Ultrastructural changes of human sural nerves in the neuropathy induced by intrauterine methylmercury poisoning (so-called fetal Minamata disease)

1978 ◽  
Vol 27 (1) ◽  
Author(s):  
Tadao Takeuchi ◽  
Komyo Eto ◽  
Shinsaku Oyanag ◽  
Hidetoshi Miyajima
Keyword(s):  
Ultrastructural Changes ◽  
Minamata Disease ◽  
Methylmercury Poisoning ◽  
Sural Nerves

Fetal Minamata Disease: A Human Episode of Congenital Methylmercury Poisoning

2018 ◽  
pp. 399-406
Author(s):  
Alessandra A. Dos Santos ◽  
Louis W. Chang ◽  
Grace Liejun Guo ◽  
Michael Aschner
Keyword(s):  
Minamata Disease ◽  
Methylmercury Poisoning

The pathology of methylmercury poisoning (Minamata disease)

2010 ◽  
pp. no-no ◽  
Author(s):  
Komyo Eto ◽  
Masumi Marumoto ◽  
Motohiro Takeya
Keyword(s):  
Minamata Disease ◽  
Methylmercury Poisoning

Ultrastructural Changes in Rough Endoplasmic Reticulum of Renal Proximal Tubule Cells in Tetraethyllead Poisoning

1980 ◽  
Vol 38 ◽  
pp. 440-441
Author(s):  
P. R. Wade ◽  
L. W. Chang ◽  
V. L. Wade
Keyword(s):  
Endoplasmic Reticulum ◽  
Rough Endoplasmic Reticulum ◽  
Renal Damage ◽  
Ultrastructural Changes ◽  
Pathogenetic Mechanism ◽  
Proximal Tubule Cells ◽  
Toxic Impact ◽  
Methylmercury Poisoning ◽  
Renal Proximal Tubule Cells ◽  
Ultrastructural Findings

Tetraethyllead (TEL), a gasoline antiknock additive, poses an occupational and environmental risk to human health. Renal damage is a prominent finding in human TEL intoxication. Levels of urinary and erythrocyte ALA-D are altered. Histological examination of the renal parenchyma reveals degenerative changes in the proximal tubules. Experimental TEL studies also demonstrate kidney damage in mice, rats, rabbits, and dogs by various investigators. The basic pathogenetic mechanism of TEL poisoning is unknown. However, in view of the disruption of rough endoplasmic reticulum (RER) and protein synthesis which constitutes the pathogenetic mechanism of methylmercury poisoning, alteration of the RER may also underl ie the toxic impact of organolead in the cells. This report presents unique ultrastructural findings of such an investigation.

An Autopsy Case of Minamata Disease (Methylmercury Poisoning)—Pathological Viewpoints of Peripheral Nerves

2002 ◽  
Vol 30 (6) ◽  
pp. 714-722 ◽  
Author(s):  
Komyo Eto ◽  
Hidehiro Tokunaga ◽  
Kazuo Nagashima ◽  
Tadao Takeuchi
Keyword(s):  
Peripheral Nerves ◽  
Autopsy Case ◽  
Minamata Disease ◽  
Methylmercury Poisoning
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