Clinical course and long-term prognosis of Japanese patients with ulcerative colitis

1991 ◽  
Vol 26 (3) ◽  
pp. 312-318 ◽  
Author(s):  
Nobuo Hiwatashi ◽  
Hideo Yamazaki ◽  
Mitsuo Kimura ◽  
Tomizou Morimoto ◽  
Hikaru Watanabe ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Course ◽  
Japanese Patients ◽  
Long Term Prognosis

scholarly journals Analysis of the Long-Term Prognosis in Japanese Patients with Ulcerative Colitis Treated with New Therapeutic Agents and the Correlation between Prognosis and Disease Susceptibility Loci

2021 ◽  
pp. 1-11
Author(s):  
Kasumi Hishinuma ◽  
Rintaro Moroi ◽  
Daisuke Okamoto ◽  
Yusuke Shimoyama ◽  
Masatake Kuroha ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Multivariate Analysis ◽  
Poor Response ◽  
Japanese Patients ◽  
Therapeutic Agents ◽  
Aminosalicylic Acid ◽  
Kaplan Meier ◽  
Significant Difference ◽  
Long Term Prognosis

<b><i>Background:</i></b> New therapeutic agents, including biologics and small-molecule drugs, are widely used to treat ulcerative colitis (UC). This study evaluates long-term prognosis in Japanese patients treated with these agents and the association between prognosis and genetic susceptibility to UC. <b><i>Methods:</i></b> We evaluated surgery-free rates using the Kaplan-Meier method in the total cohort and in patients treated with prednisolone and new therapeutic agents. Multivariate analysis was performed to identify clinical factors affecting surgical rates using Cox’s proportional hazard model. The rate of use of new therapeutic agents was compared using the Kaplan-Meier method, and multivariate analysis was conducted to investigate the correlation between the single-nucleotide polymorphism (SNP) rs117506082 and long-term prognosis. <b><i>Results:</i></b> Surgery-free survival decreased over time. There was no significant difference in this parameter between patients who were administered prednisolone and those who were administered new therapeutic agents. Poor response to prednisolone and treatment without topical 5-aminosalicylic acid were poor prognostic factors. Shorter time from diagnosis to initiation of treatment with new therapeutic agents was a risk factor for colectomy. The AA genotype of SNP rs117506082 was associated with a shorter time to surgery and increased use of new therapeutic agents. <b><i>Conclusions:</i></b> The use of new therapeutic agents might improve long-term prognosis in patients with more severe UC. Previously identified genetic risk factors were not significantly associated with a higher rate of colectomy.

Tu1983 The Investigation of Medium- to Long-Term Prognosis of Ulcerative Colitis Patients Using Ulcerative Colitis Endoscopic Index of Severity (UCEIS)

2016 ◽  
Vol 150 (4) ◽  
pp. S997
Author(s):  
Mari Arai ◽  
Makoto Naganuma ◽  
Shinya Sugimoto ◽  
Hiroki Kiyohara ◽  
Keiko Ohno ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Index Of Severity ◽  
Long Term Prognosis

Genotype and Long-term Clinical Course of Bietti Crystalline Dystrophy in Korean and Japanese Patients

2021 ◽  
Author(s):  
Yusuke Murakami ◽  
Yoshito Koyanagi ◽  
Masatoshi Fukushima ◽  
Marika Yoshimura ◽  
Kohta Fujiwara ◽  
...  
Keyword(s):  
Clinical Course ◽  
Japanese Patients ◽  
Bietti Crystalline Dystrophy

295 DOES TREATMENT INTENSIFICATION FOR ULCERATIVE COLITIS PATIENTS WITH CLINICAL REMISSION WHO HAVE MILD ENDOSCOPIC ACTIVITY IMPROVE LONG-TERM PROGNOSIS?

2019 ◽  
Vol 89 (6) ◽  
pp. AB70-AB71 ◽  
Author(s):  
Shuhei Hosomi ◽  
Shigehiro Itani ◽  
Rieko Nakata ◽  
Naoko Sugita ◽  
Yu Nishida ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Remission ◽  
Treatment Intensification ◽  
Long Term Prognosis

Clinical course and long-term prognosis of Crohn's disease in Japan

1994 ◽  
Vol 29 (4) ◽  
pp. 406-414 ◽  
Author(s):  
Mitsuo Okada ◽  
Toshihiro Sakurai ◽  
Tsuneyoshi Yao ◽  
Mitsuo Iida ◽  
Nobuo Okabe ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Clinical Course ◽  
Long Term Prognosis

scholarly journals Factors influencing the clinical course and the long-term prognosis of patients with variant angina.

1987 ◽  
Vol 28 (3) ◽  
pp. 293-306 ◽  
Author(s):  
Hiroshi KISHIDA ◽  
Noritake HATA ◽  
Yoshiki KUSAMA ◽  
Takeshi SUZUKI ◽  
Tsutomu SAITO ◽  
...  
Keyword(s):  
Clinical Course ◽  
Variant Angina ◽  
Factors Influencing ◽  
Long Term Prognosis

scholarly journals Long-term prognosis of Japanese patients with biologic-naïve Crohn’s disease treated with anti-tumor necrosis factor-α antibodies

2019 ◽  
Vol 17 (1) ◽  
pp. 94-106 ◽  
Author(s):  
Rintaro Moroi ◽  
Katsuya Endo ◽  
Katsutoshi Yamamoto ◽  
Takeo Naito ◽  
Motoyuki Onodera ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Tumor Necrosis Factor ◽  
Crohn's Disease ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Japanese Patients ◽  
Long Term Prognosis ◽  
Factor Α ◽  
Necrosis Factor

Long-Term Prognosis of Ulcerative Colitis with Onset in Childhood or Adolescence

1979 ◽  
Vol 1 (4) ◽  
pp. 301-306 ◽  
Author(s):  
William M. Michener ◽  
Richard G. Farmer ◽  
E. A. Mortimer
Keyword(s):  
Ulcerative Colitis ◽  
Long Term Prognosis
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