Studies on serum immunoreactive elastase in experimental pancreatitis rats II. in chronic pancreatitis

1980 ◽  
Vol 15 (6) ◽  
pp. 625-629 ◽  
Author(s):  
Toshinari Kimura ◽  
Kouichiro Imamura ◽  
Masahiro Matsumoto ◽  
Hideyuki Wakasugi ◽  
Hiroshi Ibayashi ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Experimental Pancreatitis ◽  
Immunoreactive Elastase

Enhanced vigilin and anionic trypsinogen expression in experimental chronic pancreatitis

Open Medicine ◽  
2007 ◽  
Vol 2 (2) ◽  
pp. 159-167
Author(s):  
Inken Hilgendorf ◽  
Karen Aßmuth ◽  
Gisela Sparmann ◽  
Jörg Emmrich ◽  
Charli Kruse
Keyword(s):  
Chronic Pancreatitis ◽  
Immunoblot Analysis ◽  
Polyclonal Antiserum ◽  
Experimental Pancreatitis ◽  
Male Rats ◽  
High Affinity ◽  
Pancreatic Cells ◽  
Dibutyltin Dichloride ◽  
Long Time ◽  
Experimental Chronic Pancreatitis

AbstractThe molecular principles that lead to chronic pancreatitis are incompletely understood. Trypsin(ogen) plays a key role in the development of pancreatitis. Since the production of trypsin(ogen) by acinary pancreatic cells is paralleled by the expression of vigilin we hypothesised that vigilin may be involved in the onset of pancreatitis. Vigilin is a ubiquitous protein and has apparently high affinity to RNA.In the present study experimental pancreatitis was induced in male rats by a single intravenous application of dibutyltin dichloride (DBTC). Sections of rat pancreas were immunostained with an affinity-purified polyclonal antiserum against vigilin or trypsin(ogen). The changes in vigilin and trypsin(ogen) protein expression were determined by immunoblotting and subsequent sequence analysis of the amino acids.Induction of pancreatitis by DBTC caused alterations in the distribution and the amount of both vigilin and trypsin(ogen) as shown by immunohistochemical and immunoblot analysis.Furthermore we could demonstrate that anionic trypsinogen expression is up-regulated in DBTC-induced chronic pancreatitis. The obtained results suggest that vigilin as well as trypsin(ogen) are involved in the pathogenesis of pancreatitis and that the long-time DBTC-induced pancreatitis is a useful model for study of chronic pancreatitis.

scholarly journals The Use of Neoprene in Experimental Pancreatitis

2019 ◽  
Vol 70 (2) ◽  
pp. 676-678
Author(s):  
Alexandru Grigorovici ◽  
cristian Velicescu ◽  
Delia Hinganu ◽  
Alina Calin ◽  
Marius Valeriu Hinganu ◽  
...  
Keyword(s):  
Experimental Study ◽  
Acute Pancreatitis ◽  
Chronic Pancreatitis ◽  
Pancreatic Duct ◽  
Genetically Modified ◽  
Pancreatic Tissue ◽  
Experimental Pancreatitis ◽  
Pancreatic Ducts ◽  
Genetically Modified Animals

The concept of chronic pancreatitis has been stated in our country much later than acute pancreatitis. This manuscript proposes a synthesis of the etiopathogenic, diagnostic and therapeutic data in chronic pancreatitis based on actual information correlated with the results of our experimental study. The experiment was conducted on 18 animals, in which was performed the intraduodenal ligation of the pancreatic duct apertures and the obstruction of the pancreatic ducts with intraparenchymatous, intraoperative neoprene injections. We investigated the lesions by using intraoperative pancreatic tissue collected after injections. The results encourage us to continue the research and to choose genetically modified animals because are closer to the human one.

Studies on serum immunoreactive elastase in experimental pancreatitis rats I. in acute pancreatitis

1980 ◽  
Vol 15 (6) ◽  
pp. 620-624 ◽  
Author(s):  
Toshinari Kimura ◽  
Kouichiro Imamura ◽  
Masahiro Matsumoto ◽  
Hideyuki Wakasugi ◽  
Hiroshi Ibayashi
Keyword(s):  
Acute Pancreatitis ◽  
Experimental Pancreatitis ◽  
Immunoreactive Elastase

Deterioration of quality of life in patients with chronic pancreatitis

2001 ◽  
Vol 120 (5) ◽  
pp. A647-A647
Author(s):  
M WEHLER ◽  
R NICHTERLEIN ◽  
B FISCHER ◽  
M FARNBACHER ◽  
U REULBACH ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Pancreatitis

Prevalence of CFTR gene metations in patients with idiopathic chronic pancreatitis

2001 ◽  
Vol 120 (5) ◽  
pp. A646-A646
Author(s):  
F MAIRE ◽  
T BIENVENU ◽  
C AQUAVIVA ◽  
F TRIVIN ◽  
P LEVY
Keyword(s):  
Chronic Pancreatitis ◽  
Cftr Gene ◽  
Idiopathic Chronic Pancreatitis

Senstilization of thoracic sensony neurons in experimental pancreatitis

2001 ◽  
Vol 120 (5) ◽  
pp. A179-A179
Author(s):  
J WINSTON ◽  
M SHENOY ◽  
P PASRICHA
Keyword(s):  
Experimental Pancreatitis
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