Gonadotropin releasing hormone in first trimester human placenta: Isolation, partial characterisation andin vitro biosynthesis

1986 ◽  
Vol 10 (4) ◽  
pp. 429-441 ◽  
Author(s):  
N. Mathialagan ◽  
A. Jagannadha Rao
Keyword(s):  
Human Placenta ◽  
First Trimester ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Partial Characterisation

Gonadotropin-releasing hormone, inhibin, and activin in human placenta: evidence for a common cellular localization.

1992 ◽  
Vol 74 (5) ◽  
pp. 1184-1188
Author(s):  
F Petraglia ◽  
T K Woodruff ◽  
G Botticelli ◽  
A Botticelli ◽  
A R Genazzani ◽  
...  
Keyword(s):  
Human Placenta ◽  
Cellular Localization ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone

Gonadotropin-releasing hormone-regulated chemokine expression in human placentation

2009 ◽  
Vol 297 (1) ◽  
pp. C17-C27 ◽  
Author(s):  
P. Craig Cavanagh ◽  
Caroline Dunk ◽  
Macarena Pampillo ◽  
Jacob M. Szereszewski ◽  
Jay E. Taylor ◽  
...  
Keyword(s):  
Time Course ◽  
First Trimester ◽  
Gonadotropin Releasing Hormone ◽  
Dependent Manner ◽  
Secondary Effects ◽  
Releasing Hormone ◽  
Uterine Natural Killer Cells ◽  
First Trimester Of Pregnancy ◽  
Maternal Fetal Interface

Placental expression of gonadotropin-releasing hormone (GnRH)-I and II, as well as their cognate receptor, coincides with a period of extensive remodeling of the maternal-fetal interface, near the end of the first trimester of pregnancy. To further define the role of GnRH in human placentation, we performed a microarray screen of HTR-8/SVneo trophoblasts to identify GnRH-regulated genes and their roles in placentation. This screen revealed that GnRH regulates the expression of four angiogenic chemokines: CXCL2, CXCL3, CXCL6, and CXCL8. The microarray data were subsequently confirmed by an extensive Q-PCR time-course analysis. CXCL8, a representative chemokine, was selected for further analysis and shown to be strongly expressed by trophoblasts at the maternal-fetal interface of the human placenta, as well as to accumulate in a GnRH-dependent manner in trophoblast-conditioned media in culture. Trophoblasts were subsequently shown to recruit lymphocytes (Jurkat T cells and primary peripheral blood T and uterine natural killer cells) in chemotaxis assays and this was shown to be GnRH dependent. Furthermore, this recruitment was shown to occur via the release of CXCR1/CXCR2 interacting chemokines, such as the CXCLs investigated in this study. This novel regulation of chemokines by GnRH signaling demonstrates the role of GnRH in regulating the recruitment of lymphocytes to the decidua and the possibility of a direct effect on spiral artery remodeling via the release of proangiogenic chemokines and secondary effects via release of angiogenic factors by recruited lymphocytes.

186: Neoadjuvant Gonadotropin-Releasing Hormone Therapy Before Orchiopexy Improves the Fertility Index in Concomitant Testicular Biopsies

2004 ◽  
Vol 171 (4S) ◽  
pp. 49-49
Author(s):  
Christian Schwentner ◽  
Andreas Lunacek ◽  
Josef Oswald ◽  
Georg Bartsch ◽  
Alfons Kreczy ◽  
...  
Keyword(s):  
Hormone Therapy ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Fertility Index
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