The possible role of autoimmunity in etiopathogenesis of infantile cirrhosis of liver

1970 ◽  
Vol 37 (7) ◽  
pp. 324-325 ◽  
Author(s):  
S. K. Dikshit ◽  
R. C. Gupta
1940 ◽  
Vol 7 (3) ◽  
pp. 121-134 ◽  
Author(s):  
M. B. Prabhu

1983 ◽  
Vol 50 (1) ◽  
pp. 17-20
Author(s):  
S. C. Vij ◽  
S. D. Bhardwaj ◽  
H. C. Mathur ◽  
M. Raghav

2007 ◽  
Vol 22 (2) ◽  
pp. 136-139 ◽  
Author(s):  
C. Rekha ◽  
Srinivasa Phanidhar ◽  
A. Vidya Sagar ◽  
A. Revathi ◽  
W. A. Asra

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Rushna Firdaus ◽  
Aritra Biswas ◽  
Kallol Saha ◽  
Anirban Mukherjee ◽  
Falguni Pal ◽  
...  

Background. Hepatitis C virus is the major cause of chronic hepatitis worldwide which finally leads to the development of hepatocellular carcinoma. Toll like receptors (TLRs) play an important role in the course of many viral infections, but the role of TLRs in HCV pathogenesis has not been well elucidated so far.Objective. The aim of this study was to analyse the mRNA expression of TLRs 3, 7, and 8 in different stages of HCV infection including chronic, cirrhosis, interferon treated resolved, and relapsed cases.Methodology. Total RNA from whole blood was extracted and mRNA expression of TLRs 3, 7, and 8 genes was analyzed by quantitative real-time RT-PCR usingβ-Actin gene as an internal control.Results. This study consisted of 100 HCV infected individuals and twenty healthy controls. TLR 3 expression was found to be significantly elevated in individuals who had spontaneously cleared the virus(p<0.001), whereas TLR 7 was found to be 3.26 times more elevated in patients with cirrhosis of liver. In IFN induced individuals, TLR 8 expression levels were found to be 2.28-fold elevated as compared to control population.Conclusion. TLRs 3, 7, and 8 are prime biomarker candidates for HCV infection mRNA expression analysis which might improve current therapeutic approaches.


2020 ◽  
Vol 4 (11) ◽  
pp. 27-31
Author(s):  
Mamun Al Mahtab ◽  
Ahmed Lutful Moben ◽  
Md Abdur Rahim ◽  
Md Ashraful Alam ◽  
Faiz Ahmad Khondaker ◽  
...  

2017 ◽  
Vol 4 (2) ◽  
pp. 6-14
Author(s):  
Subash Bhattarai ◽  
M Gyawali ◽  
KR Dewan ◽  
G Shrestha ◽  
BS Patowary ◽  
...  

 Introduction: Upper Gastro-intestinal endoscopy is considered the best screening tool for varices in cirrhotic patients. It is still an expensive, invasive tool, has poor compliance and not routinely available in every hospitals in Nepal. This study was undertaken to establish the role of portal vein diameter and spleen size by ultrasonography in predicting gastro-esophageal varices.Method: One hundred and fifty patients with clinical features, laboratory and sonological findings suggestive of cirrhosis of liver and endoscopic evidence of portal hypertension were included in the study. Ultrasonography assessments of portal vein diameter and spleen size alongside endoscopy for detection of varices were done.Result: Average portal vein diameter of patients without gastro-esophageal varices was 10.800 ± 1.1402 mm, while it was 13.731 ± 1.061mm in patients with varices(p<0.001). Average spleen size of patients without varices was 12.67 ± 2.35 cm and with varices was 15.367 ± 1.210 cm (p < 0.001). There was 92.72 % sensitivity and 90 % specificity for prediction for presence of esophageal varices when the cutoff value for portal vein diameter was 12.25 mm. There was 94.5 % sensitivity and 75 % specificity for prediction for presence of esophageal varices when the cutoff value for spleen size was 13.9 cm.Conclusion: Ultrasonography of portal vein diameter and spleen size is a reliable non invasive tool in predicting the presence of gastro-esophageal varices in patients with liver cirrhosis. With increase in portal vein diameter and spleen size, risk of formation of gastro-esophageal varices also increases and positive correlations exist between them. Nepalese Journal of Radiology, VOL 4 No. 2 ISSUE 7 July-December, 2014: 6-14 


1954 ◽  
Vol 21 (5) ◽  
pp. 230-231
Author(s):  
N. K. Chanda ◽  
Amala Ramcharan

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