Changes in serum levels of hepatitis B virus markers after interferon treatment

1989 ◽  
Vol 24 (6) ◽  
pp. 646-654 ◽  
Author(s):  
Hiroshi Ikeda ◽  
Kazuharu Matsuura ◽  
Takao Tsuji
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Serum Levels ◽  
Interferon Treatment ◽  
B Virus ◽  
Hepatitis B Virus Markers

The effect of recombinant α-interferon treatment on serum levels of hepatitis B virus-encoded proteins in man

Hepatology ◽  
1987 ◽  
Vol 7 (4) ◽  
pp. 704-708 ◽  
Author(s):  
Georg Hess ◽  
Wolfram Gerlich ◽  
Guido Gerken ◽  
Michael Manns ◽  
Thomas H. Hütteroth ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Serum Levels ◽  
Interferon Treatment ◽  
B Virus ◽  
Encoded Proteins

Molecular characteristics of hepatitis B virus genotype a confer a higher response rate to interferon treatment

2001 ◽  
Vol 34 ◽  
pp. 15-16 ◽  
Author(s):  
J. Hou ◽  
R. Schilling ◽  
H.L.A. Janssen ◽  
R.A. Heijtink ◽  
R. Williams ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Response Rate ◽  
Molecular Characteristics ◽  
Interferon Treatment ◽  
Virus Genotype ◽  
B Virus ◽  
Genotype A

Assessment of dried blood spot samples as a simple method for detection of hepatitis B virus markers

2011 ◽  
Vol 83 (9) ◽  
pp. 1522-1529 ◽  
Author(s):  
Livia Melo Villar ◽  
Jaqueline Correia de Oliveira ◽  
Helena Medina Cruz ◽  
Clara Fumiko Tachibana Yoshida ◽  
Elisabeth Lampe ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Dried Blood Spot ◽  
Simple Method ◽  
B Virus ◽  
Hepatitis B Virus Markers ◽  
Blood Spot

scholarly journals Genetic polymorphisms of interleukin-6 influence the development of hepatitis B virus-related liver cirrhosis

2019 ◽  
Author(s):  
Caixia Xia ◽  
Wei Zhu ◽  
Chunhong Huang ◽  
Guohua Lou ◽  
Bingjue Ye ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Interleukin 6 ◽  
Serum Levels ◽  
Healthy Controls ◽  
Nucleotide Polymorphisms ◽  
Cross Sectional ◽  
B Virus ◽  
Infected Liver

Abstract Background Interleukin-6 (IL-6) plays an important role in chronic inflammation. Thus, we aimed to investigate the effects of IL-6 polymorphisms in predicting the progression of hepatitis B virus (HBV) -related liver cirrhosis. Methods A cross-sectional study was conducted to analysis IL-6 polymorphisms and serum levels of IL-6 in HBV-infected patients of different clinical phases and in healthy controls. IL-6 polymorphisms were detected by Taqman PCR method and plasma IL-6 levels were assessed by ELISA. Results Our analysis included 182 chronic hepatitis B (CHB) patients, 190 HBV-infected liver cirrhosis cases, 125 inactive HBsAg carriers, and 246 healthy controls. Seven SNPs in IL-6 including rs10499563, rs17147230, rs1800796, rs2069837, rs1524107, rs2066992, rs2069852 were analyzed. In haplotype analysis between HBV-infected liver cirrhosis cases with CHB patients, inactive HBV-carriers or healthy controls, haplotype CT in block 1 and haplotype GGCGG in block 2 were associated with liver cirrhosis (P<0.05). What’s more, the genotype or allele frequencies were significantly different in IL-6 rs10499563 and rs2069837 when HBV-infected liver cirrhosis patients compared with CHB patients, inactive HBV-carriers or healthy controls. A further study found that compared with the controls or CHB patients, plasma IL-6 was elevated in HBV-infected liver cirrhosis patients (P<0.05). Conclusion In conclusion, the polymorphisms of the IL-6 rs10499563 and rs2069837 are associated with the susceptibility of liver cirrhosis may through their effects on IL-6 expressions and these two single nucleotide polymorphisms can be used as potential predicting markers for prognosis of HBV-infected liver cirrhosis.

CHANGING OF HEPATITIS B VIRUS MARKERS IN PATIENTS WITH BONE MARROW TRANSPLANTATION

1990 ◽  
Vol 49 (4) ◽  
pp. 708-713 ◽  
Author(s):  
PO-MIN CHEN ◽  
SHENG FAN ◽  
CHIA-JUI LIU ◽  
RUEY-KUEN HSIEH ◽  
JIN-HWANG LIU ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Marrow Transplantation ◽  
B Virus ◽  
Hepatitis B Virus Markers

Dwindled serum IgG levels of Rubella, Diphtheria toxin, Hepatitis B virus and Tetanus Toxoid after chemotherapy; a report from Iranian children with malignancy

2022 ◽  
Author(s):  
Kazem Ghaffari ◽  
Simin Sarlak ◽  
Abdorrahim Absalan ◽  
Roghayeh Rahimi Afzal ◽  
Aygin Eghbali ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Tetanus Toxoid ◽  
Diphtheria Toxin ◽  
Opportunistic Infections ◽  
Serum Levels ◽  
Serum Igg ◽  
B Virus ◽  
Iranian Children ◽  
Serum Igg Levels

Backgrounds: Epigenetic regulation such as DNA methylation plays a major role in chromatin organization Background: Chemotherapy suppresses immunoglobulin production as a result of cell toxicity. Decreased immunoglobulin levels can result in the onset of opportunistic infections. The aim of the current study is to compare the immunoglobulin G (IgG) levels of the selected vaccine-preventable disease (VPD) before and six months after chemotherapy in a group of Iranian children with malignancies. Materials and Methods: In this interventional study, serum levels of Rubella, Diphtheria toxin, Hepatitis B virus (HBV), Tetanus Toxoid, Mumps, and Measles IgG were measured in 30 children with malignancy and previously vaccinated for these diseases. Six months after chemotherapy, serum IgG levels were reassessed and compared with their corresponding pre-chemotherapy levels. Results: In this study, 17 (56.7%) male and 13 (43.3%) female were included. The mean age was 7.69±3.09 years. After chemotherapy, Rubella IgG levels dropped from 73.88±85.11 to 56.59±72.84 IU/mL (P<0.05; r= 0.956; 33.4% become serum negative (SN)). Diphtheria toxin IgG was diminished from 0.683±0.454 to 0.174±0.248 IU/mL (P<0.05; r=0.601; 26.7% SN). Anti-HBV IgG showed a reduction from 46.26±101.56 to 25.56±80.49 IU/mL (p<0.05; r= 0.524; 60% SN) and Anti-Tetanus Toxoid IgG fell down from 1.031±0.582 to 0.321±0.408 IU/mL (p<0.05; r= 0.365; 33.4% SN). Anti-Measles and Anti-Mumps IgGs showed no significant change (p>0.05). Conclusion: Pediatric chemotherapy was associated with dropped serum IgG levels of most VPDs. A good correlation was also observed between serum levels of IgG before and six months after chemotherapy. Revaccination of children with malignancies may be necessary upon declined serum IgG titers.

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