Effect of bay K 8644, a calcium channel agonist, on dog cardiac muscarinic receptors

1991 ◽  
Vol 14 (3) ◽  
pp. 271-278
Author(s):  
Shin Woong Lee ◽  
Young Joo Park ◽  
Jeung Soo Lee
Keyword(s):  
Calcium Channel ◽  
Muscarinic Receptors ◽  
Bay K 8644 ◽  
Channel Agonist

BAY k 8644, a calcium channel agonist, reverses hypotension in endotoxin-shocked rats

1986 ◽  
Vol 130 (3) ◽  
pp. 169-175 ◽  
Author(s):  
Nadine Ives ◽  
John W. King ◽  
Bart Chernow ◽  
Bryan L. Roth
Keyword(s):  
Calcium Channel ◽  
Bay K 8644 ◽  
Channel Agonist

The effect of the calcium channel agonist, Bay K-8644 on human vascular smooth muscle

1985 ◽  
Vol 113 (3) ◽  
pp. 447-451 ◽  
Author(s):  
Venkat Gopalakrishnan ◽  
Laura E. Park ◽  
Chris R. Triggle
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Calcium Channel ◽  
Bay K 8644 ◽  
Channel Agonist

THE CALCIUM CHANNEL AGONIST BAY K 8644 SELECTIVELY REDUCES ETHANOL INTAKE AND PREFERENCE IN ALCOHOL-PREFERRING AA RATS

1996 ◽  
Vol 7 (Supplement 1) ◽  
pp. 25
Author(s):  
BEUN R DE ◽  
R SCHNEIDER ◽  
A KLEIN ◽  
A LOHMANN ◽  
R SCHREIBER ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Ethanol Intake ◽  
Bay K 8644 ◽  
Channel Agonist

Increased vascular response to calcium channel agonist by Dahl S rat kidney

1988 ◽  
Vol 254 (4) ◽  
pp. F533-F539 ◽  
Author(s):  
T. H. Steele ◽  
L. Challoner-Hue
Keyword(s):  
Calcium Channel ◽  
Salt Intake ◽  
Rat Kidney ◽  
Bay K 8644 ◽  
Vascular Response ◽  
Vascular Responsiveness ◽  
Agonist And Antagonist ◽  
6 Hydroxydopamine ◽  
Renal Vascular ◽  
Channel Agonist

We examined responses to the calcium channel agonist, BAY-K 8644, of isolated perfused kidneys from Dahl salt-sensitive (DS) and -resistant (DR) rats that had been stabilized on high (HI) and low (LO) NaCl intakes. Mean arterial pressures of DS/HI rats exceeded those of the other three groups. BAY-K 8644 significantly increased the renal vascular resistance (RVR) of DS/HI and DS/LO kidneys, by 38 and 12%, respectively, but did not increase RVR of DR/HI or DR/LO kidneys significantly (6 and 2%, respectively). Increases in RVR and decreases in glomerular filtration rate of DS/HI kidneys exceeded those of DR/HI kidneys. Increases in the RVR of DS/LO kidneys exceeded those of DR/LO kidneys. Experiments utilizing the separate calcium channel agonist and antagonist enantiomers of BAY-K 8644 corroborated these findings, but at lower concentrations. “Chemical sympathectomy” with 6-hydroxydopamine increased the reactivity of kidneys from only high-NaCl animals to BAY-K 8644 without regard to Dahl S or R status. In conclusion, the DS kidney vasculature manifests an increase in responsiveness to this calcium channel agonist, independently of antecedent NaCl loading or high blood pressure. However, a high antecedent salt intake or hypertension enhances vascular responsiveness of the DS kidney to BAY-K 8644.

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