Relativistic two-body plus potential problem: Compatible equations and double bound-state solutions (two-fermion case)

1990 ◽  
Vol 103 (5) ◽  
pp. 639-651 ◽  
Author(s):  
J. Bijtebier
Keyword(s):  
Potential Problem ◽  
Bound State

scholarly journals ALGEBRAIC DESCRIPTION OF SHAPE INVARIANCE REVISITED

2017 ◽  
Vol 57 (6) ◽  
pp. 446
Author(s):  
Satoshi Ohya
Keyword(s):  
Morse Potential ◽  
Potential Problem ◽  
Kepler Problem ◽  
Flat Space ◽  
Bound State ◽  
Spherical Space ◽  
Shape Invariance ◽  
One Dimensional ◽  
Nonlinear Algebraic Systems ◽  
Algebraic Description

<span>We revisit the algebraic description of shape invariance method in one-dimensional quantum mechanics. In this note we focus on four particular examples: the Kepler problem in flat space, the Kepler problem in spherical space, the Kepler problem in hyperbolic space, and the Rosen-Morse potential problem. Following the prescription given by Gangopadhyaya et al., we introduce new nonlinear algebraic systems and solve the bound-state problems by means of representation theory.</span>

CRYO-Electron Microscopy of the Acto-Myosin-ATP Complex

1990 ◽  
Vol 48 (1) ◽  
pp. 248-249
Author(s):  
John Trinickt ◽  
Howard White
Keyword(s):  
Electron Microscopy ◽  
Atp Hydrolysis ◽  
Myosin Head ◽  
Bound State ◽  
Cross Linking ◽  
Weakly Bound ◽  
Cryo Electron Microscopy ◽  
Myosin Subfragment 1 ◽  
Attached State ◽  
High Fraction

The primary force of muscle contraction is thought to involve a change in the myosin head whilst attached to actin, the energy coming from ATP hydrolysis. This change in attached state could either be a conformational change in the head or an alteration in the binding angle made with actin. A considerable amount is known about one bound state, the so-called strongly attached state, which occurs in the presence of ADP or in the absence of nucleotide. In this state, which probably corresponds to the last attached state of the force-producing cycle, the angle between the long axis myosin head and the actin filament is roughly 45°. Details of other attached states before and during power production have been difficult to obtain because, even at very high protein concentration, the complex is almost completely dissociated by ATP. Electron micrographs of the complex in the presence of ATP have therefore been obtained only after chemically cross-linking myosin subfragment-1 (S1) to actin filaments to prevent dissociation. But it is unclear then whether the variability in attachment angle observed is due merely to the cross-link acting as a hinge.We have recently found low ionic-strength conditions under which, without resorting to cross-linking, a high fraction of S1 is bound to actin during steady state ATP hydrolysis. The structure of this complex is being studied by cryo-electron microscopy of hydrated specimens. Most advantages of frozen specimens over ambient temperature methods such as negative staining have already been documented. These include improved preservation and fixation rates and the ability to observe protein directly rather than a surrounding stain envelope. In the present experiments, hydrated specimens have the additional benefit that it is feasible to use protein concentrations roughly two orders of magnitude higher than in conventional specimens, thereby reducing dissociation of weakly bound complexes.

Binding Mechanism and Structural Insights into the Identified Protein Target of Covid-19 with In-Vitro Effective Drug Ivermectin

2020 ◽  
Author(s):  
Parth Sarthi Sen Gupta ◽  
Satyaranjan Biswal ◽  
Saroj Kumar Panda ◽  
Abhik Kumar Ray ◽  
Malay Kumar Rana
Keyword(s):  
Ternary Complex ◽  
Bound State ◽  
Molecular Target ◽  
Cooperative Interaction ◽  
Effective Drug ◽  
Rna Dependent Rna Polymerase ◽  
Protein Target ◽  
Ternary Complex Formation ◽  
Structural Insights

