Tetraethyleneglycol diacrylate (TTEGDA)-crosslinked polystyrene resin as an efficient solid support for gel phase peptide synthesis

1994 ◽  
Vol 106 (5) ◽  
pp. 1123-1138
Author(s):  
M. Renil ◽  
V. N. Rajasekharan Pillai
Keyword(s):  
Peptide Synthesis ◽  
Solid Support ◽  
Crosslinked Polystyrene ◽  
Polystyrene Resin ◽  
Gel Phase

scholarly journals Automated glycan assembly using the Glyconeer 2.1 synthesizer

2017 ◽  
Vol 114 (17) ◽  
pp. E3385-E3389 ◽  
Author(s):  
Heung Sik Hahm ◽  
Mark K. Schlegel ◽  
Mattan Hurevich ◽  
Steffen Eller ◽  
Frank Schuhmacher ◽  
...  
Keyword(s):  
Quality Control ◽  
Peptide Synthesis ◽  
Medical Practice ◽  
Building Blocks ◽  
Solid Support ◽  
Biological Research ◽  
Structure Activity Relationships ◽  
Rapid Access ◽  
Structure Activity ◽  
Control Protocols

Reliable and rapid access to defined biopolymers by automated DNA and peptide synthesis has fundamentally altered biological research and medical practice. Similarly, the procurement of defined glycans is key to establishing structure–activity relationships and thereby progress in the glycosciences. Here, we describe the rapid assembly of oligosaccharides using the commercially available Glyconeer 2.1 automated glycan synthesizer, monosaccharide building blocks, and a linker-functionalized polystyrene solid support. Purification and quality-control protocols for the oligosaccharide products have been standardized. Synthetic glycans prepared in this way are useful reagents as the basis for glycan arrays, diagnostics, and carbohydrate-based vaccines.

scholarly journals Serine promoted synthesis of peptide thioester-precursor on solid support for native chemical ligation

2017 ◽  
Vol 8 (1) ◽  
pp. 117-123 ◽  
Author(s):  
Hader E. Elashal ◽  
Yonnette E. Sim ◽  
Monika Raj
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Solid Support ◽  
Native Chemical Ligation ◽  
Selective Activation ◽  
Chemical Ligation ◽  
Peptide Thioester ◽  
Peptide Thioesters

Fmoc solid phase peptide synthesis of peptide thioesters by displacement of the cyclic urethane moiety obtained by the selective activation of C-terminal serine.

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