A case of chronic gastritis, misdiagnosed as early gastric cancer

1966 ◽  
Vol 1 (3) ◽  
pp. 43-43
Author(s):  
N. Egi ◽  
T. Okuhara ◽  
M. Shibahara ◽  
H. Kodama ◽  
K. Mituta
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Chronic Gastritis

scholarly journals Expression of Oncostatin M in Early Gastric Cancer and Precancerous Lesions

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Jihua Shi ◽  
Xue Xu ◽  
Jun Du ◽  
Haimeng Cui ◽  
Qingfeng Luo
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Chronic Gastritis ◽  
Precancerous Lesions ◽  
Intraepithelial Neoplasia ◽  
Oncostatin M ◽  
Low Grade ◽  
Mucosal Epithelium ◽  
Expression Levels ◽  
Significant Difference

Objective. To detect the expression of the Oncostatin M (OSM) gene and encoded protein in the mucosal epithelium of chronic gastritis, intestinal metaplasia (IM), low-grade intraepithelial neoplasia (LGIN), high-grade intraepithelial neoplasia (HGIN), early gastric cancer (EGC), and advanced gastric cancer (AGC) samples and to explore the correlation and clinicopathological significance of OSM expression in the process of gastric carcinogenesis. Methods. The expression levels of OSM in chronic gastritis, IM, LGIN, HGIN, EGC, and AGC samples were detected by gene chip, real-time quantitative PCR, and immunohistochemical methods. The expression levels of OSM in the gastric mucosa were analyzed, and its correlation with clinical pathology was studied. Results. The expression level of OSM in gastric HGIN and EGC tissues was significantly higher than that in LGIN tissues based on expression profiling (P<0.001). The expression of the OSM gene in EGC was higher than that in HGIN (unpaired t test, P<0.05) and LGIN (unpaired t test, P<0.01) by qPCR. The expression of OSM in LGIN was significantly lower than that in HGIN (P=0.008) and EGC (P=0.044) by immunohistochemical staining. The expression of OSM in HGIN tissues was significantly higher than that in AGC (P=0.007). Conclusion. Alterations in the expression of the OSM gene may be involved in the malignant transformation of the gastric mucosal epithelium. Because of the significant difference in the cancerization rate and clinical management between LGIN and HGIN, the difference in the staining intensity of OSM between LGIN and HGIN may be one of the early markers of gastric intraepithelial neoplasia.

scholarly journals Gastric Xanthoma Associated with Gastric Cancer Development: An Updated Review

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Faycal Awaleh Moumin ◽  
Abdimajid Ahmed Mohamed ◽  
Abdirahman Ahmed Osman ◽  
Jianting Cai
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Chronic Gastritis ◽  
Incidental Finding ◽  
Predictive Marker ◽  
Cancer Development ◽  
Hyperplastic Polyps ◽  
Benign Lesions ◽  
H Pylori ◽  
Foamy Macrophages

Gastric xanthelasma (GX) is a rare tumor-like lesion customarily found as an incidental finding due to its asymptomatic appearance. Grossly, it is a well-marked yellow-white plaque created in the lamina propria by microscopic clusters of foamy macrophages. Xanthelasma is rarely correlated with gastric hyperplastic polyps; gastric xanthomas are rare benign lesions that appear to be associated with inflammation of the gastric mucosa. Etiopathogenesis is also unclear, but it has been suggested to be involved in chronic gastritis, infection with Helicobacter pylori (H. pylori), diabetes mellitus, and hyperlipidemia. The gastric xanthoma prevalence ranges from 0.23% to 7%. Orth first described the condition in 1887. It has been found that xanthelasmas are associated with chronic gastritis, gastrointestinal anastomosis, intestinal metaplasia, and H. pylori infection. These lesions predispose patients to gastric cancer conditions. Xanthoma (GX) was reported to be a predictive marker for early gastric cancer. However, the effectiveness of these scores and xanthoma (GX) as predictive markers for early gastric cancer detected after H. pylori eradication remains unknown.

Effect of Helicobacter pylori infection on early gastric cancer and gastric adenoma

2001 ◽  
Vol 120 (5) ◽  
pp. A658-A658
Author(s):  
E UMEGAKI ◽  
M TANAKA ◽  
N TAKEUCHI ◽  
K NISHIMURA ◽  
M NANRI ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Early Gastric Cancer ◽  
Helicobacter Pylori Infection ◽  
Gastric Adenoma

Comparing single incision gastrectomy with corresponding multiport surgery in early gastric cancer

2018 ◽  
Vol 56 (08) ◽  
pp. e196-e196
Author(s):  
F Berlth ◽  
YS Suh ◽  
SY Oh ◽  
CC Zhu ◽  
SH Park ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Single Incision

Endoscopic submucosal dissection by using Clutch cutter and IT knife 2 for early gastric cancer with severe submucosal fibrosis: a case report

MedPharmRes ◽  
2018 ◽  
Vol 2 (3) ◽  
pp. 17-21
Author(s):  
Nhan Le ◽  
Phuong Vien ◽  
Nghia Le
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Magnifying Endoscopy ◽  
Gastrointestinal Cancers ◽  
Pathological Result ◽  
Well Differentiated ◽  
Submucosal Fibrosis

Introduction: Gastric cancer is one of the highly malignant gastrointestinal cancers and the third leading cause of cancer death. In the last decade, early gastric cancer (EGC) has been reported by using narrow-band imaging (NBI) magnifying endoscopy. Advances in endoscopic techniques, such as endoscopic submucosal dissection (ESD), have enabled the en bloc resection of these EGC. Although ESD is performed for early gastric cancer, there are still many difficult problems in technique of this procedure. The difficulty of gastric ESD depends on the size and location of a tumor, presence of severe submucosal fibrosis, presence of ulceration... We report a case of our successful ESD by using Clutch cutter and IT knife 2 in treatment of EGC with severe submucosal fibrosis. Case presentation: A 62-year-old man felt an epigastric discomfort two months ago. The narrow-band imaging (NBI) magnifying endoscopy revealed a suspected early gastric cancer type 0 - IIa + IIc (Japanese classification of early gastrointestinal cancers) at the incisura angularis, the size of this lesion was 15 mm in diameter, and pathological result of endoscopic biopsy was a well-differentiated adenocarcinoma. ESD was performed and we found there was severe submucosal fibrosis which was dissected safer and faster by using Clutch cutter and IT knife 2. There were no complications such as severe bleeding and perforation. The size of resected specimen was 60 x 35 mm and the time of procedure was 150 minutes. After ESD, the pathological result was a well differentiated adenocarcinoma, pT1a, UL(-), LY(-), V(-), no cancer cell in vertical and horizontal margins. The healing time of ESD-induced ulcer was 5 weeks without local recurrence. Conclusion: Through this case, we aim to emphasize the importance of using Clutch cutter and IT knife 2 as a modified technique which makes ESD a safe procedure in treatment of EGC with severe submucosal fibrosis.

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