Microarray-based differential expression monitoring of 79 novel genes in human fetal tissues

2003 ◽  
Vol 8 (1) ◽  
pp. 125-129
Author(s):  
Ma Shu-hua ◽  
Wang Dun-cheng ◽  
Shen Bei-fen ◽  
Wang Sheng-qi
Pharmacology ◽  
1985 ◽  
Vol 30 (4) ◽  
pp. 188-196 ◽  
Author(s):  
G.M. Pacifici ◽  
H. Glaumann ◽  
A. Rane°

2008 ◽  
Vol 198 (3) ◽  
pp. 325.e1-325.e6 ◽  
Author(s):  
Anna Maria Jonsson ◽  
Mehmet Uzunel ◽  
Cecilia Götherström ◽  
Nikos Papadogiannakis ◽  
Magnus Westgren

1994 ◽  
Vol 78 (1) ◽  
pp. 234-236
Author(s):  
C R Parker ◽  
C N Falany ◽  
C R Stockard ◽  
A K Stankovic ◽  
W E Grizzle

2019 ◽  
Vol 5 (5) ◽  
pp. eaaw1271 ◽  
Author(s):  
Ewart Kuijk ◽  
Francis Blokzijl ◽  
Myrthe Jager ◽  
Nicolle Besselink ◽  
Sander Boymans ◽  
...  

A developing human fetus needs to balance rapid cellular expansion with maintaining genomic stability. Here, we accurately quantified and characterized somatic mutation accumulation in fetal tissues by analyzing individual stem cells from human fetal liver and intestine. Fetal mutation rates were about fivefold higher than in tissue-matched adult stem cells. The mutational landscape of fetal intestinal stem cells resembled that of adult intestinal stem cells, while the mutation spectrum of fetal liver stem cells is distinct from stem cells of the fetal intestine and the adult liver. Our analyses indicate that variation in mutational mechanisms, including oxidative stress and spontaneous deamination of methylated cytosines, contributes to the observed divergence in mutation accumulation patterns and drives genetic mosaicism in humans.


1991 ◽  
Vol 73 (5) ◽  
pp. 1134-1140 ◽  
Author(s):  
LEON MILEWICH ◽  
CYNTHIA E. SHAW ◽  
KATHLEEN M. DOODY ◽  
WILLIAM E. RAINEY ◽  
J. IAN MASON ◽  
...  

1974 ◽  
Vol 1 (5-6) ◽  
pp. 495-504 ◽  
Author(s):  
L. F. Congote ◽  
Samuel Solomon

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