Patterns of cross-resistance in a multidrug-resistant small-cell lung carcinoma cell line

1990 ◽  
Vol 26 (4) ◽  
pp. 250-256 ◽  
Author(s):  
S. P. C. Cole
Keyword(s):  
Cell Line ◽  
Lung Carcinoma ◽  
Carcinoma Cell ◽  
Small Cell Lung Carcinoma ◽  
Multidrug Resistant ◽  
Small Cell ◽  
Cross Resistance ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Lung Carcinoma Cell Line

Adsorption of cisplatin on oxidized graphene nanoribbons for improving the uptake in non-small cell lung carcinoma cell line A549

2021 ◽  
Vol 18 ◽  
Author(s):  
Steffi Augustine ◽  
Bala Prabhakar ◽  
Pravin Shende
Keyword(s):  
Cell Line ◽  
Lung Carcinoma ◽  
Carcinoma Cell ◽  
Graphene Nanoribbons ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Lung Carcinoma Cell Line

Background : Graphene nanoribbons are nanosized strips of graphene with unique physicochemical properties like higher drug loading capacity and affinity for tumor cells. Objective: The principal objective of this research was to develop oxidized graphene nanoribbons (O-GNRs)-a based delivery system for cisplatin against non-small cell lung carcinoma cell line A549 by selective endocytosis. Method: The O-GNRs prepared using various synthetic steps like oxidative unzipping were evaluated for various parameters like morphology, Fourier Transform Infrared (FTIR) study, % adsorption efficacy, Differential scanning colometric (DSC) study, and in-vitro efficacy studies. Results: Graphene nanoribbons with the length of 200-250 nm and width of 20-40 nm were obtained. The FTIR spectrum of drug-loaded O-GNRs exhibited a characteristic peak at 1550 cm-1 (-N-H group) of cisplatin. The DSC indicated the presence of sharp endothermic peaks at 59 ºC (PEG), 254 ºC (-C-NH3) and 308.6 ºC (-C-Pt). The % adsorption efficiency was found to be 74.56 ± 0.798% with in-vitro release in controlled manner (63.36 % ± 0.489 %) for 24 h. Conclusion: The nanoformulation showed an average inhibition of 22.72% at a lower dose of cisplatin (> 25%) by passive targeting cell line A549 by DNA alkylation. In the near future, graphene-based systems will establish potential nanosystems in cancer treatment due to the additive effect of graphene with various therapeutic agents.

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