Effect of long-term inhibition of hydroxy-methylglutaryl coenzyme A reductase by mevinolin on the zona fasciculata of rat adrenal cortex

1987 ◽  
Vol 54 (1) ◽  
pp. 67-72 ◽  
Author(s):  
Piera Rebuffat ◽  
Giuseppina Mazzocchi ◽  
Gastone G. Nussdorfer
Keyword(s):  
Adrenal Cortex ◽  
Coenzyme A ◽  
Zona Fasciculata ◽  
Coenzyme A Reductase

3-Hydroxy-3-methylglutaryl coenzyme A reductase activity in beef adrenal cortex

1978 ◽  
Vol 56 (10) ◽  
pp. 958-962 ◽  
Author(s):  
B. Preiss ◽  
L. Tan ◽  
J.-G. Lehoux
Keyword(s):  
Adrenal Cortex ◽  
Sucrose Gradient ◽  
Microsomal Fraction ◽  
Coenzyme A ◽  
Reductase Activity ◽  
Zona Glomerulosa ◽  
Zona Fasciculata ◽  
Hmg Coa Reductase ◽  
Coa Reductase ◽  
Coenzyme A Reductase

3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) activity (mevalonate:NADP+ oxidoreductase (CoA-acylating) EC 1.1.1.34) was demonstrated in beef adrenal cortex. Most of the HMG-CoA reductase activity is in the microsomal fraction while a small percentage of the activity is associated with the mitochondria, Mitochondria purified on a linear sucrose gradient are enriched in HMG-CoA reductase and cytochrome c oxidase activities. The reductase present in microsomal preparations from the whole adrenal cortex has an apparent Km of 5.6 × 10−5 M for (R,S)-HMG-CoA. Reductase activities found in the microsomal fractions from the zona glomerulosa, the zona fasciculata, and the zona reticularis were 1.32, 7.37, and 9.74 nmol mevalonate formed per milligram protein in 30 min respectively.

Short- and long-term regulation of 3-hydroxy 3-methylglutaryl coenzyme A reductase by a 4-methylcoumarin

Biochimie ◽  
2011 ◽  
Vol 93 (7) ◽  
pp. 1165-1171 ◽  
Author(s):  
Laura Trapani ◽  
Marco Segatto ◽  
Veronica Simeoni ◽  
Valentina Balducci ◽  
Ashish Dhawan ◽  
...  
Keyword(s):  
Coenzyme A ◽  
Short And Long Term ◽  
Coenzyme A Reductase

Characterization of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Human Adrenal Cortex*

Endocrinology ◽  
1985 ◽  
Vol 117 (4) ◽  
pp. 1462-1468 ◽  
Author(s):  
JEAN-GUY LEHOUX ◽  
NICOLAS KANDALAFT ◽  
SERGE BELISLE ◽  
DIEGO BELLABARBA
Keyword(s):  
Adrenal Cortex ◽  
Coenzyme A ◽  
Coenzyme A Reductase

ÜBER DEN EINFLUSS VON OESTRADIOL AUF DIE RESTITUTIONSPHASE DER NEBENNIERENRINDE NACH LANGFRISTIGER CORTISONVORBEHANDLUNG

1962 ◽  
Vol 40 (3) ◽  
pp. 410-420 ◽  
Author(s):  
M. Herrmann ◽  
G. Winkler
Keyword(s):  
Adrenal Cortex ◽  
Guinea Pigs ◽  
Diphtheria Toxin ◽  
Zona Fasciculata ◽  
Tissue Lesion ◽  
Haemorrhagic Necrosis

ABSTRACT Male guinea pigs were simultaneously treated with cortisone and oestradiol-dipropionate. Observations were made on the nuclear volumes of the cells of the zona fasciculata of the adrenal cortex, the urinary 17-hydroxycorticoids and the haemorrhagic necrosis after intoxication with diphtheria-toxin. The comparatively long restitution phase of the adrenals following the long-term pretreatment with cortisone only may be considerably reduced by application of oestradioldipropionate, which is shown by the following results: the nuclear volumes of fasciculata cells of the adrenal cortex stay normal or show higher values after termination of the pretreatment. Haemorrhagic necrosis in the adrenal cortex after intoxication with diphtheria-toxin is observed on the 2nd day after long-term pretreatment with cortisone and oestradioldipropionate. In animals treated with cortisone only this tissue lesion is observed at first on the 8th day after termination of the pretreatment. The excretion of 17-hydroxycorticoids does not correspond with this accelerated reaction of the adrenal cortex.

Long-term trophic action of α-melanocyte-stimulating hormone on the zona glomerulosa of the rat adrenal cortex

1986 ◽  
Vol 112 (3) ◽  
pp. 404-408 ◽  
Author(s):  
Claudia Robba ◽  
Piera Rebuffat ◽  
Giuseppina Mazzocchi ◽  
Gastone G. Nussdorfer
Keyword(s):  
Plasma Level ◽  
Adrenal Cortex ◽  
Zona Glomerulosa ◽  
Zona Fasciculata ◽  
Short Term ◽  
Melanocyte Stimulating Hormone ◽  
Glomerulosa Cells ◽  
Zona Glomerulosa Cells ◽  
Stimulating Hormone

Abstract. The effects of α-melanocyte-stimulating hormone (α-MSH) on the rat adrenal cortex were investigated by coupled morphometric and radioimmunological techniques. Short-term α-MSH administration provoked a significant increase in the aldosterone plasma level along with a notable lipid droplet depletion in zona glomerulosa cells. Long-term α-MSH treatment induced a notable hypertrophy of zona glomerulosa cells and a further rise in the blood concentration of aldosterone. α-MSH did not affect zona fasciculata morphology and corticosterone plasma level. The possibility is discussed that α-MSH may be specifically involved in the control of the growth and steroidogenic capacity of rat adrenal zona glomerulosa.

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