Apolipoprotein A5 T-1131C variant confers risk for metabolic syndrome

2007 ◽  
Vol 13 (3) ◽  
pp. 243-247 ◽  
Author(s):  
Anita Maász ◽  
Péter Kisfali ◽  
Katalin Horvatovich ◽  
Márion Mohás ◽  
Lajos Markó ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Apolipoprotein A5

scholarly journals Haplotype analysis of the Apolipoprotein A5 gene in Moroccan patients with the metabolic syndrome

2015 ◽  
Vol 14 (1) ◽  
Author(s):  
Maria Ajjemami ◽  
Sanaa Ouatou ◽  
Hicham Charoute ◽  
Malika Fakiri ◽  
Houria Rhaissi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Haplotype Analysis ◽  
Apolipoprotein A5 ◽  
The Metabolic Syndrome ◽  
Moroccan Patients

Association of apolipoprotein A5 gene 1131T/C polymorphism with dyslipidemia and insulin resistance in Egyptian patients with metabolic syndrome

2012 ◽  
Vol 22 (6) ◽  
pp. 1245-1250
Author(s):  
Mona Mohamad Fathy ◽  
Amal Abd-Al Wahab ◽  
Salwa Tabozada ◽  
Maha Ibrahim ◽  
Wael Aref ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Apolipoprotein A5 ◽  
Egyptian Patients

Haplotype analysis of the apolipoprotein A5 gene in patients with the metabolic syndrome

2010 ◽  
Vol 20 (7) ◽  
pp. 505-511 ◽  
Author(s):  
P. Kisfali ◽  
M. Mohás ◽  
A. Maász ◽  
N. Polgár ◽  
F. Hadarits ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Haplotype Analysis ◽  
Apolipoprotein A5 ◽  
The Metabolic Syndrome

scholarly journals Association of Apolipoprotein A5 Gene  −1131T>C Polymorphism with the Risk of Metabolic Syndrome in Korean Subjects

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Kwang Hoon Song ◽  
Seongwon Cha ◽  
Sung-Gon Yu ◽  
Hyunjoo Yu ◽  
Soo A. Oh ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Genetic Model ◽  
Serum Triglyceride ◽  
Control Group ◽  
Total Study Population ◽  
Age And Gender ◽  
Apolipoprotein A5 ◽  
Remarkable Effect ◽  
The Metabolic Syndrome ◽  
And Gender

We assessed the associations between theAPOA5  −1131T>C polymorphism and lipid parameters and other risk factors of the metabolic syndrome in Korean subjects. A total of 2,901 participants from 20 oriental medical hospitals in Korea were enrolled between 2006 and 2011. According to the modified National Cholesterol Education Program Adult Treatment Panel III definitions, subjects were classified into the metabolic syndrome group and control group. TheAPOA5  −1131T>C genotype was significantly associated with serum high-density lipoprotein cholesterol levels (effect = − 1.700 mg/dL,P=6.550-E07) in the total study population after adjustment for differences in age and gender. The association of theAPOA5  −1131T>C genotype with serum log-transformed triglyceride was also significant in an additive genetic model (effect = 0.056 mg/dL,P=2.286E-19). After adjustment for age and gender, we determined that the odds ratio for the occurrence of the metabolic syndrome was 1.322 for C-allele carriers in the additive model (95% CI = [1.165 − 1.501],P=1.48E-05). In the current study, we demonstrated that theAPOA5  −1131T>C polymorphism is associated with the metabolic syndrome because of its remarkable effect on serum triglyceride levels in Korean subjects.

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