Natural killer (NK) activity of cultured S100β-positive T-leukemia cells

1990 ◽  
Vol 59 (1) ◽  
pp. 159-164 ◽  
Author(s):  
Kiyoshi Takahashi ◽  
Tadashi Yoshino ◽  
Tadaatsu Akagi ◽  
Katsuya Miyatani ◽  
Kazuhiko Hayashi ◽  
...  
Keyword(s):  
Natural Killer ◽  
Leukemia Cells ◽  
Nk Activity

Regulation of mouse natural killer (NK) activity by interferon-γ (IFN-γ)

1985 ◽  
Vol 7 (3) ◽  
pp. 327
Author(s):  
F. Velotti ◽  
A. Santoni ◽  
F. Cofano ◽  
S. Landolfo ◽  
M. Piccoli ◽  
...  
Keyword(s):  
Natural Killer ◽  
Interferon Γ ◽  
Nk Activity ◽  
Ifn Γ

Lysis of human B-lymphocyte-derived lymphoma/leukemia cells of established cell lines by interferon-activated natural killer (NK) cells

1981 ◽  
Vol 28 (4) ◽  
pp. 459-468 ◽  
Author(s):  
Paul K. Pattengale ◽  
Magnus Gidlund ◽  
Kenneth Nilsson ◽  
Christer Sundström ◽  
Anders Örn ◽  
...  
Keyword(s):  
Nk Cells ◽  
Natural Killer ◽  
Cell Lines ◽  
B Lymphocyte ◽  
Leukemia Cells ◽  
Established Cell Lines ◽  
Established Cell

scholarly journals Decreased natural killer (NK) activity in patients with myeloproliferative disorders

Cancer ◽  
1989 ◽  
Vol 64 (5) ◽  
pp. 1038-1040 ◽  
Author(s):  
Paul Froom ◽  
Ester Aghai ◽  
Amalia Kinarty ◽  
Nitza Lahat
Keyword(s):  
Natural Killer ◽  
Myeloproliferative Disorders ◽  
Nk Activity

Central interferon-alpha inhibits natural killer cytotoxicity through sympathetic innervation

1993 ◽  
Vol 265 (2) ◽  
pp. R453-R459 ◽  
Author(s):  
S. Take ◽  
T. Mori ◽  
T. Katafuchi ◽  
T. Hori
Keyword(s):  
Natural Killer ◽  
Interferon Alpha ◽  
Viral Infections ◽  
Sympathetic Innervation ◽  
Nk Activity ◽  
Ifn Alpha ◽  
Nk Cytotoxicity ◽  
The Brain ◽  
Natural Killer Cytotoxicity ◽  
Crf System

The brain has been known to produce high levels of interferon-alpha (IFN-alpha) during viral infections. We investigated the central and peripheral mechanisms of the brain IFN-alpha-induced suppression of natural killer (NK) cytotoxicity in the rat. The activity of NK cells in the spleen and the peripheral blood decreased 30-120 min after intracerebroventricular (icv) injection of recombinant human IFN-alpha of > 1,000 U but not after its intraperitoneal injection. This effect was antagonized by pretreatment with icv naltrexone (NLTX). Splenic denervation was observed to completely abolish the IFN-alpha-induced suppression of NK activity, whereas bilateral adrenalectomy did not. Furthermore, this immunosuppression was blocked by an icv injection of an antagonist of corticotropin-releasing factor (CRF), alpha-helical CRF-(9-41). The icv injection of CRF resulted in reduced NK activity, which was not affected by NLTX. The results suggest that brain IFN-alpha activates the CRF system through central opioid receptors and thereby suppresses the NK cytotoxicity predominantly through splenic sympathetic innervation.

scholarly journals Diminished helper/suppressor lymphocyte ratios and natural killer activity in recipients of repeated blood transfusions

Blood ◽  
1984 ◽  
Vol 64 (1) ◽  
pp. 308-310 ◽  
Author(s):  
J Kaplan ◽  
S Sarnaik ◽  
J Gitlin ◽  
J Lusher
Keyword(s):  
Natural Killer ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Natural Killer Activity ◽  
Clotting Factor ◽  
Nk Activity ◽  
Killer Activity ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Clotting Factor Concentrates

