Properties of bovine nephritogenic antigen that induces anti-GBM nephritis in rats and its similarity to the Goodpasture antigen

1991 ◽  
Vol 60 (1) ◽  
pp. 345-351 ◽  
Author(s):  
Yoshikazu Sado ◽  
Megumi Kagawa ◽  
Ichiro Naito ◽  
Tohru Okigaki
Keyword(s):  
Goodpasture Antigen

scholarly journals Physical and immunochemical studies of the globular domain of type IV collagen. Cryptic properties of the Goodpasture antigen.

1985 ◽  
Vol 260 (14) ◽  
pp. 8564-8570 ◽  
Author(s):  
J Wieslander ◽  
J Langeveld ◽  
R Butkowski ◽  
M Jodlowski ◽  
M Noelken ◽  
...  
Keyword(s):  
Type Iv Collagen ◽  
Globular Domain ◽  
Type Iv ◽  
Goodpasture Antigen

scholarly journals The pathogenicity of T cell epitopes on human Goodpasture antigen and its critical amino acid motif

2017 ◽  
Vol 21 (9) ◽  
pp. 2117-2128 ◽  
Author(s):  
Shui-yi Hu ◽  
Qiu-hua Gu ◽  
Jia Wang ◽  
Miao Wang ◽  
Xiao-yu Jia ◽  
...  
Keyword(s):  
Amino Acid ◽  
T Cell ◽  
T Cell Epitopes ◽  
Amino Acid Motif ◽  
Critical Amino Acid ◽  
Goodpasture Antigen

HLA-DR15-specific inhibition attenuates autoreactivity to the Goodpasture antigen

2019 ◽  
Vol 103 ◽  
pp. 102276 ◽  
Author(s):  
Megan Huynh ◽  
Peter J. Eggenhuizen ◽  
Gary L. Olson ◽  
N. Bhaskara Rao ◽  
Christopher R. Self ◽  
...  
Keyword(s):  
Specific Inhibition ◽  
Goodpasture Antigen

scholarly journals Role of regulatory T cells in experimental autoimmune glomerulonephritis

2019 ◽  
Vol 316 (3) ◽  
pp. F572-F581 ◽  
Author(s):  
Stefanie Klinge ◽  
Karsten Yan ◽  
Daniel Reimers ◽  
Karen-Maria Brede ◽  
Joanna Schmid ◽  
...  
Keyword(s):  
T Cells ◽  
Crescentic Glomerulonephritis ◽  
Treg Cells ◽  
Peripheral Tolerance ◽  
Rapid Loss ◽  
Type Iv ◽  
Forkhead Box ◽  
Goodpasture Antigen ◽  
Experimental Autoimmune

Anti-glomerular basement membrane (anti-GBM) disease is characterized by antibodies and T cells directed against the Goodpasture antigen, the noncollagenous domain of the α3-chain of type IV collagen [α3(IV)NC1] of the GBM. Consequences are the deposition of autoantibodies along the GBM and the development of crescentic glomerulonephritis (GN) with rapid loss of renal function. Forkhead box protein P3 (Foxp3)+ regulatory T (Treg) cells are crucial for the maintenance of peripheral tolerance to self-antigens and the prevention of immunopathology. Here, we use the mouse model of experimental autoimmune GN to characterize the role of Treg cells in anti-GBM disease. Immunization of DBA/1 mice with α3(IV)NC1 induced the formation of α3(IV)NC1-specific T cells and antibodies and, after 8–10 wk, the development of crescentic GN. Immunization resulted in increased frequencies of peripheral Treg cells and renal accumulation of these cells in the stage of acute GN. Depletion of Treg cells during immunization led to enhanced generation of α3(IV)NC1-specific antibodies and T cells and to aggravated GN. In contrast, depletion or expansion of the Treg cell population in mice with established autoimmunity had only minor consequences for renal inflammation and did not alter the severity of GN. In conclusion, our results indicate that in anti-GBM disease, Treg cells restrict the induction of autoimmunity against α3(IV)NC1. However, Treg cells are inefficient in preventing crescentic GN after autoimmunity has been established.

Laminin, Fibronectin, and Goodpasture Antigen Detection in Patients with Alport's Syndrome

Renal Failure ◽  
1993 ◽  
Vol 15 (4) ◽  
pp. 503-508 ◽  
Author(s):  
Gordana Basta-Jovanovic ◽  
Marina Savin ◽  
A. Zivorad Jovanovic ◽  
Radoje Veljovic ◽  
Miodrag Sindjic
Keyword(s):  
Antigen Detection ◽  
Alport's Syndrome ◽  
Alport’S Syndrome ◽  
Goodpasture Antigen

scholarly journals The ceramide transporter and the Goodpasture antigen binding protein: one protein - one function?

2010 ◽  
Author(s):  
Chiara Mencarelli ◽  
Mario Losen ◽  
Caroline Hammels ◽  
Jochen De Vry ◽  
Matthijs K. C. Hesselink ◽  
...  
Keyword(s):  
Binding Protein ◽  
Antigen Binding ◽  
Goodpasture Antigen

scholarly journals Phosphorylation of the Goodpasture Antigen by Type A Protein Kinases

1995 ◽  
Vol 270 (22) ◽  
pp. 13254-13261 ◽  
Author(s):  
Fernando Revert ◽  
José R. Penadés ◽  
Mara Plana ◽  
Dolores Bernal ◽  
Charlott Johansson ◽  
...  
Keyword(s):  
Protein Kinases ◽  
Type A ◽  
Goodpasture Antigen
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