Effect of intraluminal bile on the feedback regulatory mechanism of pancreatic enzyme secretion in conscious rats

1985 ◽  
Vol 20 (3) ◽  
pp. 234-245 ◽  
Author(s):  
Keisho Kataoka ◽  
Kei Kashima ◽  
Katsuhiko Kinugasa ◽  
Yasuaki Inada ◽  
Yuji Horii ◽  
...  
Keyword(s):  
Regulatory Mechanism ◽  
Pancreatic Enzyme ◽  
Enzyme Secretion ◽  
Conscious Rats ◽  
Pancreatic Enzyme Secretion ◽  
Feedback Regulatory Mechanism

Role of cholecystokinin in the negative feedback control of pancreatic enzyme secretion in conscious rats

1987 ◽  
Vol 92 (2) ◽  
pp. 449-458 ◽  
Author(s):  
Ulrich R. Fölsch ◽  
Per Cantor ◽  
Harald M. Wilms ◽  
Anton Schafmayer ◽  
Horst Dieter Becker ◽  
...  
Keyword(s):  
Feedback Control ◽  
Negative Feedback ◽  
Pancreatic Enzyme ◽  
Enzyme Secretion ◽  
Conscious Rats ◽  
Pancreatic Enzyme Secretion ◽  
Negative Feedback Control

Role of Cholecystokinin in Bombesin-Stimulated Pancreatic Enzyme Secretion in Conscious Rats

Pancreas ◽  
1990 ◽  
Vol 5 (2) ◽  
pp. 194-199 ◽  
Author(s):  
Alphons J. L. de Jong ◽  
Jan B. M. J. Jansen ◽  
Jan C. M. Hafkenscheid ◽  
Cornelis B. H. W. Lamers
Keyword(s):  
Pancreatic Enzyme ◽  
Enzyme Secretion ◽  
Conscious Rats ◽  
Pancreatic Enzyme Secretion

Efficacy of octreotide (Octrade) for prevention of pancreatitis after endoscopic retrograde cholangiopancreatography

2020 ◽  
Vol 1 (30) ◽  
pp. 30-36
Author(s):  
E. A. Krylova ◽  
D. V. Aleinik
Keyword(s):  
Endoscopic Retrograde Cholangiopancreatography ◽  
Intravenous Infusion ◽  
Pancreatic Enzyme ◽  
Enzyme Secretion ◽  
Continuous Intravenous Infusion ◽  
Endoscopic Retrograde ◽  
Pancreatic Enzyme Secretion

The article presents the results of a study of the effectiveness of the use of an inhibitor of pancreatic enzyme secretion of octreotide (Octrade) for the prevention of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP). It was shown that the administration of Octrade at a dose of 0.3 mg in 500 ml of 0.9 % NaCl by continuous intravenous infusion for 7 hours and then 0.1 mg of Octrade subcutaneously at 6 and 12 hours after the end of intravenous infusion significantly reduced the frequency of pancreatitis (4.0 % and 22.2 %; p < 0.05) and hyperamylasemia (8.0 % and 25.9 %; p < 0.05) after ERCP. It is concluded that Octrade is effective in preventing the development of pancreatitis and hyperamilasemia after ERCP.

Pancreatic polypeptide inhibits pancreatic enzyme secretion via a cholinergic pathway

1987 ◽  
Vol 253 (5) ◽  
pp. G706-G710 ◽  
Author(s):  
G. Jung ◽  
D. S. Louie ◽  
C. Owyang
Keyword(s):  
Pancreatic Polypeptide ◽  
Acetylcholine Release ◽  
Pancreatic Enzyme ◽  
Enzyme Secretion ◽  
Dependent Manner ◽  
Amylase Release ◽  
Opioid Receptor Antagonists ◽  
Cholinergic Pathway ◽  
Pancreatic Enzyme Secretion ◽  
Dose Dependent

In rat pancreatic slices, rat pancreatic polypeptide (PP) or C-terminal hexapeptide of PP [PP-(31-36)] inhibited potassium-stimulated amylase release in a dose-dependent manner. The inhibition was unaffected by addition of hexamethonium but blocked by atropine. In contrast, PP(31-36) did not have any effect on acetylcholine- or cholecystokinin octapeptide-stimulated amylase release. In addition, when pancreatic slices were incubated with [3H] choline, PP(31-36) inhibited the potassium-evoked release of synthesized [3H] acetylcholine in a dose-dependent manner. The inhibitory action of PP was unaffected by adrenergic, dopaminergic, or opioid receptor antagonists. Thus PP inhibits pancreatic enzyme secretion via presynaptic modulation of acetylcholine release. This newly identified pathway provides a novel mechanism for hormonal inhibition of pancreatic enzyme secretion via modulation of the classic neurotransmitter function.

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