Preliminary research on the relationship between expression of HBV antigens and liver cell necrosis in the liver tissue of patients with chronic liver diseases

1988 ◽  
Vol 8 (1) ◽  
pp. 24-28 ◽  
Author(s):  
Hu Ke-qin ◽  
Song Pei-hui ◽  
Hao Lian-jie
Keyword(s):  
Liver Cell ◽  
Liver Tissue ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Liver Cell Necrosis ◽  
Cell Necrosis ◽  
Chronic Liver Diseases ◽  
Preliminary Research ◽  
The Relationship

scholarly journals Quantitative Analysis of Aldolase A mRNA in Liver Discriminates between Hepatocellular Carcinoma and Cirrhosis

2000 ◽  
Vol 46 (7) ◽  
pp. 901-906 ◽  
Author(s):  
Giuseppe Castaldo ◽  
Giuseppe Calcagno ◽  
Raffaella Sibillo ◽  
Rosario Cuomo ◽  
Gerardo Nardone ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Quantitative Analysis ◽  
Hepatitis C ◽  
Liver Tissue ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Liver Biopsies ◽  
Aldolase A

Abstract Background: Chronic liver diseases can progress to cirrhosis and to hepatocellular carcinoma. Timely and unequivocal recognition of the neoplastic evolution of cirrhosis is critical. To this aim, we used a noncompetitive reverse transcription-PCR procedure to analyze aldolase A mRNA in liver tissue from patients with chronic liver diseases at different stages. Methods: We studied 12 patients with hepatocellular carcinoma, 19 patients affected by chronic hepatitis C or cirrhosis, and 7 healthy controls. Aldolase A mRNA was reverse-transcribed to cDNA, which was then amplified by PCR. The amplified segments were “read” with a novel dot-blot procedure. A calibrator with the same sequence, synthesized in vitro using a T7 phage promoter, was processed at scalar dilutions in parallel to the target samples to generate a calibration curve and so quantify the target mRNA (detection limit, 0.03 amol; linearity spanning five orders of magnitude). Results: Aldolase A mRNA was ∼10-fold higher in liver biopsies from patients with hepatocellular carcinoma vs patients with chronic hepatitis C or cirrhosis, and healthy individuals. Furthermore, aldolase A mRNA concentrations were 1.2- to 21.3-fold higher in 12 liver biopsies compared with the paired surrounding cirrhotic tissue. Conclusions: The quantitative analysis of liver tissue aldolase A mRNA differentiates between nonneoplastic chronic liver diseases and hepatocellular carcinoma, which suggests that it has diagnostic potential.

scholarly journals Association between Albumin-Bilirubin Grade and Non-Protein Respiratory Quotient in Patients with Chronic Liver Diseases

2019 ◽  
Vol 8 (9) ◽  
pp. 1485 ◽  
Author(s):  
Ryo Takata ◽  
Hiroki Nishikawa ◽  
Hirayuki Enomoto ◽  
Kazunori Yoh ◽  
Yoshinori Iwata ◽  
...  
Keyword(s):  
Respiratory Quotient ◽  
Liver Diseases ◽  
Multivariate Analyses ◽  
Independent Predictor ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Optimal Cutoff ◽  
Optimal Cutoff Point ◽  
Grade 3 ◽  
The Relationship

We sought to elucidate the relationship between albumin-bilirubin (ALBI) grade and non-protein respiratory quotient (npRQ) calculated by indirect calorimetry in chronic liver disease (CLD) patients (n = 601, median age = 63 years). Factors linked to npRQ < 0.85, which is reported to be an optimal cutoff point for the prognosis in liver cirrhosis (LC) patients, were also investigated using univariate and multivariate analyses. The median npRQ for all cases was 0.86. In total, 253 patients (42.1%) had npRQ < 0.85. The proportions of patients with npRQ < 0.85 in LC and non-LC patients were 51.9% (166/320) in LC patients and 31.0% (87/281) in non-LC patients (p < 0.0001). The median npRQ in ALBI grades 1, 2, and 3 for all cases were: 0.89, 0.85, and 0.82 (overall p < 0.0001). The proportions of patients with npRQ < 0.85 were 31.0% (71/229) in ALBI grade 1, 46.34% (152/328) in ALBI grade 2, and 68.18% (30/44) in ALBI grade 3 (overall p < 0.0001). In multivariate analyses of factors linked to npRQ < 0.85, ALBI grade 3 (p = 0.0095, hazard ratio = 3.242, ALBI grade 1 as a reference) was an independent predictor along with prothrombin time (p = 0.0139). In conclusion, ALBI grade can be a useful marker for npRQ in patients with CLDs.

