Isolation and characterization of a novel mouse erythroid differentiation-denucleation related gene (MEDDF)

1999 ◽  
Vol 44 (15) ◽  
pp. 1375-1379
Author(s):  
Zhengyan Zhang ◽  
Shiguang Liu ◽  
Jingbo Zhang ◽  
Shepu Xue
Keyword(s):  
Erythroid Differentiation ◽  
Related Gene ◽  
Isolation And Characterization

HyAlx, an aristaless-related gene, is involved in tentacle formation in hydra

Development ◽  
2000 ◽  
Vol 127 (22) ◽  
pp. 4743-4752 ◽  
Author(s):  
K.M. Smith ◽  
L. Gee ◽  
H.R. Bode
Keyword(s):  
Expression Patterns ◽  
Reaction Diffusion ◽  
The Body ◽  
Related Gene ◽  
Axial Patterning ◽  
Bud Formation ◽  
Isolation And Characterization ◽  
Reaction Diffusion Model ◽  
Head Regeneration

Developmental gradients are known to play important roles in axial patterning in hydra. Current efforts are directed toward elucidating the molecular basis of these gradients. We report the isolation and characterization of HyAlx, an aristaless-related gene in hydra. The expression patterns of the gene in adult hydra, as well as during bud formation, head regeneration and the formation of ectopic head structures along the body column, indicate the gene plays a role in the specification of tissue for tentacle formation. The use of RNAi provides more direct evidence for this conclusion. The different patterns of HyAlx expression during head regeneration and bud formation also provide support for a recent version of a reaction-diffusion model for axial patterning in hydra.

scholarly journals Isolation and characterization of zebrafish NFE2

2002 ◽  
Vol 11 (2) ◽  
pp. 91-98 ◽  
Author(s):  
Stephen J. Pratt ◽  
Anna Drejer ◽  
Helen Foott ◽  
Bruce Barut ◽  
Alison Brownlie ◽  
...  
Keyword(s):  
Globin Gene ◽  
Erythroid Differentiation ◽  
Lineage Differentiation ◽  
Isolation And Characterization ◽  
Distinct Cell ◽  
Domain Mapping ◽  
Hypersensitive Sites ◽  
Globin Gene Expression ◽  
Chromosomal Synteny

Vertebrate hematopoiesis is regulated by distinct cell-specific transcription factors such as GATA-1 and SCL. Mammalian p45-NFE2 was characterized for its ability to bind the hypersensitive sites of the globin locus control region. NFE2 is a member of a cap’n’collar (CNC) and basic zipper (BZIP) superfamily that regulates gene transcription. It has been implicated in diverse processes such as globin gene expression, oxidative stress, and platelet lineage differentiation. Here, we have isolated the zebrafish ortholog of NFE2. The gene is highly homologous, particularly in the DNA-binding domain. Mapping the zebrafish NFE2 to linkage group 23 establishes a region of chromosomal synteny with human chromosome 12, further suggesting evolutionary conservation. During embryogenesis, the zebrafish gene is expressed specifically in erythroid cells and also in the developing ear. NFE2 expression is lacking in zebrafish mutants that have no hematopoietic cells. An analysis of the sauternes mutant, which carries a mutation in the ALAS-2 gene and thus has defective heme synthesis, demonstrates higher levels of NFE2 expression than normal. This further establishes the block to erythroid differentiation in the sauternes mutant. Our studies demonstrate conservation of the vertebrate genetic program for the erythroid lineage.

scholarly journals Isolation and characterization of calcineurin-related gene, its2+ which encodes (1-3) β-D-glucan synthase in fission yeast

1998 ◽  
Vol 76 ◽  
pp. 271
Author(s):  
Norihiko Wakae ◽  
Hisato Shuntoh ◽  
Reiko Sugiura ◽  
Xu Lin Xiao ◽  
Zhang Ying Jie ◽  
...  
Keyword(s):  
Fission Yeast ◽  
Related Gene ◽  
Glucan Synthase ◽  
Isolation And Characterization

The isolation and characterization of 18 equine microsatellite loci, TKY272–TKY289

2000 ◽  
Vol 31 (2) ◽  
pp. 149-149 ◽  
Author(s):  
T Tozaki ◽  
H Kakoi ◽  
S Mashima ◽  
K Hirota ◽  
T Hasegawa ◽  
...  
Keyword(s):  
Microsatellite Loci ◽  
Isolation And Characterization
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