Characterisation and antimicrobial activity studies of the mixed ligand complexes of Cu(II) With 8-hydroxyquinoline and salicylic acids

1984 ◽  
Vol 93 (2) ◽  
pp. 131-138
Author(s):  
Y. Anjaneyulu ◽  
R. Y. Swamy ◽  
R. Prabhakara Rao
Keyword(s):  
Antimicrobial Activity ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Salicylic Acids

scholarly journals Syntheses, Characterization and Biological Activity of Coordination Compounds of Propanedioic Acid and its Mixed Ligand Complexes with N,N'-Dihydroxy-2,3-butanediimine

2021 ◽  
Vol 33 (8) ◽  
pp. 1911-1918
Author(s):  
T.O. Aiyelabola ◽  
E.O. Akinkunmi ◽  
O Osungunna
Keyword(s):  
Antimicrobial Activity ◽  
Metal Ions ◽  
Coordination Compounds ◽  
Mixed Ligand Complex ◽  
Octahedral Geometry ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Planar Geometry ◽  
Acid Complex ◽  
Square Planar

The coordination compounds of propanedioic acid with cobalt(II), nickel(II) and copper(II) ions were synthesized using metal:ligand 1:2. In addition to this, mixed ligand complexes using the same metal ions with propanedioic acid as the primary ligand and N,N'-dihydroxy-2,3-butanediimine as the secondary ligand were also synthesized using M:L1:L2 (1:1:1) where L1 = propanedioic acid, L2 = N,N'-dihydroxy-2,3-butanediimine and M = Cu(II), Ni(II) and Cu(II). The synthesized compounds were characterized using FTIR, UV-vis, magnetic susceptibility measurement and percentage metal composition. The ligand and its metal complexes were tested for their cytotoxic and antibacterial activities. Results indicated that a dimeric square planar geometry was assumed by the cobalt(II) and nickel(II) propanedioic acid complexes. Octahedral geometry was proposed for both cobalt(II) and copper(II) mixed ligand complexes. A dinuclear square pyramidal geometry was suggested for the copper(II) propanedioic acid complex and square planar/octahedral geometry for the nickel(II) mixed ligand complex. The copper(II) propanedioic acid complex elicited the best cytotoxic activity. On the other hand, the nickel(II) propanedioic acid complex showed the remarkable antimicrobial activity. The compounds exhibited good antimicrobial activity in most of the cases with the exception of the cobalt(II) propanedioic acid complex. It was concluded that coordination of the ligands to the metal ions lowered the toxicity of the ligands. It was further concluded that the antimicrobial activity of the compounds was partly dependent on the synergism/additive effect of the intrinsic therapeutic properties of the metal ion and the ligands within the coordination sphere of the complexes synthesized. And this is also in part a function of the geometry assumed by the complexes.

scholarly journals Synthesis, characterisation and antimicrobial activities of mixed ligand complexes of Mn (II), Fe (II) and Co(II) containing N,N'-bis (o-anisaldehyde) p-phenylenediamine (tetradentate schiff base) and gylcine

2018 ◽  
Vol 11 (1) ◽  
pp. 32-36
Author(s):  
I.T. Siraj ◽  
M Sule
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
Mixed Ligand Complex ◽  
Antimicrobial Activities ◽  
Molar Conductance ◽  
Bidentate Ligand ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Ligand Complex ◽  
Tetradentate Schiff Base

