Infiltrating ductal carcinoma of the breast, metastatic to axillary lymph nodes harboring primary tuberculous lymphadenitis

2006 ◽  
Vol 12 (3) ◽  
pp. 188-189 ◽  
Author(s):  
Singh Avninder ◽  
Sunita Saxena
Keyword(s):  
Lymph Nodes ◽  
Ductal Carcinoma ◽  
Axillary Lymph Nodes ◽  
Tuberculous Lymphadenitis ◽  
Axillary Lymph ◽  
Carcinoma Of The Breast ◽  
Infiltrating Ductal Carcinoma

scholarly journals Intra-mammary lymph nodes, an overlooked breast cancer prognostic tool?

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Tarek Hashem ◽  
Ahmed Abdelmoez ◽  
Ahmed Mohamed Rozeka ◽  
Hazem Abdelazeem
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Ductal Carcinoma ◽  
Percutaneous Biopsy ◽  
Preoperative Imaging ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Pathological Features ◽  
Breast Cancer Patients ◽  
Surgical Data

Abstract Background Due to the high variability of incidence and prevalence of intra-mammary lymph nodes (IMLNs), they might be overlooked during clinical and radiological examinations. Properly characterizing pathological IMLNs and detecting the factors that might influence their prevalence in different stages of breast cancer might aid in proper therapeutic decision-making and could be of possible prognostic value. Methods Medical records were reviewed for all breast cancer patients treated at the National Cancer Institute of Cairo University between 2013 and 2019. Radiological, pathological, and surgical data were studied. Results Intra-mammary lymph nodes were described in the final pathology reports of 100 patients. Five cases had benign breast lesion. Three cases had phyllodes tumors and two cases had ductal carcinoma in situ (DCIS). All ten cases were excluded. The remaining 90 cases all had invasive breast cancer and were divided into two groups: one group for patients with malignant IMLNs (48) and another for patients with benign IMLNs (42). Pathological features of the malignant IMLN group included larger mean tumor size in pathology (4.7 cm), larger mean size of the IMLN in pathology (1.7 cm), higher incidence of lympho-vascular invasion (65.9%), and higher rate of extracapsular extension in axillary lymph nodes (57.4%). In addition, the pathological N stage was significantly higher in the malignant IMLN group. Conclusion Clinicians frequently overlook intra-mammary lymph nodes. More effort should be performed to detect them during preoperative imaging and during pathological processing of specimens. A suspicious IMLN should undergo a percutaneous biopsy. Malignant IMLNs are associated with advanced pathological features and should be removed during surgery.

scholarly journals Unusual Occurrence of Rare Lipid-Rich Carcinoma and Conventional Invasive Ductal Carcinoma in the One Breast: Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Katarina Machalekova ◽  
Karol Kajo ◽  
Marian Bencat
Keyword(s):  
Lymph Nodes ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Frozen Section ◽  
Histological Grade ◽  
Resection Margins ◽  
Axillary Lymph Nodes ◽  
Positive Staining ◽  
Axillary Lymph ◽  
Palpable Mass

A 56-year-old woman noticed a palpable mass in her left breast during self-examination. Patient was admitted to our hospital and malignant bifocal tumour was diagnosed by ultrasonography, digital mammography, magnetic resonance, and core-cut biopsy. The patient underwent planned conservative surgery (biquadrantectomy) with a sentinel node examination, but after results of the frozen section with positive resection margins and positive sentinel lymph nodes subsequent mastectomy with axillary lymph node dissection were realized. Histology in the resection specimen revealed two isolated and distinct tumours. One of the lesions represented conventional invasive ductal carcinoma of histological grade 3, and the second tumour was evaluated as invasive lipid-rich carcinoma, containing tumour cells with clear and foamy cytoplasm. Lipids in neoplastic cells were detected by Oil Red O staining and ultrastructural examination. Immunohistochemical analysis of both carcinomas was almost identical with negative steroid receptors, positive staining of HER-2, and p53 and with high proliferation activity (Ki-67). Mastectomy specimen contained residual foci of invasive ductal carcinoma and dissected axillary lymph nodes were free of metastasis. Patient underwent first cycles of chemotherapy with paclitaxel and Herceptin together with local radiotherapy and two month after surgery is without any evidence of the disease.

Breast Reconstruction With Postmastectomy Radiation: Choices and Tradeoffs

2017 ◽  
Vol 35 (22) ◽  
pp. 2467-2470 ◽  
Author(s):  
Matthew M. Poppe ◽  
Jayant P. Agarwal
Keyword(s):  
Computed Tomography ◽  
Lymph Nodes ◽  
Ductal Carcinoma ◽  
Treatment Plan ◽  
Multidisciplinary Treatment ◽  
Muscle Flap ◽  
Axillary Node ◽  
Axillary Lymph Nodes ◽  
Autologous Reconstruction ◽  
Axillary Lymph

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice. A 45-year-old premenopausal woman presented with multifocal cancer in the right breast, with lesions at 1:00 and 4:00, the largest measuring approximately 3 cm on exam, and multiple palpable right axillary lymph nodes. A core biopsy confirmed invasive ductal carcinoma, grade 2 of 3, that was estrogen receptor positive, progesterone receptor positive, and HER2 negative. Fine needle aspiration of a right axillary node confirmed metastatic carcinoma. A positron emission tomography (PET)/ computed tomography done before starting chemotherapy demonstrated an absence of metastatic disease with expected avidity in two separate breast masses and multiple conglomerated 1-2 cm level I and II axillary lymph nodes. She received neoadjuvant chemotherapy with doxorubicin plus cyclophosphamide, followed by paclitaxel, and had a complete clinical response with resolution of the breast and axillary masses on exam. A repeat PET/computed tomography demonstrated reduced size of the breast and axillary disease, and no significant residual PET avidity. Her breast surgeon recommended a right mastectomy with axillary node dissection. As part of her multidisciplinary treatment plan, she consulted with two plastic surgeons to discuss reconstruction options. Plastic Surgeon A advised placement of an implant at the time of mastectomy while Surgeon B contrasted the pros and cons of an autologous transverse rectus abdominis muscle flap reconstruction with an implant based reconstruction. Surgeon B believed that autologous reconstruction would yield the best long-term cosmetic outcome. Before making her surgery decision, the patient consulted with a radiation oncologist to discuss the effect radiation may have on her reconstruction outcome.