Abstract Immunologic abnormalities qualitatively similar to those seen in acquired immunodeficiency syndrome (AIDS), including a low helper/suppressor lymphocyte ratio and low natural killer (NK) activity, have been observed in many hemophiliacs receiving clotting factor concentrates. To determine whether these changes also occur after repeated blood transfusion, we measured helper/suppressor (T4/T8) ratios and NK activity in four groups of test subjects: (A) 30 subjects with sickle cell anemia (SCA) receiving monthly transfusions, (B) 30 nontransfused sickle cell anemia subjects, (C) 87 individuals with hemophilia or severe von Willebrand's disease, and (D) 30 normal controls. Like the hemophiliacs, transfused SCA subjects had low T4/T8 ratios and low NK activity compared to controls. Nontransfused SCA subjects had normal values. These findings suggest that a modest decrease in T4/T8 ratio and NK activity may be part of the normal immune response to repeated transfusion.

scholarly journals Activated invariant natural killer T cells directly recognize leukemia cells in a CD1d‐independent manner

2020 ◽  
Vol 111 (7) ◽  
pp. 2223-2233
Author(s):  
Takahiro Aoki ◽  
Mariko Takami ◽  
Tomozumi Takatani ◽  
Kiwamu Motoyoshi ◽  
Ayana Ishii ◽  
...  
Keyword(s):  
T Cells ◽  
Natural Killer ◽  
Natural Killer T Cells ◽  
Leukemia Cells ◽  
Independent Manner ◽  
Killer T Cells ◽  
Invariant Natural Killer ◽  
Natural Killer T

scholarly journals Natural killer-mediated lysis of normal and malignant target cells, and its regulation by monocytes.

1985 ◽  
Vol 162 (2) ◽  
pp. 472-486 ◽  
Author(s):  
K Oshimi ◽  
Y Oshimi ◽  
M Satake ◽  
H Mizoguchi
Keyword(s):  
Nk Cells ◽  
Natural Killer ◽  
B Lymphocytes ◽  
Leukemia Cells ◽  
Target Cells ◽  
Large Granular Lymphocytes ◽  
Percoll Density Gradient ◽  
Granular Lymphocytes ◽  
Density Gradient Sedimentation

After depletion of monocytes, natural killer (NK) cells were partially purified from peripheral blood by Percoll density gradient sedimentation. The NK cells were then cultured for 1 d and assayed for their cytotoxicity against various types of normal and malignant target cells. All types of target cells tested were found to be susceptible to NK cells. The susceptible targets were autologous T and B lymphocytes, mitogen-induced T and B blasts, monocytes, large granular lymphocytes, autologous or allogeneic lymphoma and leukemia cells isolated from patients, and cultured cell lines, including those resistant to interferon-activated lymphocytes. Such a broad spectrum of cytotoxicity was demonstrated in 1 d of culture, and freshly prepared NK cells were not cytotoxic, or, if anything, were less cytotoxic. Monocytes and their supernatants, added throughout the course of culture, markedly inhibited the development of their cytotoxicity. These results may suggest that, although NK cells having ability to lyse autologous normal and malignant target cells are present in vivo, their lytic activity is regulated by coexisting monocytes.

Ammonium and α-mannosidase are key factors determining natural killer (NK) activity in patients with liver cirrhosis

1990 ◽  
pp. 588-589
Author(s):  
T Morizane ◽  
S Matsumoto ◽  
H Saito ◽  
T Kagawa ◽  
N Iwabuchi ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Natural Killer ◽  
Nk Activity ◽  
Key Factors

scholarly journals Macrophages protect mycoplasma‐infected chronic myeloid leukemia cells from natural killer cell killing

2020 ◽  
Vol 98 (2) ◽  
pp. 138-151 ◽  
Author(s):  
Qing Wei Winnie Choo ◽  
Ricky Abdi Gunawan Koean ◽  
Shu‐Chun Chang ◽  
Wee Joo Chng ◽  
Ming Chun Chan ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Myeloid Leukemia ◽  
Killer Cell ◽  
Cell Killing ◽  
Leukemia Cells
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