A study of secretory immunoglobulin A on membranous epithelial cells (M cells) and adjacent absorptive cells of rabbit Peyer’s patches

1990 ◽  
Vol 25 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Tomohiro Kato
Keyword(s):  
Epithelial Cells ◽  
Immunoglobulin A ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
M Cells ◽  
Secretory Immunoglobulin A ◽  
Absorptive Cells ◽  
Secretory Immunoglobulin

scholarly journals Fab-Independent Antiadhesion Effects of Secretory Immunoglobulin A on S-Fimbriated Escherichia coli Are Mediated by Sialyloligosaccharides

1998 ◽  
Vol 66 (8) ◽  
pp. 3971-3973 ◽  
Author(s):  
Horst Schroten ◽  
Christoph Stapper ◽  
Ricarda Plogmann ◽  
Henrik Köhler ◽  
Jörg Hacker ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Epithelial Cells ◽  
Human Milk ◽  
Immunoglobulin A ◽  
Secretory Immunoglobulin A ◽  
E Coli ◽  
Human Epithelial Cells ◽  
Early Human ◽  
Secretory Immunoglobulin

ABSTRACT S-fimbriated Escherichia coli strains cause sepsis and meningitis in newborns and are known to recognize the carbohydrate sequence sialyl-(α2-3)-galactoside. We show that adhesion of cloned S-fimbriated E. coli to human epithelial cells is inhibited Fab independently by sialyloligosaccharides on secretory immunoglobulin A (s-IgA). This indicates an anti-infective function of s-IgA (Fc), particularly in early human milk.

Morphometric Evidence Against Lymphocyte-Induced Differentiation of M Cells From Absorptive Cells in Mouse Peyer's Patches

1986 ◽  
Vol 90 (3) ◽  
pp. 609-616 ◽  
Author(s):  
Piotr Siciński ◽  
Jan Rowiński ◽  
Jerzy B. Warchoł ◽  
Wojciech Bem
Keyword(s):  
Peyer's Patches ◽  
Peyer’S Patches ◽  
M Cells ◽  
Induced Differentiation ◽  
Absorptive Cells

scholarly journals Mucin-Related Epitopes Distinguish M Cells and Enterocytes in Rabbit Appendix and Peyer’s Patches

1999 ◽  
Vol 67 (1) ◽  
pp. 357-367 ◽  
Author(s):  
Hugues Lelouard ◽  
Hubert Reggio ◽  
Paul Mangeat ◽  
Marian Neutra ◽  
Philippe Montcourrier
Keyword(s):  
Epithelial Cells ◽  
Plasma Membranes ◽  
Secretory Granules ◽  
Lymphoid Cells ◽  
Peyer's Patches ◽  
Lymphoid Tissues ◽  
Peyer’S Patches ◽  
M Cells ◽  
Apical Membranes ◽  
Rabbit Appendix

ABSTRACT The biochemical composition of the apical membranes of epithelial M cells overlying the gut-associated lymphoid tissues (GALT) is still largely unknown. We have prepared monoclonal antibodies (MAbs) directed against carbonate-washed plasma membranes from epithelial cells detached with EDTA from rabbit appendix, a tissue particularly rich in GALT. As determined by immunofluorescence microscopy, several MAbs specifically recognized either M cells or enterocyte-like cells of the domes from rabbit appendix, sacculus rotundus, and Peyer’s patches. M cells were identified by their large ventral pocket containing lymphoid cells and by specific labeling with antivimentin. Among various characterized MAbs, MAb 104 recognized rabbit immunoglobulins and was used as an apical marker for M cells in the rabbit appendix, MAb 58 selectively stained an integral membrane glycoprotein of greater than 205 kDa located at the apex of M cells, and MAb 214 stained a smaller soluble glycoprotein associated with the apical surfaces from neighboring enterocytes. In addition, both MAbs 58 and 214 also labeled luminal mucus and secretory granules in goblet cells. The selective association of mucin-related molecules at the surfaces of either M cells or enterocyte-like cells of the follicle-associated epithelium suggests that specific carbohydrate antigens are differentially expressed by epithelial cells and could account for the differential binding properties of pathogens.

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