Uterine estrogen sulfatase may play a more important role than the hepatic sulfatase in mediating the uterotropic action of estrone-3-sulfate

Endocrine ◽  
1997 ◽  
Vol 7 (2) ◽  
pp. 191-198 ◽  
Author(s):  
Bao Ting Zhu ◽  
Jia-Huey Fu
Keyword(s):  
Estrogen Sulfatase

In Vivo Inhibition of the Estrogen Sulfatase Enzyme and Growth of DMBA-Induced Mammary Tumors by Melatonin

2010 ◽  
Vol 10 (3) ◽  
pp. 279-286 ◽  
Author(s):  
A. Gonzalez ◽  
V. Alvarez-Garcia ◽  
C. Martinez-Campa ◽  
M.D. Mediavilla ◽  
C. Alonso-Gonzalez ◽  
...  
Keyword(s):  
Mammary Tumors ◽  
Estrogen Sulfatase

Uterine estrogen sulfatase activity. Influence of steroid hormones and adenine nucleotides

1990 ◽  
Vol 36 (4) ◽  
pp. 301-303 ◽  
Author(s):  
MariáCristina Loza ◽  
Antonio Valencia ◽  
Juan José Hicks
Keyword(s):  
Steroid Hormones ◽  
Adenine Nucleotides ◽  
Sulfatase Activity ◽  
Estrogen Sulfatase

scholarly journals Excess estrogen sulfoconjugation as the possible cause for a poor sign of parturition in pregnant cows carrying somatic cell clone fetuses

Reproduction ◽  
2008 ◽  
Vol 136 (5) ◽  
pp. 639-647 ◽  
Author(s):  
Hiroki Hirayama ◽  
Ken Sawai ◽  
Satoru Moriyasu ◽  
Muneyuki Hirayama ◽  
Yuji Goto ◽  
...  
Keyword(s):  
Messenger Rna ◽  
Cell Clone ◽  
Estrone Sulfate ◽  
Hormonal Imbalance ◽  
Estrogen Sulfatase ◽  
Positive Correlations ◽  
And Control ◽  
Estradiol 17Β ◽  
Possible Cause

We conducted this study to elucidate a factor causing a poor sign of parturition and prolonged gestation, which is frequently observed in cows carrying somatic clone fetuses. Pre-partum rises in concentrations of plasma estrone and estradiol-17β in the recipient cows pregnant with clones were subtle. By contrast, the plasma concentration of estrone sulfate in clone pregnancies increased gradually from pre-initiation of parturition induction whereas control cows that receivedin vivo-derived embryos showed a significant increase at parturition. Therefore, in clone pregnancies, the ratio of estrone/estrone sulfate was low during the pre-partum period compared with control. Messenger RNA expression of estrogen sulfotransferase (SULT1E1) in the placenta at parturition was significantly higher in clone pregnancies than control pregnancies and was localized in binucleate cells (BNC).SULT1E1mRNA abundance was negatively and positively correlated with concentrations of maternal estrone and estrone sulfate at parturition respectively. Messenger RNA expressions of estrogen sulfatase (STS) and aromatase (CYP19) were similar between clone and control pregnancies and were localized in BNC and caruncular epithelial cells.STSandCYP19mRNA abundances showed positive correlations with maternal estradiol-17β concentration. The population of BNC in the placenta did not differ between clone and control pregnancies. Plasma cortisol concentration of vaginally delivered newborn clone calves was comparable with those of control, although cesarean section delivered clone calves showed a low concentration. These results suggest that excess estrogen sulfoconjugation is the reason for the perturbed low ratio of active to inactive estrogens and the resulting hormonal imbalance contributes to the lack of overt signs of readiness for parturition in cows pregnant with clones.

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