scholarly journals Male Triple Negative Axillary Accessory Breast Cancer, a Case Report

2021 ◽  
Author(s):  
Chao li ◽  
Biao Qian
Keyword(s):  
Breast Cancer ◽  
Adjuvant Chemotherapy ◽  
Lymph Nodes ◽  
Triple Negative ◽  
Ductal Carcinoma ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Ki 67 ◽  
Breast Invasive Ductal Carcinoma ◽  
Accessory Breast

Abstract Background: Breast cancer is the most common malignancy among women worldwide. In men, cases of breast cancer are few and accounts for less than 1% of all cases of breast cancer. Majority of male breast cancer is hormone receptor-positive. The incidence of male axillary accessory breast cancer derived from axillary accessory breast is very low. Here we report a case of male triple negative axillary accessory breast cancer.Case presentation: We present a case of a male triple negative axillary accessory breast cancer in a 67-year-old man that progressively increased in size through a period of 1 year. We performed right accessory breast resection and right axillary lymph nodes dissection. Postoperative pathological analysis revealed right accessory breast invasive ductal carcinoma with apocrine metaplasia. The tumor size was 3.5 * 3.3cm. In addition, 5 metastatic lymph nodes were seen in 27 axillary lymph nodes. Immunohistochemistry showed ER (-), PR (-), Ki-67 30%, HER2 (2 +), GATA-3 (+), GCDFP-15(+), and AR (+). Fish test obtained a negative result. The patient was treated with adjuvant chemotherapy and radiotherapy.Conclusion: Male triple negative axillary accessory breast cancer is rare. Treatment of male triple negative axillary accessory breast cancer is similar to that of women patients. Most patients undergo surgery and adjuvant chemotherapy.

Diagnosis and Therapy of Carcinoma of the Breast

1967 ◽  
Vol 53 (1) ◽  
pp. 65-79
Author(s):  
Mario Margottini
Keyword(s):  
Early Diagnosis ◽  
Lymph Nodes ◽  
Radical Surgery ◽  
Excisional Biopsy ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Carcinoma Of The Breast ◽  
Clinical Stages ◽  
Internal Mammary ◽  
Self Examination

Although prognosis of carcinoma of the breast in clinical stages I and II is conditioned by many factors, early diagnosis and prompt treatment are at present the most useful means at our disposal to achieve the best results. Early diagnosis, and better still the detection of tumours in a preclinical stage, can be arrived at by breast self-examination, periodic check-up and mammography. The latter is particularly useful in revealing clinically silent lesions. Only excisional biopsy can ascertain the diagnosis which it is important to establish when the intramammary lump, because of its small size, lacks any sign of malignancy. Recent studies of the lymphatic spread of breast carcinoma have demonstrated that the parasternal metastases are not a late manifestation of the disease but rather a frequent finding in cancer in clinical stages I and II. These metastases are correlated, not only to the site of the tumor in the inner quadrants of the mammary gland, but also to the metastatic index of the axillary lymph nodes. A similar correlation exists between the number of axillary nodes involved and the frequency of microscopic supraclavicular metastases. When radical surgery is indicated, it should comprise the excision of the internal mammary lymph nodes, and in case a supraclavicular dissection. Inoperable cases should be treated by radiotherapy and chemotherapy. Recently pre, intra and postoperative chemotherapy is being increasingly carried out in association with the basic radio-surgical therapy, but such treatment can only be of help as an adjuvant of radical surgery, not as a substitute for an incomplete operation.

scholarly journals The Correlation between Fasting Blood Glucose Level with Infiltrated Axillary Limph Node Rate in Infiltrating Ductal Carcinoma of the Breast

2017 ◽  
Vol 1 (6) ◽  
Author(s):  
Thomas Aribowo ◽  
Widyanti Soewoto
Keyword(s):  
Lymph Node ◽  
Blood Glucose ◽  
Ductal Carcinoma ◽  
Fasting Blood Glucose ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Fasting Blood Glucose Level ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Infiltrating Ductal Carcinoma

Cancer cell have been shown to extensively use glucose for proliferation, even at hypoxia environment. The consumption of glucose in a hypoxia environment induced HIF and VEGF, which play a role in cancer cell infiltration process . The objective of study is to determine the relationship between fasting blood glucose levels with the amount of infiltrated axillary lymph node in patients with infiltrating ductal carcinoma. This is an analytic observational study with cross sectional design. The data obtained were tested with chi-square test (α < 0.05). This study was conducted on 24 infiltrating ductal carcinoma patients. The results showed p value of 0.004, indicating there is a significant correlation between fasting blood glucose levels with the amount of infiltrated axillary lymph nodes. The correlation coefficient ( r) value was 0.505; indicating medium level correlation. As conclusion, there is a significant correlation between fasting blood glucose levels with the amount of infiltrated axillary lymph node in patients with infiltrating ductal carcinoma.Keywords: axillary lymph nodes, breast cancer, fasting blood glucose level, infiltrating ductal carcinoma

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