<p>While an FDA approved drug Ivermectin was reported to dramatically reduce the cell line of SARS-CoV-2 by ~5000 folds within 48 hours, the precise mechanism of action and the COVID-19 molecular target involved in interaction with this in-vitro effective drug are unknown yet. Among 12 different COVID-19 targets studied here, the RNA dependent RNA polymerase (RdRp) with RNA and Helicase NCB site show the strongest affinity to Ivermectin amounting -10.4 kcal/mol and -9.6 kcal/mol, respectively. Molecular dynamics of corresponding protein-drug complexes reveals that the drug bound state of RdRp with RNA has better structural stability than the Helicase NCB site, with MM/PBSA free energy of -135.2 kJ/mol, almost twice that of Helicase (-76.6 kJ/mol). The selectivity of Ivermectin to RdRp is triggered by a cooperative interaction of RNA-RdRp by ternary complex formation. Identification of the target and its interaction profile with Ivermectin can lead to more powerful drug designs for COVID-19 and experimental exploration. </p>

River-Basin Planning for Control of Nitrate Pollution

1982 ◽  
Vol 14 (4-5) ◽  
pp. 245-252 ◽  
Author(s):  
C S Sinnott ◽  
D G Jamieson
Keyword(s):  
Time Series ◽  
Time Series Analysis ◽  
River Basin ◽  
Water Resource ◽  
Potable Water ◽  
Potential Problem ◽  
Nitrate Pollution ◽  
Optimal Mix ◽  
Regional Basis ◽  
The Impact

The combination of increasing nitrate concentrations in the River Thames and the recent EEC Directive on the acceptable level in potable water is posing a potential problem. In assessing the impact of nitrates on water-resource systems, extensive use has been made of time-series analysis and simulation. These techniques are being used to define the optimal mix of alternatives for overcoming the problem on a regional basis.

Functional characterization and structural modelling of peptidoglycan degrading β-N-acetyl-glucosaminidase from a dental isolate of Serratia marcescens

2020 ◽  
Vol 23 ◽  
Author(s):  
Aditi Rathee ◽  
Anil Panwar ◽  
Seema Kumari ◽  
Sanjay Chhibber ◽  
Ashok Kumar
Keyword(s):  
Functional Characterization ◽  
Major Change ◽  
Crystal Form ◽  
Bound State ◽  
Dynamics Simulation ◽  
Gram Positive ◽  
Structural Cell ◽  
Stability Structure ◽  
Arginine Residues ◽  
The Stability

Introduction:: Enzymatic degradation of peptidoglycan, a structural cell wall component of Gram-positive bacteria, has attracted considerable attention being a specific target for many known antibiotics. Methods:: Peptidoglycan hydrolases are involved in bacterial lysis through peptidoglycan degradation. β-N-acetylglucosaminidase, a peptidoglycan hydrolase, acts on O-glycosidic bonds formed by N-acetylglucosamine and N-acetyl muramic acid residues of peptidoglycan. Aim of present study was to study the action of β-N-acetylglucosaminidase, on methicillin- resistant Staphylococcus aureus (MRSA) and other Gram-negative bacteria. Results:: We investigated its dynamic behaviour using molecular dynamics simulation and observed that serine and alanine residues are involved in catalytic reaction in addition to aspartic acid, histidine, lysine and arginine residues. When simulated in its bound state, the RMSD values were found lesser than crystal form in the time stamp of 1000 picoseconds revealing its stability. Structure remained stably folded over 1000 picoseconds without undergoing any major change further confirming the stability of complex. Conclusion:: It can be concluded that enzymes belonging to this category can serve as a tool in eradicating Gram-positive pathogens and associated infections.

Lower Bound for ppK– Quasi-Bound State Energy

2020 ◽  
Vol 51 (5) ◽  
pp. 979-987 ◽  
Author(s):  
I. Filikhin ◽  
B. Vlahovic
Keyword(s):  
Lower Bound ◽  
State Energy ◽  
Bound State ◽  
Bound State Energy ◽  
Quasi Bound State

Perfect Being Theism and the Great Chain of Being

2017 ◽  
Author(s):  
Yujin Nagasawa
Keyword(s):  
Linear Model ◽  
Potential Problem ◽  
Great Chain Of Being ◽  
Radial Model

This chapter explores exactly what perfect being theism means when it says that God is the being than which no greater is metaphysically possible. It considers the greatness of God in the light of the ‘great chain of being’, a hierarchy of all possible beings. It analyses God’s great-making properties, including knowledge, power, and benevolence, and considers various rigorous models of God’s relations to other possible beings, such as the ‘linear model’ and the ‘radial model’. It defends the radial model but also raises a potential problem it faces. The chapter concludes by arguing that the linear model should be taken seriously as a backup option for perfect being theists.

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