Studies on the mechanism of malabsorption of cyanocobalamin in blind loop syndrome: with particular reference to the in vitro competition between bacteria and the gastric intrinsic factor

1971 ◽  
Vol 6 (3) ◽  
pp. 183-184
Author(s):  
Takashi Nakajima ◽  
Tsukasa Abe
Keyword(s):  
Intrinsic Factor ◽  
Blind Loop ◽  
Blind Loop Syndrome

Blind Loop Syndrome

Swiss Surgery ◽  
2002 ◽  
Vol 8 (5) ◽  
pp. 220-223 ◽  
Author(s):  
Halkic ◽  
Abdelmoumene ◽  
Kianmanesh ◽  
Vuilleumier
Keyword(s):  
Nous Avons ◽  
Blind Loop ◽  
Blind Loop Syndrome ◽  
Vitamine B12 ◽  
Douleurs Abdominales ◽  
Résection Intestinale

Introduction: Le syndrome de l'anse borgne désigne classiquement les complications des montages chirurgicaux en cul-de-sac de l'intestin grêle (stase entérale, prolifération microbienne, anémie mégaloblastique par malabsorption de la vitamine B12). Le but de ce travail est d'attirer l'attention sur d'autres étiologies, plus rares. Patients et méthode: Ces 20 dernières années, nous avons opéré 9 malades: 5 après anastomose latéro-latérale iléo-iléale et 4 après iléo-transversostomie termino-latérale (2) ou latéro-latérale (2). Leur résection de l'intestin grêle avait été motivée dans 8 cas par l'infarcissement d'une anse grêle sur une bride post-opératoire (appendicectomie 7 fois, opération gynécologique 1 fois) et dans 1 cas par une tumeur. Les manifestations cliniques du syndrome de l'anse borgne ont été: douleurs abdominales en crampes, vomissements, amaigrissement important, diarrhées, asthénie, anémie, altération de l'état général. Le diagnostic a été très tardif, posé en moyenne 18 ans après la résection intestinale. Résultats: Tous les patients ont été traités par antibiothérapie au long cours, résection de leur anastomose latéro-latérale ou termino-latérale et rétablissement termino-terminale de la continuité digestive. Conclusion: Une anastomose iléo-iléale ou iléo-transverse latéro- ou termino-latérale peut créer un cul-de-sac responsable d'une stase fécale avec pullulation bactérienne. Outre une antibiothérapie, le traitement doit rétablir une continuité intestinale termino-terminale.

Percutaneous duodenostomy in blind loop syndrome

1988 ◽  
Vol 150 (5) ◽  
pp. 1199-1199 ◽  
Author(s):  
F Camunez ◽  
G Simo ◽  
A Echenagusia ◽  
P Salom ◽  
A Muro ◽  
...  
Keyword(s):  
Blind Loop ◽  
Blind Loop Syndrome

GASTRECTOMY AND THE BLIND-LOOP SYNDROME

The Lancet ◽  
1960 ◽  
Vol 276 (7162) ◽  
pp. 1205-1209 ◽  
Author(s):  
V.J. Kinsella ◽  
W.B. Hennessy
Keyword(s):  
Blind Loop ◽  
Blind Loop Syndrome

scholarly journals A Case of Blind Loop Syndrome Caused by Infection with Giardia duodenalis Diagnosed with Double Balloon Enteroscopy

2014 ◽  
Vol 8 (3) ◽  
pp. 276-281
Author(s):  
Tomoo Nakagawa ◽  
Tatsuro Katsuno ◽  
Yasushi Mandai ◽  
Masaya Saito ◽  
Sayuri Yoshihama ◽  
...  
Keyword(s):  
Giardia Duodenalis ◽  
Blind Loop ◽  
Blind Loop Syndrome ◽  
Double Balloon Enteroscopy ◽  
Balloon Enteroscopy ◽  
Double Balloon

Cubilin and megalin expression and their interaction in the rat intestine: effect of thyroidectomy

2001 ◽  
Vol 281 (5) ◽  
pp. E900-E907 ◽  
Author(s):  
Raghunatha R. Yammani ◽  
Shakuntla Seetharam ◽  
Bellur Seetharam
Keyword(s):  
Brush Border ◽  
Intrinsic Factor ◽  
Immunoblot Analysis ◽  
Rat Intestine ◽  
Complement Components ◽  
Protein Levels ◽  
Intestinal Brush Border ◽  
Molecular Masses ◽  
Epidermal Growth

Cubilin is a 460-kDa multipurpose, multidomain receptor that contains an NH2-terminal 110-residue segment followed by 8 epidermal growth factor (EGF)-like repeats and a contiguous stretch (representing nearly 88% of its mass) of 27 CUB (initially found in complement components C1r/C1s, Uegf, and bone morphogenic protein-1) domains. Cubilin binds to intrinsic factor (IF)-cobalamin (cbl, vitamin B12) complex and promotes the ileal transport of cbl. The 460-kDa form of cubilin is the predominant form present in the apical brush-border membranes of rat intestine, kidney, and yolk sac, but a 230-kDa form of cubilin is also noted in the intestinal membranes. In thyroidectomized (TDX) rats, levels of intestinal brush-border IF-[57Co]-labeled cbl binding, 460-kDa cubilin protein levels and tissue (kidney) accumulation of cbl were reduced by ∼70%. Immunoblot analysis using cubilin antiserum of intestinal total membranes from TDX rats revealed cubilin fragments with molecular masses of 200 and 300 kDa. Both of these bands, along with the 230-kDa band detected in the total membranes of control rats and unlike the 460-kDa form, failed to react with antiserum to EGF. Mucosal membrane cubilin associated with megalin was reduced from ∼12% in control to ∼4% in TDX rats, and this decreased association was not due to altered megalin levels. Thyroxine treatment of TDX rats resulted in reversal of all of these effects, including an increase to nearly 24% of cubilin associated with megalin. In vitro, megalin binding to cubilin occurred with the NH2-terminal region that contained the EGF-like repeats and CUB domains 1 and 2 but not with a downstream region that contained CUB domains 2–10. These studies indicate that thyroxine deficiency in rats results in decreased uptake and tissue accumulation of cbl caused mainly by destabilization and deficit of cubilin in the intestinal brush border.

scholarly journals A Case of Blind Loop Syndrome at a Functional End-to-end Anastomosis following Laparoscopic Sigmoidectomy

2020 ◽  
Vol 81 (7) ◽  
pp. 1359-1363
Author(s):  
Tomoyuki ONO ◽  
Daisuke NAKANO ◽  
Soichiro NATSUME ◽  
Sakiko NAKAMORI ◽  
Yusuke KITANI ◽  
...  
Keyword(s):  
Blind Loop ◽  
Blind Loop Syndrome ◽  
Laparoscopic Sigmoidectomy ◽  
End To End

The blind loop syndrome after intestinal anastomosis an analysis of 33 cases

1968 ◽  
Vol 3 (2) ◽  
pp. 138-138
Author(s):  
Y. Naritomi ◽  
K. Ohsato ◽  
S. Kitamura ◽  
M. Sakai ◽  
K. Takeda
Keyword(s):  
Intestinal Anastomosis ◽  
Blind Loop ◽  
Blind Loop Syndrome
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