Distribution of cells in different stages of the cell cycle and some age-related physiological characteristics in dependence on the dilution rate in chemostat cultures ofCandida utilis

1990 ◽  
Vol 35 (3) ◽  
pp. 245-250 ◽  
Author(s):  
D. Vraná
Keyword(s):  
Cell Cycle ◽  
Dilution Rate ◽  
Physiological Characteristics ◽  
Age Related ◽  
Chemostat Cultures

Compression fractures of the thoracic and lumbar spine in children

1985 ◽  
Vol 66 (6) ◽  
pp. 407-410
Author(s):  
A. A. Rumyantseva ◽  
F. X. Bashirova
Keyword(s):  
Lumbar Spine ◽  
Spinal Fractures ◽  
Physiological Characteristics ◽  
Compression Fractures ◽  
Age Related ◽  
Thoracic And Lumbar Spine ◽  
Fractures In Childhood

The age-related evolution of the spine in combination with the physiological characteristics of a growing organism determines the specificity of the clinical and radiological picture and the treatment of uncomplicated spinal fractures in childhood.

scholarly journals Single-cell RNA-seq reveals a concomitant delay in differentiation and cell cycle of aged hematopoietic stem cells

BMC Biology ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Léonard Hérault ◽  
Mathilde Poplineau ◽  
Adrien Mazuel ◽  
Nadine Platet ◽  
Élisabeth Remy ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Hematopoietic Stem Cells ◽  
Cell Cycle Regulators ◽  
Potential Mechanism ◽  
Rna Seq ◽  
Hematopoietic Stem ◽  
Age Related ◽  
Undifferentiated State ◽  
Reference Map

Abstract Background Hematopoietic stem cells (HSCs) are the guarantor of the proper functioning of hematopoiesis due to their incredible diversity of potential. During aging, heterogeneity of HSCs changes, contributing to the deterioration of the immune system. In this study, we revisited mouse HSC compartment and its transcriptional plasticity during aging at unicellular scale. Results Through the analysis of 15,000 young and aged transcriptomes, we identified 15 groups of HSCs revealing rare and new specific HSC abilities that change with age. The implantation of new trajectories complemented with the analysis of transcription factor activities pointed consecutive states of HSC differentiation that were delayed by aging and explained the bias in differentiation of older HSCs. Moreover, reassigning cell cycle phases for each HSC clearly highlighted an imbalance of the cell cycle regulators of very immature aged HSCs that may contribute to their accumulation in an undifferentiated state. Conclusions Our results establish a new reference map of HSC differentiation in young and aged mice and reveal a potential mechanism that delays the differentiation of aged HSCs and could promote the emergence of age-related hematologic diseases.

scholarly journals Onset of DNA synthesis during the cell cycle in chemostat cultures.

1967 ◽  
Vol 57 (6) ◽  
pp. 1611-1617 ◽  
Author(s):  
H. E. Kubitschek ◽  
H. E. Bendigkeit ◽  
M. R. Loken
Keyword(s):  
Cell Cycle ◽  
Dna Synthesis ◽  
Chemostat Cultures

scholarly journals Perinuclear Lamin A and Nucleoplasmic Lamin B2 Characterize Two Types of Hippocampal Neurons through Alzheimer’s Disease Progression

2020 ◽  
Vol 21 (5) ◽  
pp. 1841
Author(s):  
Laura Gil ◽  
Sandra A. Niño ◽  
Erika Chi-Ahumada ◽  
Ildelfonso Rodríguez-Leyva ◽  
Carmen Guerrero ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Cell Cycle ◽  
Alzheimer's Disease ◽  
Hippocampal Neurons ◽  
Lamin A ◽  
Neuronal Populations ◽  
Cell Cycle Reentry ◽  
Epigenetic Marker ◽  
Age Related ◽  
Elevated Expression

Background. Recent reports point to a nuclear origin of Alzheimer’s disease (AD). Aged postmitotic neurons try to repair their damaged DNA by entering the cell cycle. This aberrant cell cycle re-entry involves chromatin modifications where nuclear Tau and the nuclear lamin are involved. The purpose of this work was to elucidate their participation in the nuclear pathological transformation of neurons at early AD. Methodology. The study was performed in hippocampal paraffin embedded sections of adult, senile, and AD brains at I-VI Braak stages. We analyzed phospho-Tau, lamins A, B1, B2, and C, nucleophosmin (B23) and the epigenetic marker H4K20me3 by immunohistochemistry. Results. Two neuronal populations were found across AD stages, one is characterized by a significant increase of Lamin A expression, reinforced perinuclear Lamin B2, elevated expression of H4K20me3 and nuclear Tau loss, while neurons with nucleoplasmic Lamin B2 constitute a second population. Conclusions. The abnormal cell cycle reentry in early AD implies a fundamental neuronal transformation. This implies the reorganization of the nucleo-cytoskeleton through the expression of the highly regulated Lamin A, heterochromatin repression and building of toxic neuronal tangles. This work demonstrates that nuclear Tau and lamin modifications in hippocampal neurons are crucial events in age-related neurodegeneration.

scholarly journals Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways

Aging Cell ◽  
2016 ◽  
Vol 16 (1) ◽  
pp. 17-26 ◽  
Author(s):  
Lisa A. Lesniewski ◽  
Douglas R. Seals ◽  
Ashley E. Walker ◽  
Grant D. Henson ◽  
Mark W. Blimline ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Vascular Dysfunction ◽  
Nutrient Sensing ◽  
Age Related ◽  
And Oxidative Stress

scholarly journals Increased Re-Entry into Cell Cycle Mitigates Age-Related Neurogenic Decline in the Murine Subventricular Zone

Stem Cells ◽  
2011 ◽  
Vol 29 (12) ◽  
pp. 2005-2017 ◽  
Author(s):  
Elizabeth A. Stoll ◽  
Behnum A. Habibi ◽  
Andrei M. Mikheev ◽  
Jurate Lasiene ◽  
Susan C. Massey ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Subventricular Zone ◽  
Age Related
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