Complexes of Mn(II), Fe(II) and Co(II) containing N, N’-bis[o-anisaldehyde]p-phenylenediamine tetradentate Schiff base as primary ligand and glycine as secondary bidentate ligand have been synthesized by reflux in 1:1:1 mole ratio and characterized both analytically and spectroscopically. Molar conductance measurement (69.02 to 86.30Ω–1 cm2 mol–1) of the complexes indicated they are weak electrolyte and magnetic susceptibility measurement shows values in range of 4.53 to 5.59BM indicating their paramagnetism. The infrared data suggested that the Schiff base coordinated via the two nitrogen atoms of the azomethine groups (1628 to 1680 cm-1) and the oxygen atoms of the adjacent methoxy groups (1341 to 1389 cm-1), while glycine coordinated via the nitrogen atom of the amino group (3060-3324 cm-1) and the oxygen atom of the carboxylate anion. Based on the analytical and spectroscopic data the complexes may be assigned an octahedral geometries and molecular formulae of the form [M(L)Gly], where M = Mn, Fe and Co, L=Schiff base and Gly = glycine. The Schiff base and its mixed ligand complexes were screened for antimicrobial activity against Staphylococcus aureus, Escherichia coli, Salmonella typhi, Mucor inducus and Aspergillus fumigatus. The complexes exhibited enhanced antimicrobial activity (10mm to 18mm) at 60 µg/disc as compared to 10mm activity of the uncoordinated Schiff base at the same concentration.Keywords: Mixed ligand complex; Schiff base, Glycine, p-phenylenediamine, o-anisaldehyde

scholarly journals Synthesis, Characterization and Antimicrobial Activity of Mixed Schiff Base Ligand Complexes of Co(II), Ni(II), Cu(II) and Zn(II)

2011 ◽  
Vol 8 (3) ◽  
pp. 1258-1263 ◽  
Author(s):  
A. K. Mapari ◽  
M. S. Hate ◽  
K. V. Mangaonkar
Keyword(s):  
Antimicrobial Activity ◽  
Thermogravimetric Analysis ◽  
Schiff Bases ◽  
Free Ligand ◽  
Antimicrobial Activities ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Azomethine Nitrogen ◽  
Diffusion Method ◽  
Spectral Studies

The mixed ligand complexes of Co(II), Ni(II), Cu(II) and Zn(II) with Schiff basesN-(2-hydroxy-1-naphthylidene)-4-methylaniline (L1H) andN-(2-hydroxybenzylidene)-2,3-dimethylaniline (L2H) have been synthesized and characterized. The resulting complexes were characterized by elemental analysis, thermogravimetric analysis, magnetic moment measurements, conductivity measurements,1H NMR, IR, UV-visible and ESR spectral studies. The Schiff bases acts as bidentate monobasic ligands, coordinating through deprotonated phenolic oxygen and azomethine nitrogen atoms. The complexes are non-electrolytic in DMSO. The presence of the two coordinated water molecules in these complexes was indicated by IR spectra and thermogravimetric analysis of the complexes. From the analytical and spectral data the stoichiometry of these complexes have been found to be [M(L1)(L2)(H2O)2] {where M = Co(II) , Ni(II), Cu(II) and Zn(II)}. It is found that Co(II), Ni(II), Cu(II) and Zn(II) complexes exhibited octahedral geometry. The antimicrobial activities of ligands and their mixed ligand complexes were screened by disc diffusion method. It is found that the metal complexes have higher antimicrobial activity than the free ligand.

scholarly journals Structural elucidation, thermal studies and antimicrobial screening of mixed ligans complexes of 4-benzylimino-2,3-dimethyl-1-phenylpyrazal-5-one and L-Lysine

2021 ◽  
Vol 12 (2) ◽  
pp. 96-103
Author(s):  
E.T. Omotade ◽  
A.P. Oviawe
Keyword(s):  
Thermal Stability ◽  
Antimicrobial Activity ◽  
Thermal Studies ◽  
Octahedral Geometry ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Spectral Studies ◽  
Conductivity Measurements ◽  
Ft Ir ◽  
Bacteria And Fungi

The mixed ligand complexes involving Fe(II), Co(II) and Ni(II) ions, Schiff base 4 phenylpyrazal-5-one (L1) and L-lysine (Lys) were synthesized. The complexes were characterized on the basis of their elemental analysis, conductivity measurements, FT-IR, MS,1H-NMR and 13C-NMR spectral studies. All the synthesized complexes were subjected to simultaneous thermogravimetric analysis to study their decomposition mechanism and thermal stability. The mixed ligand complexes were screened against some strains of bacteria and fungi to study their antimicrobial activity. The complexes were found to be non-electrolytes and possessed octahedral geometry. The results showed that the metal complexes possessed better antimicrobial activity than the free ligands.

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