Selenoprotein gene expression during selenium-repletion of selenium-deficient rats

1996 ◽  
Vol 51 (3) ◽  
pp. 211-223 ◽  
Author(s):  
Giovanna Bermano ◽  
Fergus Nicol ◽  
John A. Dyer ◽  
Roger A. Sunde ◽  
Geoffrey J. Beckett ◽  
...  
Keyword(s):  
Gene Expression ◽  
Selenoprotein Gene

scholarly journals Selenoprotein Gene Expression in Thyroid and Pituitary of Young Pigs Is Not Affected by Dietary Selenium Deficiency or Excess

2009 ◽  
Vol 139 (6) ◽  
pp. 1061-1066 ◽  
Author(s):  
Ji-Chang Zhou ◽  
Hua Zhao ◽  
Jun-Gang Li ◽  
Xin-Jie Xia ◽  
Kang-Ning Wang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Selenium Deficiency ◽  
Dietary Selenium ◽  
Selenoprotein Gene ◽  
Young Pigs

scholarly journals The influence of selenium-enriched milk proteins and selenium yeast on plasma selenium levels and rectal selenoprotein gene expression in human subjects

2011 ◽  
Vol 106 (4) ◽  
pp. 572-582 ◽  
Author(s):  
Ying Hu ◽  
Graeme H. McIntosh ◽  
Richard K. Le Leu ◽  
Jane M. Upton ◽  
Richard J. Woodman ◽  
...  
Keyword(s):  
Gene Expression ◽  
Washout Period ◽  
Human Subjects ◽  
Thioredoxin Reductase ◽  
Milk Proteins ◽  
Selenium Yeast ◽  
Plasma Selenium ◽  
Selenoprotein Gene ◽  
Enriched Milk ◽  
Gpx Activity

Certain forms of dietary Se may have advantages for improving human Se status and regulating the risk for disease, such as cancers, including colorectal cancer (CRC). The present study compared the effects of a Se-enriched milk protein (dairy-Se) with a Se-rich yeast (yeast-Se) on plasma Se levels and rectal selenoprotein gene expression since we reasoned that if these genes were not regulated, there was little potential for regulating the risk for CRC in this organ. A total of twenty-three healthy volunteers with plasma Se in the lower half of the population range were supplemented with dairy-Se (150 μg/d) or yeast-Se (150 μg/d) for 6 weeks, followed by 6 weeks of washout period. Blood was sampled every 2 weeks, and rectal biopsies were obtained before and after Se supplementation and after the washout period. Plasma Se levels and glutathione peroxidase (GPx) activity, and rectal mRNA of selenoprotein P (SeP), cytosolic GPx-1 (GPx-1), gastrointestinal GPx-2 (GPx-2) and thioredoxin reductase-1 (TrxR-1) were measured. Plasma Se levels increased rapidly in both Se groups (P < 0·001); plasma GPx activity was not significantly changed. RectalSePmRNA increased at 6 weeks compared with baseline in both Se groups (P < 0·05); only dairy-Se resulted in a sustained elevation ofSePafter the washout period (P < 0·05). RectalGPx-1andGPx-2mRNA were higher with dairy-Se (P < 0·05) than with yeast-Se at 6 weeks. In conclusion, three rectal selenoprotein mRNA were differentially regulated by dairy-Se and yeast-Se. Changes in rectal selenoproteins are not predicted by changes in plasma Se; dairy-Se effectively regulates the expression of several rectal selenoproteins of relevance to the risk for CRC.

scholarly journals Effects of Selenium Supplementation on Selenoprotein Gene Expression and Response to Influenza Vaccine Challenge: A Randomised Controlled Trial

PLoS ONE ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. e14771 ◽  
Author(s):  
Andrew J. Goldson ◽  
Susan J. Fairweather-Tait ◽  
Charlotte N. Armah ◽  
Yongping Bao ◽  
Martin R. Broadley ◽  
...  
Keyword(s):  
Gene Expression ◽  
Randomised Controlled Trial ◽  
Influenza Vaccine ◽  
Controlled Trial ◽  
Selenium Supplementation ◽  
Selenoprotein Gene ◽  
Randomised Controlled

A cell culture model to study regulation of selenoprotein gene expression by selenium

1996 ◽  
Vol 24 (2) ◽  
pp. 224S-224S ◽  
Author(s):  
GIOVANNA BERMANO ◽  
JOHN ARTHUR ◽  
JOHN HESKETH
Keyword(s):  
Gene Expression ◽  
Cell Culture ◽  
Cell Culture Model ◽  
Selenoprotein Gene ◽  
Culture Model ◽  
A Cell

scholarly journals Association of selenoprotein gene expression with pancreatic atrophy in broiler chicks

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Dai-Lin Li ◽  
Jia-Qiang Huang ◽  
Hua Zhao ◽  
Xin-Jie Xia ◽  
Kang- Ning Wang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Broiler Chicks ◽  
Selenoprotein Gene ◽  
Pancreatic Atrophy

Regulation of selenoprotein gene expression and thyroid hormone metabolism

1996 ◽  
Vol 24 (2) ◽  
pp. 384-388 ◽  
Author(s):  
J. R. Arthur ◽  
G. Bermano ◽  
J. H. Mitchell ◽  
J. E. Hesketh
Keyword(s):  
Gene Expression ◽  
Thyroid Hormone ◽  
Hormone Metabolism ◽  
Selenoprotein Gene ◽  
Thyroid Hormone Metabolism
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