Effect of intraperitoneal administration of carbohydrates on simulated altitude tolerance in rats

1993 ◽  
Vol 8 (1) ◽  
pp. 20-25
Author(s):  
Ratan Kumar ◽  
D. P. Chattopadhyay ◽  
Radhey Shyam
Keyword(s):  
Intraperitoneal Administration ◽  
Simulated Altitude ◽  
Altitude Tolerance

Species differences in altitude tolerance following X-irradiation

1960 ◽  
Vol 198 (4) ◽  
pp. 762-764 ◽  
Author(s):  
Bernard D. Newsom ◽  
Donald J. Kimeldorf
Keyword(s):  
Food Consumption ◽  
Guinea Pigs ◽  
Species Differences ◽  
Lethal Dose ◽  
Tolerance Test ◽  
Simulated Altitude ◽  
Hypoxic Tolerance ◽  
X Irradiation ◽  
Altitude Tolerance ◽  
The Relationship

The relationship between altitude tolerance and food consumption was investigated in irradiated and nonirradiated animals of several species. Food consumption was measured for 3 days following a mid-lethal dose of x-irradiation to assess the degree of postirradiation anorexia. Seventy-two hours after irradiation those animals, as well as ad libitum-fed and food-deprived nonirradiated animals were exposed to a simulated altitude tolerance test. The mortality produced in 4 hours was used as the criterion of hypoxic tolerance for each species. Irradiated rabbits and rats exhibited a severe decrease in food consumption and an increased hypoxic tolerance. Food consumption of mice was depressed during the 3 days following irradiation although the effect was much less than that observed for rats and rabbits. Guinea pigs and hamsters exhibited only a slight decrease in food consumption with recovery occurring after 24 hours. Mice, guinea pigs and hamsters did not exhibit a significant increase in hypoxic tolerance 3 days after radiation exposure. When nonirradiated rabbits, rats, mice and guinea pigs were food deprived, the hypoxic tolerance was significantly increased in all species.

Effect of restraint on altitude tolerance in the rat

1959 ◽  
Vol 14 (3) ◽  
pp. 395-396 ◽  
Author(s):  
R. G. Bartlett ◽  
P. D. Altland
Keyword(s):  
Oxygen Consumption ◽  
Young Adult ◽  
Emotional Stress ◽  
Simulated Altitude ◽  
Sprague Dawley ◽  
Male And Female ◽  
Experimental Animals ◽  
Sprague Dawley Rats ◽  
Altitude Tolerance ◽  
Colonic Temperature

Young adult male and female Sprague-Dawley rats were exposed to a simulated altitude of 33,500 ft. both with and without restraint. The exposure was begun immediately upon the restraint of the experimental animals. The restrained animals died significantly sooner than did the nonrestrained controls. The possible relation of colonic temperature, oxygen consumption and emotional stress to the decreased altitude tolerance is discussed. It is suggested that the data serve as a warning for caution in the use of restraint for convenience in altitude tolerance experiments. Submitted on August 6, 1958

Thyrodial influence on altitude tolerance.

1964 ◽  
Author(s):  
Domenic A. Debias ◽  
Wang Yen
Keyword(s):  
Altitude Tolerance

Clinical and Scintigraphic Findings in Radiation Myositis Complicating the Intraperitoneal Administration of 198Au

1965 ◽  
Vol 05 (02) ◽  
pp. 188-196
Author(s):  
J. Němec ◽  
J. Kubalt ◽  
S. Vohnout ◽  
J. Schubert ◽  
J. Sudek ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Ascitic Fluid ◽  
Saline Solution ◽  
Intraperitoneal Administration ◽  
Clinical Findings ◽  
Safety Measures ◽  
Muscle Necrosis

SummaryPraeperitoneal administration of colloidal 198Au complicating the treatment of anascitic ovarian cancer is reported. Typical scintiscans and various clinical findings of muscle necrosis and radiation myositis are described. Administration of larger amount of saline solution preceding the radiogold instillation controlled by simultaneous scintiscanning are suggested as safety measures in patients when no ascitic fluid is present.

