Allergic Reaction ◽  
Intermittent Fever ◽  
Multicenter Cohort ◽  
Laboratory Features ◽  
Schnitzler’S Syndrome

Background:Schnitzler’s syndrome is an autoinflammatory disease characterized by monoclonal gammopathy and recurrent episodes of urticaria accompanied by clinical and laboratory signs of acute inflammation. Although the exact pathogenic mechanisms have not been fully clarified, the role of Interleukin-1 seems to be central.Objectives:To describe clinical features and therapeutic approach in patients with Schnitzler’s Syndrome.Methods:Retrospective analysis of an Italian multicenter cohort. Data are expressed as the median (IQR).Results:The clinical data of 24 patients from 9 centers (median follow-up 6 years [2-10]; median age at diagnosis 56.5 years [51.25-64.25]) were collected. The median diagnostic delay was 2 years (0-10); the diagnosis was made consensually at the onset of symptoms in 4 cases. The main clinical and laboratory features are shown in Table 1. Therapeutic response was evaluable in 20 patients: all received corticosteroids (CS; 25mg/day [25-50]); in one case, a good clinical response was observed. Eight patients were initially treated with colchicine: in 3 cases it was effective in controlling symptoms and reducing the dose of CS; other 8 patients were treated with csDMARDs (n:1 [1-2]): only 1 patient had a good response to cyclosporin.Table 1.Clinical and laboratory featuresChronic Urticarial Rash, n (%)24/24 (100)Pruritus, n (%)17/24 (71)Intermittent fever, n (%)23/24 (96)Arthralgia/Arthritis, n (%)20/24 (83)Bone pain, n (%)8/24 (33)Weight loss, n (%)9/24 (38)Angioedema, n (%)4/24 (17)Lymphoadenopathy, n (%)7/24 (29)Hepatomegaly, n (%)3/24 (12)Splenomegaly, n (%)3/24 (12)Neuropathy, n (%)4/24 (17)Raised ESR or CRP, n (%)24/24 (100)Leukocytosis, n (%)17/24 (71)Anemia, n (%)9/24 (38)Monoclonal GammopathyIgG λ, n (%)5/22 (23)IgG κ, n (%)6/22 (27)IgM λ, n (%)1/22 (5)IgM κ, n (%)12/22 (55)Bence Jones Protein, n (%)6/23 (26)A bDMARD was initiated in 15 patients. In 7 of the 14 patients initially treated with anakinra this therapy was continued with benefit whereas in the other 7 patients the treatment was discontinued for primary inefficacy (1 patient), secondary inefficacy (3 patients) and adverse events (3 patients; 2 injection site reaction, 1 severe allergic reaction). After anakinra discontinuation, 5 patients were treated with canakinumab with a good response in 3 cases and a partial response in 1 case (persistent arthritis); 1 patient died during the treatment. No response was observed in 3 patients treated with TNF inhibitors as a 2ndor 3rdline bDMARDs, as well as in 1 case initially treated with tocilizumab (in which a good response was afterwards obtained with canakinumab). bDMARDs were associated with a csDMARD in 2 patients (methotrexate and methotrexate + cyclosporine).In one case monoclonal gammopathy evolved into Multiple Myeloma and the patient died 15 years after the onset of symptoms. Idiopathic myelofibrosis and myelodysplasia were found in one and in two patients, respectively.Conclusion:In most cases csDMARDs and bDMARDs like anti-IL6 and anti-TNFα were not able to control the disease. In contrast, in some cases, a good response to colchicine was observed; refractory patients may be successfully treated with anti-IL1 agents. Patients should be supervised for possible evolution towards lymphoproliferative disease.Disclosure of Interests:None declared

scholarly journals Rickets in Children: An Update

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 738
Author(s):  
Cristina Gentile ◽  
Francesco Chiarelli
Keyword(s):  
Vitamin D ◽  
Physical Examination ◽  
Vitamin D Deficiency ◽  
Preventive Measures ◽  
Rapid Diagnosis ◽  
Common Disease ◽  
Biochemical Tests ◽  
Nutritional Rickets ◽  
Laboratory Features ◽  
Radiologic Features

Rickets refers to a deficient mineralization of the growth plate cartilage, predominantly affecting longer bones. Despite the fact that preventive measures are available, it is still a common disease worldwide; nutritional rickets, due to vitamin D deficiency or dietary calcium inadequate intake, remains the most common form. Medical history, physical examination, radiologic features and biochemical tests are essential for diagnosis. Although recent studies suggest hypophosphatemia as the leading alteration, rickets is classically divided into two categories: calcipenic rickets and phosphopenic rickets. Knowledge of this categorization and of respective clinical and laboratory features is essential for rapid diagnosis and correct management. The aim of this review is to analyze the epidemiological, pathogenetic, clinical, and therapeutic aspects of the different forms of rickets, describing the novelties on this “long-lived” disease.

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