Recent developments in vitamin D metabolism and its clinical application for renal disease

1988 ◽  
Vol 55 (4) ◽  
pp. 504-511
Author(s):  
Russell W. Chesney
Keyword(s):  
Vitamin D ◽  
Renal Disease ◽  
Clinical Application ◽  
Vitamin D Metabolism ◽  
Recent Developments

Vitamin D

2005 ◽  
Vol 289 (1) ◽  
pp. F8-F28 ◽  
Author(s):  
Adriana S. Dusso ◽  
Alex J. Brown ◽  
Eduardo Slatopolsky
Keyword(s):  
Vitamin D ◽  
Target Genes ◽  
Endocrine System ◽  
Target Cells ◽  
Vitamin D Metabolism ◽  
Diverse Range ◽  
Hydroxyvitamin D ◽  
Dihydroxyvitamin D ◽  
Single Receptor ◽  
Recent Developments

The vitamin D endocrine system plays an essential role in calcium homeostasis and bone metabolism, but research during the past two decades has revealed a diverse range of biological actions that include induction of cell differentiation, inhibition of cell growth, immunomodulation, and control of other hormonal systems. Vitamin D itself is a prohormone that is metabolically converted to the active metabolite, 1,25-dihydroxyvitamin D [1,25(OH)2D]. This vitamin D hormone activates its cellular receptor (vitamin D receptor or VDR), which alters the transcription rates of target genes responsible for the biological responses. This review focuses on several recent developments that extend our understanding of the complexities of vitamin D metabolism and actions: the final step in the activation of vitamin D, conversion of 25-hydroxyvitamin D to 1,25(OH)2D in renal proximal tubules, is now known to involve facilitated uptake and intracellular delivery of the precursor to 1α-hydroxylase. Emerging evidence using mice lacking the VDR and/or 1α-hydroxylase indicates both 1,25(OH)2D3-dependent and -independent actions of the VDR as well as VDR-dependent and -independent actions of 1,25(OH)2D3. Thus the vitamin D system may involve more than a single receptor and ligand. The presence of 1α-hydroxylase in many target cells indicates autocrine/paracrine functions for 1,25(OH)2D3in the control of cell proliferation and differentiation. This local production of 1,25(OH)2D3is dependent on circulating precursor levels, providing a potential explanation for the association of vitamin D deficiency with various cancers and autoimmune diseases.

Advances in vitamin D metabolism as they pertain to chronic renal disease

1976 ◽  
Vol 29 (11) ◽  
pp. 1283-1299 ◽  
Author(s):  
J W Coburn ◽  
D L Hartenbower ◽  
A S Brickman
Keyword(s):  
Vitamin D ◽  
Renal Disease ◽  
Chronic Renal Disease ◽  
Vitamin D Metabolism

Vitamin D Metabolism in Chronic Renal Disease

1985 ◽  
pp. 139-153
Author(s):  
Jacob Lemann ◽  
Richard W. Gray ◽  
Nancy D. Adams
Keyword(s):  
Vitamin D ◽  
Renal Disease ◽  
Chronic Renal Disease ◽  
Vitamin D Metabolism

Vitamin D Inadequacy

2020 ◽  
Keyword(s):  
Vitamin D ◽  
Differential Diagnosis ◽  
Renal Disease ◽  
Calcium Deficiency ◽  
Vitamin D Metabolism ◽  
Key Points

Key Points Treatment Insufficiency or deficiency: 2,000 to 5,000 IU/d, adjusted for ageIf adherence is an issue: 50,000 IU/wk or onetime dose of 200,000 to 400,000 IUPrevention: 400 to 600 IU/d Differential Diagnosis Phosphate or calcium deficiency, disorders of vitamin D metabolism, renal disease Epidemiology Increasing incidence of vitamin D inadequacy

Association of Vitamin D Status With Liver and Kidney Disease: A Systematic Review of Clinical Trials, and Cross-Sectional and Cohort Studies

2019 ◽  
pp. 1-13 ◽  
Author(s):  
Seyed Mostafa Parizadeh ◽  
Majid Rezayi ◽  
Reza Jafarzadeh-Esfehani ◽  
Amir Avan ◽  
Hamideh Ghazizadeh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Kidney Disease ◽  
Renal Disease ◽  
Cohort Studies ◽  
Cochrane Library ◽  
Major Public Health Problem ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Beneficial Effects ◽  
Vitamin D Levels

Abstract. Background: Vitamin D deficiency (VDD) is a major public health problem. There are few comprehensive systematic reviews about the relationship between Vitamin D status and liver and renal disease in Iran. Methods: We systemically searched the following databases: Web of Science; PubMed; Cochrane Library; Scopus; Science Direct; Google Scholar and two Iranian databases (Scientific Information Database (SID) and IranMedex) up until November 2017 to identify all randomized control trials (RCTs), case control, cross-sectional and cohort studies investigating the association between vitamin D and any form of liver or kidney disease. Results: Vitamin D insufficiency, or deficiency (VDD), is highly prevalent in Iran, reports varying between 44.4% in Isfahan to 98% in Gorgan. There is also a high prevalence of VDD among patients with liver or kidney disease, and the administration of vitamin D supplements may have beneficial effects on lipid profile, blood glucose, liver function and fatty liver disease, and bone health. Low serum vitamin D levels are related with abnormalities in these laboratory and clinical parameters. Conclusion: VDD is prevalent in patients with chronic liver or renal disease in Iran. There appear to be several beneficial effects of vitamin D supplementation in vitamin D deficient patients with liver or kidney disease.

Persistent HCV-infection and liver damage change vitamin-D-metabolism

2012 ◽  
Vol 50 (01) ◽  
Author(s):  
A Amanzada ◽  
A Lindhorst ◽  
F Moriconi ◽  
M Blaschke ◽  
T Suermann ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Damage ◽  
Hcv Infection ◽  
Vitamin D Metabolism

Clinical application of vitamin D

2020 ◽  
Vol 3 (2) ◽  
pp. 47-55
Author(s):  
Nam-Seok Joo
Keyword(s):  
Vitamin D ◽  
Clinical Application
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