Clinico-pathological significance of the dna histogram patterns in cancer cell nuclei of the stomach and the esophagus

1981 ◽  
Vol 16 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Yasuo Sannohe ◽  
Ryuzo Hiratsuka
Keyword(s):  
Cancer Cell ◽  
Cell Nuclei ◽  
Dna Histogram

scholarly journals An image analysis-based approach for automated counting of cancer cell nuclei in tissue sections

Cytometry ◽  
2003 ◽  
Vol 55A (1) ◽  
pp. 30-42 ◽  
Author(s):  
Constantinos G. Loukas ◽  
George D. Wilson ◽  
Borivoj Vojnovic ◽  
Alf Linney
Keyword(s):  
Image Analysis ◽  
Cancer Cell ◽  
Cell Nuclei ◽  
Tissue Sections

scholarly journals Light-Activated Destruction of Cancer Cell Nuclei by Platinum Diazide Complexes

2006 ◽  
Vol 13 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Patrick J. Bednarski ◽  
Renate Grünert ◽  
Michael Zielzki ◽  
Anja Wellner ◽  
Fiona S. Mackay ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Nuclei

scholarly journals Prognostic Value of the Diversity of Nuclear Chromatin Compartments in Gynaecological Carcinomas

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3838
Author(s):  
Andreas Kleppe ◽  
Fritz Albregtsen ◽  
Jone Trovik ◽  
Gunnar B. Kristensen ◽  
Håvard E. Danielsen
Keyword(s):  
Ovarian Carcinoma ◽  
Endometrial Carcinoma ◽  
Cancer Cell ◽  
Prognostic Value ◽  
Multivariable Analysis ◽  
Risk Groups ◽  
Strongly Correlated ◽  
The Novel ◽  
Cell Nuclei ◽  
Prognostic Information

Statistical texture analysis of cancer cell nuclei stained for DNA has recently been used to develop a pan-cancer prognostic marker of chromatin heterogeneity. In this study, we instead analysed chromatin organisation by automatically quantifying the diversity of chromatin compartments in cancer cell nuclei. The aim was to investigate the prognostic value of such an assessment in relation to chromatin heterogeneity and as a potential supplement to pathological risk classifications in gynaecological carcinomas. The diversity was quantified by calculating the entropy of both chromatin compartment sizes and optical densities within compartments. We analysed a median of 281 nuclei (interquartile range (IQR), 273 to 289) from 246 ovarian carcinoma patients and a median of 997 nuclei (IQR, 502 to 1452) from 791 endometrial carcinoma patients. The prognostic value of the entropies and chromatin heterogeneity was moderately strongly correlated (r ranged from 0.68 to 0.73), but the novel marker was observed to provide additional prognostic information. In multivariable analysis with clinical and pathological markers, the hazard ratio associated with the novel marker was 2.1 (95% CI, 1.3 to 3.5) in ovarian carcinoma and 2.4 (95% CI, 1.5 to 3.9) in endometrial carcinoma. Integration with pathological risk classifications gave three risk groups with distinctly different prognoses. This suggests that the novel marker of diversity of chromatin compartments might possibly contribute to the selection of high-risk stage I ovarian carcinoma patients for adjuvant chemotherapy and low-risk endometrial carcinoma patients for less extensive surgery.

scholarly journals In invasion assays, the breast cancer cell nucleus leads the way

2020 ◽  
Author(s):  
Malte Renz
Keyword(s):  
Cancer Cell ◽  
Cell Nucleus ◽  
Basal Membrane ◽  
Porous Membrane ◽  
Invasion Assay ◽  
Cell Nuclei ◽  
Cell Metastasis ◽  
Live Cell Microscopy ◽  
Shape Changes ◽  
The Way

Abstract Objective Cancer cell metastasis determines disease prognosis. During cancer cell metastasis, the cancer cell and the cancer cell nucleus have to undergo extreme shape changes. To monitor shape changes of cancer cells and cancer cell nuclei and the positioning of the cancer cell nucleus during cancer cell invasion, a customized invasion assay with 8-mm pores and reconstituted basal membrane was imaged using fluorescence live-cell microscopy. Results The observed cells changed their shape from a distinct fibroblast-like spindle shape to an amoeboid shape without polarization immediately after the passage through an 8-mm pore of the invasion assay. During the process of invasion, the cancer cell centered the cancer cell nucleus over the 8-mm pore, and cancer cell nucleus and adjacent cytoplasmic areas moved first through such a pore. Seemingly testing if the largest and least deformable organelle may fit, the cancer cell nucleus led the way through the porous membrane of the invasion assay.

Histological index of cancer malignancy

1927 ◽  
Vol 23 (12) ◽  
pp. 1187-1188
Keyword(s):  
Cancer Cell ◽  
Functional Activity ◽  
Cell Nuclei

For the histological characterization of cancer, the authors put forward 9 factors: 1) specific type of carcinoma, 2) size of cancer cell nuclei, 3) shape of nuclei, 4) clarity of cell borders, 5) functional activity of cells, 6) size of cells, 7) shape of cells, 8) ability of nuclei to stain, and 9) number of mitoses.

Identification of Prostate Cancer Cell Nuclei for DNA-Grading of Malignancy

2012 ◽  
pp. 334-339 ◽  
Author(s):  
David Friedrich ◽  
Chen Jin ◽  
Yu Zhang ◽  
Chen Demin ◽  
Li Yuan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cell Nuclei

Ultrastructural localisation of oestrogen receptor in breast cancer cell nuclei

1990 ◽  
Vol 95 (2) ◽  
pp. 205-207 ◽  
Author(s):  
P. J. Walsh ◽  
J. Teasdale ◽  
P. N. Cowen
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Oestrogen Receptor ◽  
Cell Nuclei
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