Inhibitory effect of etintidine (BL-5641), a new type of H2 receptor antagonist, on binding of [3H]-cimetidine to plasma membrane and histamine-stimulated cellular cAMP production in isolated guinea pig gastric glands

1986 ◽  
Vol 21 (2) ◽  
pp. 106-111
Author(s):  
Shuichiro Nishihara ◽  
Akira Tanaka ◽  
Akihiko Tazoe ◽  
Kouki Yoshida ◽  
Tadashi Misawa ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Guinea Pig ◽  
Receptor Antagonist ◽  
Inhibitory Effect ◽  
Camp Production ◽  
H2 Receptor Antagonist ◽  
Gastric Glands ◽  
H2 Receptor ◽  
New Type

scholarly journals Effects of FRG-8813, a new type histamine H2-receptor antagonist, on various experimental gastric and duodenal lesions in rats.

1992 ◽  
Vol 99 (6) ◽  
pp. 401-410 ◽  
Author(s):  
Tetsuaki YAMAURA ◽  
Masahiro SHIBATA ◽  
Niro INABA ◽  
Sadayoshi ONODERA ◽  
Yuriko CHIDA ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
H2 Receptor Antagonist ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Duodenal Lesions ◽  
New Type ◽  
Histamine H2 Receptor Antagonist

Alteration of histamine response by H2-receptor antagonism in the guinea pig

1980 ◽  
Vol 48 (4) ◽  
pp. 613-618 ◽  
Author(s):  
J. M. Drazen ◽  
C. S. Venugopalan ◽  
M. W. Schneider
Keyword(s):  
Guinea Pig ◽  
Receptor Antagonist ◽  
Fold Increase ◽  
H2 Receptor Antagonist ◽  
Receptor Antagonism ◽  
H2 Receptor ◽  
H2 Receptors ◽  
Histamine Response

Effects of H2-receptor antagonism on the response to histamine was studied in the guinea pig in vivo and in vitro. The H2-receptor antagonist, metiamide (100 micro M), resulted in an enhanced histamine response in eight of eight parenchymal strips and in four of eight tracheal spirals. On the average the parenchymal strips were 20-fold more sensitive to histamine (P less than 0.001), whereas the tracheal spirals demonstrated an insignificant, 20%, increase in sensitivity after metiamide treatment. These results are consistent with the hypothesis that there are inhibitory H2-receptors in guinea pig airways and they predominate in the periphery. When we determined the effects of H2-antagonism on the histamine response in vivo we found that the histamine response was enhanced only in animals that had been treated with the beta-receptor antagonist propranolol. In these animals there was a mean 2.2-fold increase in histamine sensitivity. These results suggest that although there are inhibitory H2-receptors in the guinea pig lung, their role in modulating the in vivo response is much less than beta-adrenergic mechanisms.

Sign in / Sign up

Export Citation Format

Share Document