LDL-receptor mRNA expression in liver regeneration after partial hepatectomy

1990 ◽  
Vol 25 (2) ◽  
pp. 274-274 ◽  
Author(s):  
Kyosuke Yamamoto ◽  
Noriko Fukushima ◽  
Iwata Ozaki ◽  
Mitsuaki Motoraura ◽  
Teruyoshi Yanagita ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Mrna Expression ◽  
Partial Hepatectomy ◽  
Ldl Receptor ◽  
Receptor Mrna

Increased LDL receptor mRNA expression in colon cancer is correlated with a rise in plasma cholesterol levels after curative surgery

1995 ◽  
Vol 61 (4) ◽  
pp. 461-464 ◽  
Author(s):  
Axel Niendorf ◽  
Herbert Nägele ◽  
Daisy Gerding ◽  
Udo Meyer-Pannwitt ◽  
Angelika Gebhardt
Keyword(s):  
Colon Cancer ◽  
Mrna Expression ◽  
Plasma Cholesterol ◽  
Ldl Receptor ◽  
Curative Surgery ◽  
Receptor Mrna ◽  
Cholesterol Levels

scholarly journals Inhibitors of AKT kinase increase LDL receptor mRNA expression by two different mechanisms

PLoS ONE ◽  
2019 ◽  
Vol 14 (6) ◽  
pp. e0218537
Author(s):  
Katrine Bjune ◽  
Lene Wierød ◽  
Soheil Naderi
Keyword(s):  
Mrna Expression ◽  
Ldl Receptor ◽  
Akt Kinase ◽  
Receptor Mrna

scholarly journals Liver LDL Receptor mRNA Expression Is Decreased in Human ApoB/CETP Double Transgenic Mice and Is Regulated by Diet as Well as the Cytokine Oncostatin M

1997 ◽  
Vol 17 (11) ◽  
pp. 2948-2954 ◽  
Author(s):  
Jingwen Liu ◽  
Y. Lynda Zhang ◽  
Michael J. Spence ◽  
Robert E. Vestal ◽  
Philip M. Wallace ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Mrna Expression ◽  
Ldl Receptor ◽  
Oncostatin M ◽  
Receptor Mrna ◽  
Double Transgenic Mice

Analysis of LDL Receptor mRNA Expression, Serum Biochemical and Abdominal Fat Weight in Fat and Lean Chickens

2007 ◽  
Vol 7 (4) ◽  
pp. 693-696 ◽  
Author(s):  
H.H. Musa ◽  
J.H. Cheng . ◽  
X.S. Wu . ◽  
H.P. Ju . ◽  
D.M. Mekki . ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Ldl Receptor ◽  
Abdominal Fat ◽  
Receptor Mrna ◽  
Serum Biochemical

scholarly journals Hyperlipidaemic effect of fish oil in Bio F1B hamsters

2004 ◽  
Vol 91 (3) ◽  
pp. 341-349 ◽  
Author(s):  
Pujitha P. de Silva ◽  
Phillip J. Davis ◽  
Sukhinder Kaur Cheema
Keyword(s):  
Fish Oil ◽  
Mrna Expression ◽  
Plasma Lipids ◽  
Control Diet ◽  
Dietary Cholesterol ◽  
Ldl Receptor ◽  
Safflower Seed ◽  
Mrna Levels ◽  
Receptor Mrna ◽  
Fish Oil Diet

We investigated the dietary influence of low and high levels of fish oil, supplemented with or without dietary cholesterol, on the plasma lipoprotein profile in Bio F1B hamsters, a model susceptible to diet-induced hyperlipidaemia. The MIX diet, a diet supplemented with a mixture of lard and safflower-seed oil, was used as the control diet to maintain the saturated MUFA and PUFA levels similar to the fish-oil diet. The animals were fed the specific diets for 2 weeks and fasted for 14h before killing. The plasma from the animals fed high levels of fish oil was milky and rich in chylomicron-like particles. The plasma total cholesterol, VLDL- and LDL-cholesterol and -triacylglycerol concentrations were significantly higher, whereas HDL-cholesterol was lower in hamsters fed fish oil compared with the MIX-diet-fed hamsters. Increasing the amount of fat in the diet increased plasma lipids in both the fish-oil- and the MIX-diet-fed hamsters; however, this hyperlipidaemic effect of dietary fat level was greater in the hamsters fed the fish-oil diet. The hepatic lipid concentrations were not dramatically different between the fish-oil-fed and the MIX-diet-fed hamsters. However, the hepatic LDL-receptor mRNA levels were significantly low in the fish-oil-fed hamsters compared with the MIX-diet-fed hamsters. Increasing the amount of fish oil in the diet further decreased the hepatic LDL-receptor mRNA expression. It is concluded that F1B hamsters are susceptible to fish-oil-induced hyperlipidaemia, especially at high fat levels, and this increase is partially explained by the inhibition of hepatic LDL-receptor mRNA expression.

scholarly journals LDL-Receptor mRNA Expression in Men Is Downregulated within an Hour of an Acute Fat Load and Is Influenced by Genetic Polymorphism

2007 ◽  
Vol 137 (9) ◽  
pp. 2062-2067 ◽  
Author(s):  
Anothai Pocathikorn ◽  
Roger R. Taylor ◽  
Ian James ◽  
Cyril D. S. Mamotte
Keyword(s):  
Genetic Polymorphism ◽  
Mrna Expression ◽  
Ldl Receptor ◽  
Receptor Mrna

Variations in Interferon Gamma Receptor Gene Expression during Liver Regeneration after Partial Hepatectomy in Rats

2009 ◽  
Vol 75 (1) ◽  
pp. 49-54
Author(s):  
Hong-Shiee Lai ◽  
Wen-Hsi Lin ◽  
Wen-Ming Hsu ◽  
Chiung-Nien Chen ◽  
King-Jen Chang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Liver Regeneration ◽  
Mrna Expression ◽  
Partial Hepatectomy ◽  
Interferon Gamma ◽  
Remnant Liver ◽  
Genetic Pathway ◽  
Preoperative Level ◽  
Gamma Receptor ◽  
Ifn Γ

Cell-mediated immunity, which includes interferon gamma (IFN-γ) expression, is activated during the process of liver regeneration; however, the genetic pathway of this activation is still unclear. The present study evaluated variations in the interferon gamma receptor (IFN-γR) gene and its mRNA expression during liver regeneration after partial hepatectomy (PH). Male Wistar rats weighing approximately 200 g were subjected to PH (70 or 40%). IFN-γR gene expression in the remnant liver was measured by cDNA microarray, and mRNA expression was verified by real-time quantitative reverse transcription-polymerase chain reaction (Q-PCR) preoperatively and at 2, 4, 6,12, 24, and 72 hours and 7 days postoperatively. The ratio of remnant liver weight to body weight increased markedly after 70 per cent PH and more gradually after 40 per cent PH. It reached near 90 per cent of the preoperative level at 72 hours after PH in both groups. The scanned spots of the genomic survey on the cDNA microarray chips were uneven and increased irregularly in number and density after PH. IFN-γR gene expression increased markedly in a single peak pattern, up to more than double the preoperative level, at 6 hours after 70 per cent PH. The curve in the 40 per cent PH group was flat and peaked at only 1.6 times the preoperative level. The variations in IFN-γR-related mRNA expression were verified by Q-PCR. Elevations in IFN-γR gene and mRNA expression were shown during the early stage of liver regeneration after PH. The genetic pathway of IFN-γ/IFN-γR expression is activated during liver regeneration.

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