Effects of mycophenolate mofetil on renal interstitial fibrosis after unilateral ureteral obstruction in rats

2003 ◽  
Vol 23 (3) ◽  
pp. 269-270 ◽  
Author(s):  
Zhang Chun ◽  
Zhu Zhonghua ◽  
Wang Gang ◽  
Deng Anguo
Keyword(s):  
Mycophenolate Mofetil ◽  
Ureteral Obstruction ◽  
Interstitial Fibrosis ◽  
Unilateral Ureteral Obstruction ◽  
Renal Interstitial Fibrosis

Inhibition of Necroptosis Attenuates Kidney Inflammation and Interstitial Fibrosis Induced By Unilateral Ureteral Obstruction

2017 ◽  
Vol 46 (2) ◽  
pp. 131-138 ◽  
Author(s):  
Xia Xiao ◽  
Chunyang Du ◽  
Zhe Yan ◽  
Yonghong Shi ◽  
Huijun Duan ◽  
...  
Keyword(s):  
Ureteral Obstruction ◽  
Potential Role ◽  
Interstitial Fibrosis ◽  
Kidney Diseases ◽  
Specific Inhibitor ◽  
Unilateral Ureteral Obstruction ◽  
Renal Diseases ◽  
Renal Interstitial Fibrosis ◽  
Renal Inflammation ◽  
Renal Histology

Background: Inflammation plays a crucial role in renal interstitial fibrosis, the pathway of chronic kidney diseases. Necroptosis is a novel form of regulated cell death, which plays a potential role in inflammation and renal diseases. The small molecule necrostatin-1 (Nec-1) is a specific inhibitor of necroptosis. This study was aimed at determining the role of necroptosis, RIP1/RIP3/mixed lineage kinase domain-like (MLKL) signaling pathway, in renal inflammation and interstitial fibrosis related to primitive tubulointerstitial injury. It was also aimed at evaluating the effect of Nec-1 in renal fibrosis induced by unilateral ureteral obstruction (UUO). Methods: Renal histology, immunohistochemistry, western blot, and real-time polymerase chain reaction were performed using UUO C57BL/6J mice model. Moreover, we tested whether Nec-1 was renal-protective in the interstitial fibrosis kidney. Mice were exposed to UUO and injected intraperitoneal with Nec-1 or vehicle. Results: The levels of RIP1/RIP3/MLKL protein and mRNA were increased in the obstructed kidneys 7 days after UUO; this was accompanied by changes in renal pathological lesions. Renal histological examination showed lesser renal damage in Nec-1-treated UUO mice. Renal inflammation, assessed by tumor necrosis factor-α, interleukin-1β, and monocyte chemotactic protein-1 was markedly attenuated by Nec-1. Furthermore, Nec-1 treatment also significantly reduced TGF-β and α-smooth muscle actin, indicating lesser renal interstitial fibrosis. Conclusion: These findings suggest that the participation of necroptosis in UUO is partly demonstrated. And necroptosis inhibition may have a potential role in the treatment of diseases with increased inflammatory response and interstitial fibrosis in renal.

508: Morpidne Modulates Renal Interstitial Fibrosis: A Unilateral Ureteral Obstruction Model

2005 ◽  
Vol 173 (4S) ◽  
pp. 138-138
Author(s):  
Yavor Semerdzhiev ◽  
Pravin Singhal ◽  
Poornima Upadhya ◽  
Beng jit Tan ◽  
Arthur D. Smith ◽  
...  
Keyword(s):  
Ureteral Obstruction ◽  
Interstitial Fibrosis ◽  
Unilateral Ureteral Obstruction ◽  
Renal Interstitial Fibrosis

scholarly journals Factor XA Inhibitor Attenuates Renal Interstitial Fibrosis in Mice With Unilateral Ureteral Obstruction

2017 ◽  
Vol 39 (8) ◽  
pp. e58
Author(s):  
Y. Horinouchi ◽  
Y. Ikeda ◽  
M. Imanishi ◽  
Y. Zamami ◽  
Y. Izawa-Ishizawa ◽  
...  
Keyword(s):  
Ureteral Obstruction ◽  
Interstitial Fibrosis ◽  
Factor Xa ◽  
Unilateral Ureteral Obstruction ◽  
Factor Xa Inhibitor ◽  
Renal Interstitial Fibrosis
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