Expression of HO-1 in chronic renal insufficiency rat kidney and implication

2003 ◽  
Vol 23 (3) ◽  
pp. 271-274 ◽  
Author(s):  
Liu Xiaocheng ◽  
Yang Cheng ◽  
He Xiaofeng
Keyword(s):  
Renal Insufficiency ◽  
Chronic Renal Insufficiency ◽  
Rat Kidney

Impairment of Phenylalanine Hydroxylation in Chronic Renal Insufficiency

1973 ◽  
Vol 45 (1) ◽  
pp. 89-97 ◽  
Author(s):  
G. A. Young ◽  
F. M. Parsons
Keyword(s):  
Renal Insufficiency ◽  
Chronic Renal Insufficiency ◽  
Phenylalanine Hydroxylase ◽  
Rat Kidney ◽  
Kidney Tissue ◽  
Amino Nitrogen ◽  
Normal Subjects ◽  
The Individual ◽  
Plasma Tyrosine ◽  
Low Activity

1. Plasma tyrosine and phenylalanine were measured in patients with chronic renal failure and in normal subjects. Plasma tyrosine to phenylalanine ratio was greatly decreased in patients with creatinine clearance less than 16 ml/min, suggesting an impairment of phenylalanine hydroxylation. This ratio correlated with the percentage of essential to total amino nitrogen in the plasma. 2. Phenylalanine hydroxylase from rat liver was inhibited or inactivated (15%) by uraemic plasma but this could not be attributed to the individual effects of urea, creatinine, uric acid, oxalic acid, phenylpyruvic acid, glycine or phosphate. It is unlikely that the degree of inhibition was sufficient to account for the impairment of phenylalanine hydroxylation in chronic renal insufficiency. 3. Phenylalanine hydroxylase was present in rat kidney but at a very low activity relative to that present in liver; consequently, the loss of functional kidney tissue associated with chronic renal insufficiency is unlikely to impair phenylalanine hydroxylation. 4. Plasma tyrosine and liver phenylalanine hydroxylase activity were significantly decreased in partially nephrectomized rats when protein intake was inadequate.

scholarly journals Unfavorable Reduction in the Ratio of Endothelin B to A Receptors in Experimental 5/6 Nephrectomy and Adenine Models of Chronic Renal Insufficiency

2020 ◽  
Vol 21 (3) ◽  
pp. 936
Author(s):  
Suvi Törmänen ◽  
Päivi Lakkisto ◽  
Arttu Eräranta ◽  
Peeter Kööbi ◽  
Ilkka Tikkanen ◽  
...  
Keyword(s):  
Renal Insufficiency ◽  
Chronic Renal Insufficiency ◽  
Rat Kidney ◽  
Kidney Cortex ◽  
Mrna Levels ◽  
Endothelin Receptor ◽  
Protein Ratio ◽  
Protein Levels ◽  
Mrna Ratio ◽  
Endothelin B

Chronic renal insufficiency (CRI) is characterized by increased endothelin 1 (ET-1) synthesis. We studied rat kidney endothelin receptor A (ETA) and receptor B (ETB) expressions after 12 and 27 weeks of 5/6 nephrectomy, and after 12 weeks of 0.3% adenine diet, representing proteinuric and interstitial inflammation models of CRI, respectively. Uric acid and calcium-phosphate metabolism were modulated after 5/6 nephrectomy, while ETA blocker and calcimimetic were given with adenine. Endothelin receptor mRNA levels were measured using RT-qPCR and protein levels using autoradiography (5/6 nephrectomy) or ELISA (adenine model). Both 12 and 27 weeks after 5/6 nephrectomy, kidney cortex ETA protein was increased by ~60% without changes in ETB protein, and the ETB:ETA ratio was reduced. However, the ETB:ETA mRNA ratio did not change. In the adenine model, kidney ETA protein was reduced by ~70%, while ETB protein was suppressed by ~95%, and the ETB:ETA ratio was reduced by ~85%, both at the protein and mRNA levels. The additional interventions did not influence the observed reductions in the ETB:ETA ratio. To conclude, unfavorable reduction in the ETB:ETA protein ratio was observed in two different models of CRI. Therefore, ETA blockade may be beneficial in a range of diseases that cause impaired kidney function.

Hemodialysis Membranes for Acute and Chronic Renal Insufficiency

2013 ◽  
Vol 10 (3) ◽  
pp. 263-268 ◽  
Author(s):  
Jin-Gang Yu ◽  
Lin-Yan Yu ◽  
Xin-Yu Jiang ◽  
Xiao-Qing Chen ◽  
Li-Jian Tao ◽  
...  
Keyword(s):  
Renal Insufficiency ◽  
Chronic Renal Insufficiency
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