Regional profile of polyamines in reversible cerebral ischemia of Mongolian gerbils

1987 ◽  
Vol 7 (2) ◽  
pp. 143-156 ◽  
Author(s):  
W. Paschen ◽  
J. Hallmayer ◽  
G. Mies
Keyword(s):  
Cerebral Ischemia ◽  
Mongolian Gerbils

Effect of policosanol on cerebral ischemia in Mongolian gerbils: Role of prostacyclin and thromboxane A2

1993 ◽  
Vol 49 (3) ◽  
pp. 695-697 ◽  
Author(s):  
M.L. Arruzazabala ◽  
V. Molina ◽  
D. Carbajal ◽  
S Valdés ◽  
R. Más
Keyword(s):  
Cerebral Ischemia ◽  
Thromboxane A2 ◽  
Mongolian Gerbils

scholarly journals Preconditioning with L-alanyl-L-glutamine in a Mongolian Gerbil model of acute cerebral ischemia/reperfusion injury

2011 ◽  
Vol 26 (suppl 1) ◽  
pp. 14-20 ◽  
Author(s):  
Vilma Leite de Sousa Pires ◽  
José Reniclebson Feitosa de Souza ◽  
Sergio Botelho Guimarães ◽  
Antonio Ribeiro da Silva Filho ◽  
José Huygens Parente Garcia ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Femoral Vein ◽  
Control Group ◽  
Mongolian Gerbils ◽  
Cerebral Tissue ◽  
Arterial Blood ◽  
Cerebral Ischemia Reperfusion ◽  
Acute Cerebral Ischemia

PURPOSE: To investigate the effect of L-alanyl-L-glutamine (L-Ala-Gln) preconditioning in an acute cerebral ischemia/reperfusion (I/R) model in gerbils. METHODS: Thirty-six Mongolian gerbils (Meriones unguiculatus), (60-100g), were randomized in 2 groups (n=18) and preconditioned with saline 2.0 ml (Group-S) or 0.75g/Kg of L-Ala-Gln, (Group-G) administered into the femoral vein 30 minutes prior to I/R. Each group was divided into three subgroups (n=6). Anesthetized animals (urethane, 1.5g/Kg, i.p.) were submitted to bilateral occlusion of common carotid arteries during 15 minutes. Samples (brain tissue and arterial blood) were collected at the end of ischemia (T0) and after 30 (T30) and 60 minutes (T60) for glucose, lactate, myeloperoxidase (MPO), thiobarbituric acid reactive substances (TBARS), glutathione (GSH) assays and histopathological evaluation. RESULTS: Glucose and lactate levels were not different in studied groups. However glycemia increased significantly in saline groups at the end of the reperfusion period. TBARS levels were significantly different, comparing treated (Group-G) and control group after 30 minutes of reperfusion (p<0.05) in cerebral tissue. Pretreatment with L-Ala-Gln promoted a significant increase in cerebral GSH contents in Group-G at T30 (p<0.001) time-point compared with Group-S. At T30 and T60, increased levels of GSH occurred in both time-points. There were no group differences regarding MPO levels. Pyknosis, presence of red neurons and intracellular edema were significantly smaller in Group-G. CONCLUSION: Preconditioning with L-Ala-Gln in gerbils submitted to cerebral ischemia/reperfusion reduces oxidative stress and degeneration of the nucleus (pyknosis) and cell death (red neurons) in the cerebral tissue.

Chronic methamphetamine administration inhibits cerebral ischemia-induced hyperactivity in Mongolian gerbils

2001 ◽  
Vol 74 (1-2) ◽  
pp. 127-131 ◽  
Author(s):  
Hiroaki Araki ◽  
Takahiko Yamamoto ◽  
Koujiro Futagami ◽  
Yasuko Karasawa ◽  
Noriko Hino ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Mongolian Gerbils

Polyamine metabolism in reversible cerebral ischemia of Mongolian gerbils

1988 ◽  
Vol 3 (4) ◽  
pp. 297-302 ◽  
Author(s):  
Wulf Paschen ◽  
Gabriele R�hn ◽  
Joachim Hallmayer ◽  
G�nter Mies
Keyword(s):  
Cerebral Ischemia ◽  
Polyamine Metabolism ◽  
Mongolian Gerbils

scholarly journals Capsaicin exhibits neuroprotective effects in a model of transient global cerebral ischemia in Mongolian gerbils

2005 ◽  
Vol 144 (5) ◽  
pp. 727-735 ◽  
Author(s):  
Simona Pegorini ◽  
Daniela Braida ◽  
Chiara Verzoni ◽  
Chiara Guerini-Rocco ◽  
Gian Giacomo Consalez ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Global Cerebral Ischemia ◽  
Mongolian Gerbils ◽  
Neuroprotective Effects ◽  
Transient Global Cerebral Ischemia

scholarly journals Effect of Methamphetamine and Imipramine on Cerebral Ischemia-Induced Hyperactivity in Mongolian Gerbils

2002 ◽  
Vol 88 (3) ◽  
pp. 293-299 ◽  
Author(s):  
Hiroaki Araki ◽  
Takahiko Yamamoto ◽  
Yuri Kobayashi ◽  
Koujiro Futagami ◽  
Hiromu Kawasaki ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Mongolian Gerbils
Sign in / Sign up

Export Citation Format

Share Document