The changes of gastrointestinal mucous membrane effected by anti-cancer agents

Introduction: zinc metabolism disorders, which often accompany the development of a critical state, may lead to numerous heterogeneous metabolic and functional disorders, both in the nervous system and in the other body systems. Objective: to improve intensive care of patients with acute cerebral insufficiency by correcting extracerebral disorders associated with zinc deficiency. Materials and methods: a clinical randomized cohort study included 94 patients aged 18 years with acute cerebral insufficiency. The concentrations of zinc, thiol compounds, intestinal fatty-acid-binding proteins, and interleukin-1β were analyzed. The dynamic changes of these indicators, their relationships with each other, depending on the underlying pathology and the medical correction of zinc sulphate monohydrate and acetylcysteine, were evaluated. Results and discussion: there was a decrease in zinc and thiol compounds serum level in the examined patients that indicates an impairment of transport zinc regulation and antioxidant defence, an increase in the level of intestinal fatty-acid-binding proteins that is a marker of gastrointestinal damage of the mucous membrane of the tract. These changes, as well as the concentration of interleukin-1β, are interrelated and depend on the zinc concentration. The exogenous introduction of zinc sulphate monohydrate and acetylcysteine promotes the normalization of the parameters studied. Conclusions: Patients with acute cerebral insufficiency have extracerebral disorders in the content of thiol compounds, as well as the disorders of the gastrointestinal mucous membrane and pro-inflammatory response. The exogenous introduction of zinc sulphate monohydrate and acetylcysteine contribute to eliminating such disorders.

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THE USE OF GASTROINTESTINAL MUCOUS MEMBRANE AS A REPLACEMENT FOR SKIN–AN EXPERIMENTAL STUDY

Plastic & Reconstructive Surgery ◽

10.1097/00006534-195808000-00005 ◽

1958 ◽

Vol 22 (2) ◽

pp. 139-149 ◽

Cited By ~ 4

Author(s):

CARTER MAGUIRE ◽

NICHOLAS GEORGIADE ◽

JOSEPH McWHIRT ◽

KENNETH PICKRELL

Keyword(s):

Experimental Study ◽

Mucous Membrane ◽

Gastrointestinal Mucous Membrane

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Pathology of Bone Cells in Pigs with Experimental Turbinate Osteoporosis (Atrophic Rhinitis)

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100065560 ◽

1971 ◽

Vol 29 ◽

pp. 304-305

Author(s):

A. W. Fetter ◽

C. C. Capen

Keyword(s):

Mucous Membrane ◽

Bone Cells ◽

Atrophic Rhinitis ◽

Infectious Agents ◽

Metabolic Disturbances ◽

Progressive Reduction ◽

Naturally Occurring ◽

Fundamental Cause ◽

Osteocytic Osteolysis ◽

Uncertain Etiology

Atrophic rhinitis in swine is a disease of uncertain etiology in which infectious agents, hereditary predisposition, and metabolic disturbances have been reported to be of primary etiologic importance. It shares many similarities, both clinically and pathologically, with ozena in man. The disease is characterized by deformity and reduction in volume of the nasal turbinates. The fundamental cause for the localized lesion of bone in the nasal turbinates has not been established. Reduced osteogenesis, increased resorption related to inflammation of the nasal mucous membrane, and excessive resorption due to osteocytic osteolysis stimulated by hyperparathyroidism have been suggested as possible pathogenetic mechanisms.The objectives of this investigation were to evaluate ultrastructurally bone cells in the nasal turbinates of pigs with experimentally induced atrophic rhinitis, and to compare these findings to those in control pigs of the same age and pigs with the naturally occurring disease, in order to define the fundamental lesion responsible for the progressive reduction in volume of the osseous core.

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