Detection of inhibin α and βA subunits (inhibin A, B, activin A,AB) in the human pituitary gland and in pituitary adenomas by immunohistochemistry and nonradioisotopicin situ hybridization

1998 ◽  
Vol 9 (2) ◽  
pp. 125-134 ◽  
Author(s):  
Makoto Sugiyama ◽  
Naoko Sanno ◽  
Akira Teramoto ◽  
R. Yoshiyuki Osamura
2010 ◽  
Vol 58 (10) ◽  
pp. 881-889 ◽  
Author(s):  
Stefano La Rosa ◽  
Davide Vigetti ◽  
Claudia Placidi ◽  
Giovanna Finzi ◽  
Silvia Uccella ◽  
...  

Author(s):  
K. Kovacs ◽  
E. Horvath

Chromophobe pituitary adenomas arise from adenohypophysial cells and fail to exhibit cytoplasmic staining with conventional acid or basic dyes by light microscopy. The aim of the present work was to study the electron microscopic features of these tumors, to separate them into distinct entities and to correlate their fine structural appearances with secretory activity.Among 48 surgically removed various pituitary adenomas 30 tumors were found which, based on the tinctorial characteristics of the cytoplasm, corresponded to chromophobe adenomas. For electron microscopic investigation pieces of these tumors were fixed in 2.5 per cent glutaraldehyde in Sorensen's buffer, post fixed in 1 per cent osmium tetroxide in Millonig's buffer, dehydrated in graded ethanol and embedded in Epon 812. Ultrathin sections were stained with uranyl acetate and lead citrate.By electron microscopy it was possible to separate chromophobe adenomas into 3 distinct entities: 1) adenomas consisting of sparsely granulated growth hormone cells (7 cases).


1983 ◽  
Vol 96 (2) ◽  
pp. 303-309 ◽  
Author(s):  
A. M. McNicol ◽  
H. Thomson ◽  
C. J. R. Stewart

The distribution of specifically stained corticotrophic cells has been studied in the pituitary glands of 11 dogs with pituitary-dependent hyperadrenocorticism. The results suggest that the disease is not a single entity, and that some cases are caused by primary abnormality of the pituitary gland whereas others appear to be the result of dysfunction of the hypothalamus or central nervous system. The patterns correspond closely to those demonstrated in the human pituitary gland in Cushing's disease, and confirm that the canine disease is a useful model for the study of the pathogenesis of the variants of the condition.


1975 ◽  
Vol 379 (1) ◽  
pp. 247-261 ◽  
Author(s):  
Paul Roos ◽  
D.V. Dervartanian ◽  
Gunilla Jacobson ◽  
Leif Wide

1992 ◽  
Vol 56 (5) ◽  
pp. 729-734 ◽  
Author(s):  
Solange C. Hearn ◽  
Philip M. Jones ◽  
Mohammad A. Ghatei ◽  
Johanna Byrne ◽  
Sarah F. Hill ◽  
...  

1985 ◽  
Vol 40 (5) ◽  
pp. 419-422 ◽  
Author(s):  
Errol B. De Souza ◽  
Marilyn H. Perrin ◽  
Peter J. Whitehouse ◽  
Jean Rivier ◽  
Wylie Vale ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document