Cell proliferation kinetics in two human tumors grown in athymic nude mice

1977 ◽  
Vol 24 (1) ◽  
Author(s):  
E. K. Rofstad ◽  
T. Brustad ◽  
O. Kaalhus
Keyword(s):  
Cell Proliferation ◽  
Nude Mice ◽  
Human Tumors ◽  
Athymic Nude Mice ◽  
Proliferation Kinetics

scholarly journals Alterations of Mouse Proto-oncogenes in Sarcomas Induced after Transplantation of Human Tumors in Athymic Nude Mice

1990 ◽  
Vol 81 (4) ◽  
pp. 333-339 ◽  
Author(s):  
Yasuhito Yuasa ◽  
Hitoshi Yamazaki ◽  
Kohji Maruo ◽  
Yoshito Ueyama ◽  
Masabumi Shibuya ◽  
...  
Keyword(s):  
Nude Mice ◽  
Human Tumors ◽  
Athymic Nude Mice

Cell Proliferation Kinetics and Growth Rate of the Irradiated Human Tumors

1975 ◽  
pp. 850-858 ◽  
Author(s):  
E.P. Malaise ◽  
N. Chavaudra ◽  
F. Pêne ◽  
J-M. Richard ◽  
M. Tubiana
Keyword(s):  
Growth Rate ◽  
Cell Proliferation ◽  
Human Tumors ◽  
Proliferation Kinetics

Metastasis of human tumors in athymic nude mice

1979 ◽  
Vol 24 (6) ◽  
pp. 733-738 ◽  
Author(s):  
Francis E. Sharkey ◽  
Jørgen Fogh
Keyword(s):  
Nude Mice ◽  
Human Tumors ◽  
Athymic Nude Mice

Growth dependent cell proliferation kinetics of a human malignant melanoma grown in nude mice

1985 ◽  
Vol 110 (1) ◽  
pp. 11-16 ◽  
Author(s):  
P. Dias Wickramanayake ◽  
M. Loeffler ◽  
H. O. Klein ◽  
W. Groth ◽  
H. E. Wichmann
Keyword(s):  
Cell Proliferation ◽  
Malignant Melanoma ◽  
Nude Mice ◽  
Human Malignant Melanoma ◽  
Proliferation Kinetics ◽  
Dependent Cell ◽  
Kinetics Of

Changes in Histological Differentiation of Human Tumors Transplanted to Athymic Nude Mice: A Morphometric Study

Pathobiology ◽  
1985 ◽  
Vol 53 (2) ◽  
pp. 100-106 ◽  
Author(s):  
Francis E. Sharkey ◽  
John H. Spicer ◽  
Jørgen Fogh
Keyword(s):  
Nude Mice ◽  
Human Tumors ◽  
Morphometric Study ◽  
Histological Differentiation ◽  
Athymic Nude Mice

Ultrastructure of NPC/HK1 cells heterotransplanted in athymic nude mice

1982 ◽  
Vol 40 ◽  
pp. 236-237
Author(s):  
E.C. Chew ◽  
C.L. Li ◽  
D.P. Huang ◽  
H.C. Ho ◽  
L.S. Mak ◽  
...  
Keyword(s):  
Cell Line ◽  
Nude Mice ◽  
Biopsy Specimen ◽  
Epithelial Cell Line ◽  
Present Communication ◽  
Recurrent Tumour ◽  
Athymic Nude Mice ◽  
Cell Line Establishment ◽  
Fine Structures ◽  
Well Differentiated

An epithelial cell line, NPC/HK1, has recently been established from a biopsy specimen of a recurrent tumour of the nasopharynx which was histologically diagnosed as a moderately to well differentiated squamous cell carcinoma. A definite decrease in the amount of tonofilaments and desmosomes in the NPC/HK1 cells during the cell line establishment was observed. The present communication reports on the fine structures of the NPC/HK1 cells heterotraneplanted in athymic nude mice.

972: Antisense CK2 Gene Therapy Induces Regression in Human Bladder Cancer Growing in Athymic Nude Mice

2004 ◽  
Vol 171 (4S) ◽  
pp. 257-258
Author(s):  
Joel Slaton ◽  
Daniel Sloper ◽  
Miriam Taylor ◽  
Alan Davis ◽  
Khalil Ahmed
Keyword(s):  
Gene Therapy ◽  
Bladder Cancer ◽  
Nude Mice ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Athymic Nude Mice

Lentiviral-Mediated Beclin-1 Overexpression Inhibits Cell Proliferation and Induces Autophagy of Human Esophageal Carcinoma Eca109 Cell Xenograft in Nude Mice

2020 ◽  
Vol 15 (1) ◽  
pp. 70-77
Author(s):  
Junhe Zhang ◽  
Weihua Dong
Keyword(s):  
Growth Rate ◽  
Cell Proliferation ◽  
Esophageal Carcinoma ◽  
Nude Mice ◽  
Beclin 1 ◽  
Control Group ◽  
Vector Group ◽  
Empty Vector ◽  
Empty Vector Group

Background: Esophageal carcinoma is one of the common malignant tumors in digestive tract. BECLIN-1 is a key gene that regulates autophagy, and its abnormal expression may be related with many human tumors. However, the mechanism of BECLIN-1 in esophageal carcinoma remains unknown. Objective: In this study, we explored the effect of BECLIN-1 overexpression on tumor growth in mice with esophageal carcinoma and its mechanism. Methods: Recombined lentiviral vector containing BECLIN-1 was used to transfect human esophageal carcinoma Eca109 cells and establish stable cell line. qRT-PCR was used to detect BECLIN-1 mRNA level in the transfected Eca109 cells, CCK-8 assay was used to detect cell proliferation. Beclin-1, P62 and LC3-II protein expression levels in Eca109 cells were detected using Western blot analysis. Subcutaneous xenograft nude mice model of human esophageal carcinoma was established, and the tumor growths in Beclin-1 group, control group and empty vector group were monitored. Beclin-1 protein expression in vivo was detected by immunohistochemistry. Results: Beclin-1 mRNA and protein were overexpressed in Eca109 cells. Compared with empty vector group, the growth rate of cells transfected with BECLIN-1 decreased significantly. Compared with the control group and empty vector group, the expression level of P62 protein in beclin-1 group was significantly decreased, while the expression level of LC3-II protein was significantly increased. The tumor growth rate in nude mice of Beclin-1 group was significantly lower than that of the control group and empty vector group, and Beclin-1 protein was mainly expressed in Beclin-1 group in vivo. Conclusion: BECLIN-1 can induce autophagy in esophageal carcinoma Eca109 cells, and it can significantly inhibit the growth of esophageal carcinoma.

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