Immunophenotyping of lymphocytes in liver tissue of patients with chronic liver diseases by flow cytometry

Hepatology ◽  
1991 ◽  
Vol 14 (1) ◽  
pp. 121-127 ◽  
Author(s):  
Xiuming Li ◽  
Lennox J. Jeffers ◽  
K. Rajender Reddy ◽  
Maria de Medina ◽  
Marcelo Silva ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Liver Tissue ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases

scholarly journals Hyperasialoglycoproteinemia in patients with chronic liver diseases and/or liver cell carcinoma

1984 ◽  
Vol 87 (6) ◽  
pp. 1217-1221 ◽  
Author(s):  
T. Sawamura ◽  
H. Nakada ◽  
H. Hazama ◽  
Y. Shiozaki ◽  
Y. Sameshima ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Liver Cell ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Liver Cell Carcinoma

scholarly journals Involvement of the cytotoxic/suppressor T-cell subset in liver tissue injury of patients with acute and chronic liver diseases

1983 ◽  
Vol 85 (3) ◽  
pp. 657-662 ◽  
Author(s):  
G.R. Pape ◽  
E.P. Rieber ◽  
J. Eisenburg ◽  
R. Hoffmann ◽  
C.M. Balch ◽  
...  
Keyword(s):  
T Cell ◽  
Liver Tissue ◽  
Liver Diseases ◽  
Tissue Injury ◽  
Cell Subset ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Suppressor T Cell ◽  
T Cell Subset

The relationship between hepatic immunoglobulin production and CD154 expression in chronic liver diseases

2006 ◽  
Vol 26 (2) ◽  
pp. 187-196 ◽  
Author(s):  
Marlyn J. Mayo ◽  
James M. Mosby ◽  
Rohan Jeyarajah ◽  
Burton Combes ◽  
Smina Khilnani ◽  
...  
Keyword(s):  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Immunoglobulin Production ◽  
The Relationship

Ribonuclease activities in liver tissue of patients with chronic liver diseases

1990 ◽  
Vol 191 (1-2) ◽  
pp. 101-103
Author(s):  
H. Tsuji ◽  
K. Murai ◽  
K. Akagi ◽  
M. Fujishima
Keyword(s):  
Liver Tissue ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases

scholarly journals Chronic Kidney Disease – Chronic Liver Disease. An Immunologic Cross-talk

2015 ◽  
Vol 53 (1) ◽  
pp. 3-12
Author(s):  
Gh. Gluhovschi ◽  
Ligia Petrica ◽  
I. Sporea ◽  
Manuela Curescu ◽  
Silvia Velciov ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Immune System ◽  
Liver Disease ◽  
Kidney Disease ◽  
Chronic Liver Disease ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Immune Mechanisms ◽  
The Relationship

Abstract The relationship between the kidney and other organs is notable. The bestknown is the relation with the cardiovascular system. Relationships with other organs are less studied, although their involvement sometimes dominates the clinical picture and the outcome of disease. The paper analyzes the kidney-liver relationship, namely chronic kidney disease and chronic liver disease from an immune viewpoint. The immune system operates as a unitary whole. There is an interdependence between the immune system of the liver, considered a lymphoid organ, and the kidney, whose participation in immune processes is well-known. The most important chronic liver diseases are viral hepatitis B and C. Infection with these viruses can lead to renal involvement, producing mainly glomerular disease. At the same time, secondary glomerulonephritis can cause an unfavorable outcome of the primary disease. The relationship between chronic liver disease and chronic kidney disease during chronic B and C hepatitis occurs via circulating immune complexes or complexes formed in situ. Cell-mediated immunity is also involved. The antiviral treatment of B and C hepatitis is also aimed at secondary glomerular disease. The participation of immune mechanisms raises the question of administering immunomodulating medication, a type of medication that influences viral replication - this is why it is associated with antiviral medication. Other two chronic liver diseases, namely liver cirrhosis, in which the main mechanism is a toxic one, and non-alcoholic steatohepatitis can produce via immune mechanisms glomerular involvement. In its turn, chronic kidney disease in advanced stages causes lipid metabolism disturbances with hypertriglyceridemia, which can influence fatty loading of the liver in the above-mentioned liver diseases. One can speak about a cross-talk between the liver and the kidney, in which immune mechanisms play an important role.

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