Immunomodulation of human cytomegalovirus infection on interferon system in patients with systemic lupus erythematosus

1991 ◽  
Vol 11 (2) ◽  
pp. 126-127 ◽  
Author(s):  
Zhang Xin ◽  
Xu Hui-tang ◽  
Zhang Chun-ying ◽  
Liu Jian-jun ◽  
Liu Chun-ming ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Human Cytomegalovirus ◽  
Lupus Erythematosus ◽  
Cytomegalovirus Infection ◽  
Systemic Lupus ◽  
Human Cytomegalovirus Infection ◽  
Interferon System

ANALYSIS OF INTERFERON-I SIGNALING ACTIVITY IN CHILDREN WITH SYSTEMIC LUPUS ERYTHEMATOSUS: RESULTS OF A PILOT PROSPECTIVE STUDY

2021 ◽  
Vol 100 (3) ◽  
pp. 77-88
Author(s):  
R.K. Raupov ◽  
◽  
E.N. Suspitsyn ◽  
E.M. Kalashnikova ◽  
R.C. Mulkidzhan ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Age Of Onset ◽  
Negative Relationship ◽  
Clinical Manifestations ◽  
Type I ◽  
Systemic Lupus ◽  
Cold Urticaria ◽  
Pediatric Department ◽  
Interferon System

The interferon system (IFN) is a group of signaling molecules with antiviral, antitumor and antiproliferative effects. The most studied signaling pathway is mediated by IFN type I. Mutations of IFN-I-regulated genes are involved in the pathogenesis of systemic lupus erythematosus (SLE). Interferon index (IFN-I-index) – a quantitative indicator of the level of expression of IFN-Iregulated genes – is used to assess the activity of the interferon system. Objective of the study: to assess the level of the IFN-I index in children with SLE, as well as to compare the clinical and laboratory characteristics of patients with high and normal levels of the IFN-I-index. Materials and methods of research: 40 patients (girls – 83%, boys – 17%) under 18 years of age with SLE diagnosed in accordance to the SLICC 2012 criteria were included in a multicenter prospective open uncontrolled nonrandomized continuous study. The age of the patients was 15,2 (12,5 ; 16,7) years. All of them underwent examination and treatment in the Pediatric department № 3 at the clinic of the St. Petersburg State Pediatric Medical University and in the Pediatric department of the Almazov National Medical Research Center. The IFN-I index was determined by real-time PCR with a quantitative assessment of the expression of 5 genes induced by IFN-α and β. Results: aggravated family history of rheumatic diseases was noted in 8 patients: SLE – in 3 (8%), rheumatoid arthritis – in 3 (8%), cold urticaria – in 2 (5%). The average age of onset of the disease is 12 years. The most common clinical manifestations were lesions of the skin, joints, mucous membranes, central nervous system, kidney and fever. 31 patients (78%) had an increased IFN-I index. All cases of kidney failure were observed only in patients with a high IFN index (36% vs 0%, p=0,036). Patients with increased IFN-I-index had statistically significant increased levels of antinuclear (87% vs 56%, p=0,043) and rheumatoid factors (36% vs 0%, p=0,036), higher ECLAM index values (3,0 vs 1.0, p=0,048), ferritin levels (p=0,0008) and, as a consequence, the need for more intensive immunosuppressive therapy (using rituximab and cyclophosphamide) compared with patients with normal IFN-Iindex. A positive statistically significant correlation of the IFN-I index with male sex (r=0,41, p=0,008), nephritis (r=0,35, p=0,026), livedoid rash (r=0,38, p=0,017 ), Raynaud's phenomenon (r=0,37, p=0,018), high antinuclear factor (r=0,82, p=0,001), rheumatoid factor (r=0,654, p=0,011), antibodies to Sm antigen (r=0,57, p=0,034), as well as a negative relationship with anemia (r=–0,67, p=0,009). Conclusion: IFN-I-index can be considered as a surrogate biomarker of activity and prognosis of SLE. Further research is required to validate its diagnostic role.

scholarly journals Congenital cytomegalovirus infection and maternal systemic lupus erythematosus: A case report

1986 ◽  
Vol 29 (11) ◽  
pp. 1402-1404 ◽  
Author(s):  
Mary M. Jones ◽  
Martin D. Lidsky ◽  
Earl J. Brewer ◽  
Martha D. Yow ◽  
W. Daniel Williamson
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Lupus Erythematosus ◽  
Cytomegalovirus Infection ◽  
Systemic Lupus ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus

A longitudinal study of human cytomegalovirus serology and viruria fails to detect active viral infection in 20 systemic lupus erythematosus patients

Lupus ◽  
2000 ◽  
Vol 9 (2) ◽  
pp. 120-126 ◽  
Author(s):  
Signy Bendiksen ◽  
Marijke Van Ghelue ◽  
Ole Petter Rekvig ◽  
Tore Gutteberg ◽  
Hans-Jacob Haga ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Longitudinal Study ◽  
Viral Infection ◽  
Human Cytomegalovirus ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals Human Cytomegalovirus RNAs Immunoprecipitated by Multiple Systemic Lupus Erythematosus Antisera

1989 ◽  
Vol 70 (9) ◽  
pp. 2383-2396 ◽  
Author(s):  
P. C. W. Lord ◽  
C. B. Rothschild ◽  
R. T. DeRose ◽  
B. A. Kilpatrick
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Human Cytomegalovirus ◽  
Lupus Erythematosus ◽  
Systemic Lupus
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