Two different types of antimitochondrial antibodies (anti-M2 and anti-M4) may not differentiate primary biliary cirrhosis (PBC) with prominent piecemeal necrosis from classical PBC

1989 ◽  
Vol 24 (1) ◽  
pp. 40-45
Author(s):  
Tadao Okuno ◽  
Michiko Shindo ◽  
Masayuki Matsumoto ◽  
Ken Arai ◽  
Makoto Takeda ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Biliary Cirrhosis ◽  
Antimitochondrial Antibodies ◽  
Different Types ◽  
Piecemeal Necrosis

scholarly journals A sensitive bead assay for antimitochondrial antibodies: Chipping away at AMA-negative primary biliary cirrhosis

Hepatology ◽  
2007 ◽  
Vol 45 (3) ◽  
pp. 659-665 ◽  
Author(s):  
Sabine Oertelt ◽  
Roman Rieger ◽  
Carlo Selmi ◽  
Pietro Invernizzi ◽  
Aftab A. Ansari ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Biliary Cirrhosis ◽  
Antimitochondrial Antibodies

scholarly journals Primary Biliary Cirrhosis Associated with Systemic Sclerosis: Diagnostic and Clinical Challenges

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Cristina Rigamonti ◽  
Dimitrios P. Bogdanos ◽  
Maria G. Mytilinaiou ◽  
Daniel S. Smyk ◽  
Eirini I. Rigopoulou ◽  
...  
Keyword(s):  
Liver Disease ◽  
Systemic Sclerosis ◽  
General Population ◽  
Primary Biliary Cirrhosis ◽  
Early Identification ◽  
Case Reports ◽  
Biliary Cirrhosis ◽  
Antimitochondrial Antibodies ◽  
Favorable Prognosis ◽  
Limited Systemic Sclerosis

Patients with primary biliary cirrhosis (PBC) often have concurrent limited systemic sclerosis (SSc). Conversely, up to one-fourth of SSc patients are positive for PBC-specific antimitochondrial antibodies (AMA). The mechanisms responsible for the co-occurrence of these diseases are largely unknown. Genetic, epigenetic, environmental, and infectious factors appear to be important for the pathogenesis of the disease, but the hierarchy of events are not well defined. Patients with SSc and PBC have an increased morbidity and mortality compared with the general population, but whether the presence of both diseases in an affected individual worsens the prognosis and/or outcome of either disease is not clear. Some case reports suggested that the presence of SSc in PBC patents is associated with a more favorable prognosis of the liver disease, whereas others report an increased mortality in patients with PBC and SSc compared to patients with PBC alone. This paper discusses the features of patients with PBC-associated SSc. Our aims are to clarify some of the pathogenetic, diagnostic, and clinical challenges that are currently faced in the routine management of these patients. We also intend to provide some practical hints for practitioners that will assist in the early identification of patients with PBC-associated SSc.

Detection of novel non-M2-related antimitochondrial antibodies in patients with anti-M2 negative primary biliary cirrhosis

Gut ◽  
2009 ◽  
Vol 58 (7) ◽  
pp. 983-989 ◽  
Author(s):  
M Feuchtinger ◽  
S Christ ◽  
B Preuss ◽  
J Dengjel ◽  
S Duman ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Biliary Cirrhosis ◽  
Antimitochondrial Antibodies

scholarly journals Clinical significance of prominent piecemeal necrosis in primary biliary cirrhosis.

Kanzo ◽  
1987 ◽  
Vol 28 (5) ◽  
pp. 557-563
Author(s):  
Tadao OKUNO ◽  
Masaki IWAI ◽  
Takashi UEDA ◽  
Ongyoku OU ◽  
Toshiaki NAKASHIMA ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Clinical Significance ◽  
Biliary Cirrhosis ◽  
Piecemeal Necrosis

Biochemical markers of liver fibrosis and lymphocytic piecemeal necrosis in UDCA-treated patients with primary biliary cirrhosis

2004 ◽  
Vol 24 (3) ◽  
pp. 187-193 ◽  
Author(s):  
Christophe Corpechot ◽  
Armelle Poujol-Robert ◽  
Dominique Wendum ◽  
Marie Galotte ◽  
Yves Chretien ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Primary Biliary Cirrhosis ◽  
Biochemical Markers ◽  
Biliary Cirrhosis ◽  
Piecemeal Necrosis

Clinicopathological study of primary biliary cirrhosis negative for antimitochondrial antibodies

2008 ◽  
Vol 17 (6) ◽  
pp. 281-287 ◽  
Author(s):  
Yasuni Nakanuma ◽  
Kenichi Harada ◽  
Kyousuke Kaji ◽  
Shuichi Terasaki ◽  
Koichi Tsuneyama ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Biliary Cirrhosis ◽  
Antimitochondrial Antibodies ◽  
Clinicopathological Study
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