Experimental Intraperitoneal Administration of Cisplatin-activated Carbon for Rat Ovarian Adenocarcinomas.

1996 ◽  
Vol 43 (1) ◽  
pp. 33-39
Author(s):  
TORU SUGIYAMA ◽  
TAKASHI NISHIDA ◽  
SEISUKE KUMAGAI ◽  
KIMIO USHIJIMA ◽  
ATSUHIKO SHINAGAWA ◽  
...  
Keyword(s):  
Activated Carbon ◽  
Intraperitoneal Administration ◽  
Ovarian Adenocarcinomas

ACUTE TOXICITY OF CERIUM DIOXIDE NANOPARTICLES

2019 ◽  
pp. 56-62
Author(s):  
N. V. Khodykina ◽  
L. P. Tochilkina ◽  
O. N. Novikova ◽  
M. S. Sroslov ◽  
A. Ya. Pocheptsov ◽  
...  
Keyword(s):  
Toxic Effect ◽  
Cerium Dioxide ◽  
Intraperitoneal Administration ◽  
Body Weight Loss ◽  
The Body ◽  
Prooxidant Effect ◽  
High Exposure ◽  
Abdominal Organs ◽  
Metabolic Imbalance ◽  
Hematological Changes

The resorptive effects of 0.01 M cerium nanodioxide sol upon single intraperitoneal administration to rats have been studied. The acute exposure to nanoparticles was found to have a dose-dependent general toxic effect on the body (weight loss, inflammatory changes in the abdominal organs, modification of individual behavior, hematological changes, metabolic imbalance), which develops on the background of POL activation. The prooxidant effect of cerium dioxide nanoparticles is demonstratively manifested at relatively high exposure levels (80–8 mg / kg). The threshold dose for the general toxic effect (Limch integr) is equal to 0.8 mg / kg.

ROLE OF THE STROMAL CELLULAR COMPONENT IN COMPENSATORY PROCESSES IN DIFFUSE LIVER DAMAGE

2018 ◽  
pp. 32-37 ◽  
Author(s):  
Z. A. Shafigullina ◽  
S. Yu. Medvedeva ◽  
I. G. Danilova
Keyword(s):  
Toxic Hepatitis ◽  
Intraperitoneal Administration ◽  
Sharp Decrease ◽  
Cellular Component ◽  
Ki 67 ◽  
Sinusoidal Cells ◽  
Toxic Damage ◽  
Stromal Component ◽  
Regeneration Processes

The aim of the study was to assess the role of the cellular component of the stroma in liver regeneration after its toxic damage. The experimental model of toxic hepatitis caused by intraperitoneal administration of tetrachloromethane (CCl4) showed that regeneration processes in the liver on the 3rd day are manifested in an increase in binuclear hepatocytes, Ki-67 + cells and hepatocytes dividing by mitosis. The reaction of the stromal component is expressed in an increase in the number of CD45 +, mast and sinusoidal cells (SC). On the 7th day of the development of toxic hepatitis the hepatocyte alteration increases, that is accompanied by a sharp decrease in the mitotic index and the number of Ki-67 + cells. In the stromal component there is a decrease in the number of sinusoidal cells, CD45 + and a significant increase in mast cells with a high secretion granule content.

New Poly(3-hydroxybutyrate) Microparticles with Paclitaxel Sustained Release for Intraperitoneal Administration

2017 ◽  
Vol 17 (3) ◽  
pp. 434-441 ◽  
Author(s):  
Anton Bonartsev ◽  
Anton Zernov ◽  
Sergey Yakovlev ◽  
Irina Zharkova ◽  
Vera Myshkina ◽  
...  
Keyword(s):  
Sustained Release ◽  
Intraperitoneal Administration
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