Immunodeficient mouse models in the characterization of the protective immunity to influenza virus

1998 ◽  
Vol 43 (5) ◽  
pp. 477-478
Author(s):  
A. Bot ◽  
H. Isobe ◽  
C. Bona
Keyword(s):  
Influenza Virus ◽  
Mouse Models ◽  
Protective Immunity ◽  
Immunodeficient Mouse

Immunochemical Characterization of Setaria cervi Microfilarial Antigens Using Novel Antibodies

2019 ◽  
Vol 19 (14) ◽  
pp. 1263-1274 ◽  
Author(s):  
Anuradha Kalani ◽  
Komal Kalani ◽  
Poonam Chaturvedi ◽  
Pankaj Chaturvedi
Keyword(s):  
Adult Worm ◽  
Diagnostic Tests ◽  
Protective Immunity ◽  
Complex Nature ◽  
Immune Recognition ◽  
Setaria Cervi ◽  
Crossed Immunoelectrophoresis ◽  
Study Results ◽  
Immune Rabbit

Background:Filariasis affects millions of people in tropical and subtropical regions of the world and is caused by nematode roundworm. In order to develop a vaccine and specific diagnostic tests, it is important to characterize different stages of the filarial worms. Microfilariae (Mf) stage of the roundworm is found in host’s blood or lymph vessels and can be important not only for developing better immunodiagnostics but also for understanding immune recognition and its relevance to immunepathogenesis and protective immunity.Objective:The present study aimed to immunocharacterize Mf and adult worm antigens that could be helpful in future diagnostic tests.Method:Four different immune sera against Setaria cervi intact live, intact live with adjuvant, intact glutaraldehyde fixed with adjuvant and total somatic Mf were prepared and used for the immunocharacterization of Mf antigens.Results:Our study results suggest that compared to fixed intact Mf, live intact Mf are more immunogenic, as the immune sera generated against intact live Mf showed high ELISA reactivity with Setaria cervi Mf and adult worm antigens. All the four immune sera IgG fractions had surface specificity as determined through considerable ELISA reactivity with S. cervi intact Mf. When tested under native conditions (immunoelectrophoresis and crossed immunoelectrophoresis), all the four immune rabbit sera were able to detect antigens of S. cervi Mf and adult stages.Conclusion:These results can be useful in detailed understanding of the complex nature of the Mf and adult antigens, which are prerequisites in the development of vaccine and more specific diagnostic tests.

scholarly journals Characterization of tumor‐associated macrophages in prostate cancer transgenic mouse models

The Prostate ◽  
2021 ◽  
Author(s):  
Amber E. Groot ◽  
Kayla V. Myers ◽  
Timothy E. G. Krueger ◽  
Ashley L. Kiemen ◽  
Natalia H. Nagy ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Transgenic Mouse ◽  
Mouse Models ◽  
Transgenic Mouse Models ◽  
Tumor Associated Macrophages

Use of zwitterionic detergent for the preparation of an influenza virus vaccine. 1: Preparation and characterization of disrupted virions

Vaccine ◽  
1984 ◽  
Vol 2 (3) ◽  
pp. 193-198 ◽  
Author(s):  
C CRAWFORD ◽  
F MUKHLIS ◽  
R JENNING ◽  
J OXFORD ◽  
D HOCKLEY ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Vaccine ◽  
Influenza Virus Vaccine ◽  
Zwitterionic Detergent

scholarly journals Characterization of Mouse Models of Early Pancreatic Lesions Induced by Alcohol and Chronic Pancreatitis

Pancreas ◽  
2015 ◽  
Vol 44 (6) ◽  
pp. 882-887 ◽  
Author(s):  
Shiping Xu ◽  
Chintan Chheda ◽  
Yassine Ouhaddi ◽  
Hajar Benhaddou ◽  
Mouloud Bourhim ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Mouse Models

Isolation and Characterization of a Novel H9N2 Influenza Virus in Korean Native Chicken Farm

2011 ◽  
Vol 6 (4) ◽  
pp. e68-e69
Author(s):  
Yu-Na Lee ◽  
Dong-Hun Lee ◽  
Jae-Keun Park ◽  
Tea-Hyun Lim ◽  
Ha-Na Youn ◽  
...  
Keyword(s):  
Influenza Virus ◽  
H9n2 Influenza Virus ◽  
Isolation And Characterization ◽  
Native Chicken ◽  
Chicken Farm ◽  
Korean Native Chicken

scholarly journals Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models

2008 ◽  
Vol 95 (3) ◽  
pp. 152-162 ◽  
Author(s):  
Iwan Jones ◽  
Xingxuan He ◽  
Fourogh Katouzian ◽  
Peter I. Darroch ◽  
Edward H. Schuchman
Keyword(s):  
Mouse Models ◽  
Niemann Pick Disease ◽  
Niemann Pick ◽  
Pick Disease
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