Morphochemical changes in brain structures in the course of chronic haloperidol treatment and the correction of these changes with tuftsin

1997 ◽  
Vol 30 (3) ◽  
pp. 213-222 ◽  
Author(s):  
L. M. Gershtein ◽  
M. T. Dobrynina ◽  
A. V. Sergutina
Keyword(s):  
Brain Structures ◽  
Chronic Haloperidol ◽  
Haloperidol Treatment

Movement disorders induced in monkeys by chronic haloperidol treatment

1977 ◽  
Vol 53 (3) ◽  
pp. 289-293 ◽  
Author(s):  
Bernard Weiss ◽  
Shirley Santelli ◽  
George Lusink
Keyword(s):  
Movement Disorders ◽  
Chronic Haloperidol ◽  
Haloperidol Treatment

scholarly journals T193. CHRONIC HALOPERIDOL TREATMENT INDUCES SIGNIFICANT CHANGES IN MICROGLIA AND IN THE EXPRESSION OF THE 18 KDA TRANSLOCATOR PROTEIN TSPO IN NAIVE ADULT RAT BRAINS

2018 ◽  
Vol 44 (suppl_1) ◽  
pp. S191-S191
Author(s):  
Marie Cotel ◽  
Ewelina Lenartowicz ◽  
Sridhar Natesan ◽  
Maria Dadabhoy ◽  
Anthony Vernon
Keyword(s):  
Translocator Protein ◽  
Adult Rat ◽  
Chronic Haloperidol ◽  
Haloperidol Treatment

The Effect of Chronic Haloperidol Treatment on Dendritic Spines in the Rat Striatum

1997 ◽  
Vol 146 (2) ◽  
pp. 471-478 ◽  
Author(s):  
J.J. Kelley ◽  
X.M. Gao ◽  
C.A. Tamminga ◽  
R.C. Roberts
Keyword(s):  
Dendritic Spines ◽  
Rat Striatum ◽  
Chronic Haloperidol ◽  
Haloperidol Treatment

Enhancement of stereotypy induced by nomifensine in rats during continuous chronic haloperidol treatment

1984 ◽  
Vol 50 (1-3) ◽  
pp. 63-65 ◽  
Author(s):  
Nadia M.J. Rupniak ◽  
Peter Jenner ◽  
C.David Marsden
Keyword(s):  
Chronic Haloperidol ◽  
Haloperidol Treatment

Regional homovanillic acid levels and oral movements in rats following chronic haloperidol treatment

1989 ◽  
Vol 98 (3) ◽  
pp. 430-431 ◽  
Author(s):  
Steven A. Kolenik ◽  
Frederick J. Hoffman ◽  
Malcolm B. Bowers
Keyword(s):  
Homovanillic Acid ◽  
Oral Movements ◽  
Chronic Haloperidol ◽  
Haloperidol Treatment

scholarly journals Long-term treatment with haloperidol affects neuropeptide S and NPSR mRNA levels in the rat brain

2015 ◽  
Vol 28 (2) ◽  
pp. 110-116
Author(s):  
Artur Palasz ◽  
Ewa Rojczyk ◽  
Milosz Golyszny ◽  
Lukasz Filipczyk ◽  
John J. Worthington ◽  
...  
Keyword(s):  
Brain Structures ◽  
Term Treatment ◽  
Complex Nature ◽  
Mrna Levels ◽  
Neuropeptide S ◽  
Long Term Treatment ◽  
Rat Brainstem ◽  
Haloperidol Treatment ◽  
Potential Interactions

ObjectiveThe brainstem-derived neuropeptide S (NPS) has a multidirectional regulatory activity, especially as a potent anxiolytic factor. Accumulating data suggests that neuroleptics affect peptidergic signalling in various brain structures. However, there is no information regarding the influence of haloperidol on NPS and NPS receptor (NPSR) expression.MethodsWe assessed NPS and NPSR mRNA levels in brains of rats treated with haloperidol using quantitative real-time polymerase chain reaction.ResultsChronic haloperidol treatment (4 weeks) led to a striking upregulation of NPS and NPSR expression in the rat brainstem. Conversely, the NPSR mRNA expression was decreased in the hippocampus and striatum.ConclusionsThis stark increase of NPS in response to haloperidol treatment supports the hypothesis that this neuropeptide is involved in the dopamine-dependent anxiolytic actions of neuroleptics and possibly also in the pathophysiology of mental disorders. Furthermore, our findings underline the complex nature of potential interactions between dopamine receptors and brain peptidergic pathways, which has potential clinical applications.

Sign in / Sign up

Export Citation Format

Share Document